Does Lisinopril increase urination? 

Does Lisinopril increase urination?

No, Lisinopril is not associated with increased urination as a side effect. This antihypertensive has no diuretic effect and it generally does not affect your urine output. 

In fact, one of the rare side effects of Lisinopril is decreased urination and it is more common in people who have been using this antihypertensive for a long period of time. 

Long-term users are also susceptible to kidney damage, which can also affect their urine output. Make sure you monitor your side effects and report them to your healthcare provider. 

What side effects are common with Lisinopril?

Lisinopril does not cause frequent urination, but it is associated with some side effects. These include (1,2):

Common side effects

  • Dizziness
  • Headache
  • Cough
  • Fatigue
  • Nausea
  • Upset stomach
  • Bloating 
  • Diarrhoea
  • Rash or skin itching
  • Low blood pressure (hypotension)
  • Changes in taste sensation

Rare side effects (affecting less than 1% of individuals):

  • Angioedema: Swelling of the face, lips, tongue, throat, or extremities, which can be serious and require immediate medical attention (3,4).
  • Hyperkalemia: Elevated levels of potassium in the blood, which can cause abnormal heart rhythms.
  • Renal impairment: Impaired kidney function or worsening of existing kidney problems.
  • Neutropenia: A decrease in white blood cell count, which can increase the risk of infections.
  • Liver dysfunction: chronic liver damage, although it is rare ().
  • Pancreatitis: Inflammation of the pancreas, which can cause severe abdominal pain (5).
  • Hypersensitivity reactions: Allergic reactions characterized by rash, fever, joint pain, or other symptoms.
  • Blood disorders: Rare cases of blood-related disorders, such as thrombocytopenia or anaemia.

As stated earlier, renal impairment caused by Lisinopril may affect urination. In such cases, urinary retention is more commonly reported than frequent urination. 

However, renal impairment with Lisinopril is quite rare and there could be other factors contributing to it, like an underlying kidney disease. Lisinopril may also indirectly cause mood-related side effects in some individuals.

What to do if you are experiencing increased urination?

Talk to your healthcare provider if you are experiencing increased urination without any apparent reason. Your doctor may suggest some tests to diagnose the functioning of your kidneys and bladder and rule out any underlying renal disease. 

Just make sure you do not stop taking Lisinopril without consulting your doctor first. There is a reason why high blood pressure is known as a silent killer and it should be managed properly to prevent more complicated health conditions, especially cardiac illnesses.

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