Does Lisinopril cause mood changes? (3+ side effects that can affect mood)
By
Dr Natalia Marceli Stephanes (PhD)
Author bio
Dr Natália Marcéli Stephanes PhD is a Pharmacist with expertise in Drugs Administration and Toxicity; Discovery of New Drugs; Cancer Treatment; Biochemical Analyzes and Hematological Analyzes. She writes and reviews content on these topics.
Dr Natália Marcéli Stephanes’ Highlights:
- Pharmacist at the Department of Health of Santa Catarina State, Brazil
- PhD with a focus on oncology treatment
- Years of experience in commercial pharmacy
- Bachelor, Master and PhD degrees in Pharmacy at the Federal University of Santa Catarina
Professional Experience:
From her undergraduate studies to her Master’s and Doctorate degrees in Pharmacy, Dr Natália Marcéli Stephanes has participated in numerous scientific studies in the field of oncology and onco-hematology at the University Hospital of the Federal University of Santa Catarina, Brazil. Her research has focused on understanding the molecular and biochemical bases of malignant neoplasms and investigating safer and more effective therapeutic alternatives.
Dr Natália Marcéli Stephanes has also served as an assistant professor of haematology for undergraduate students at the Federal University of Santa Catarina. Additionally, she held the position of professor of Hospital Pharmacy at the Qualificar Technical School in Brazil, where she developed instructional materials for use in the Pharmacy Postgraduate Program at the Leonardo Da Vinci University Center.
In addition to her academic experiences, Dr Natália Marcéli Stephanes possesses a strong expertise in commercial pharmacy, with in-depth knowledge of medications, their routes of administration, desired effects, adverse effects, and toxicity.
Currently, Dr Natália Marcéli Stephanes works as a Pharmacist at the Health Department of Santa Catarina State, where her role entails providing pharmaceutical scientific consulting services to judges.
Education:
- 2016 Bachelor in Pharmacy at the Federal University of Santa Catarina, Brazil
- 2018 Master in Pharmacy at the Federal University of Santa Catarina, Brazil
- 2023 PhD in Pharmacy at the Federal University of Santa Catarina, Brazil
The main publications of Dr Natália Marcéli Stephanes are:
Falchetti M ; Delgobo M, Zancanaro H, Almeida K, Das Neves RN, Dos Santos B, Stefanes NM, et al. Bishop Omics-based identification of an NRF2-related auranofin resistance signature in cancer: Insights into drug repurposing. Comput. Biol. Med [Internet]. 2023; 152:106347.
Feuser PM, Matos dos Santos PC, Cordeiro AP, Stefanes NM, Walter LO, Maioral MF, Santos-Silva MC, et al. Antineoplastic activity of free 4-nitrochalcone and encapsulated in poly(thioether-ester) nanoparticles obtained by thiol-ene polymerization in two human leukemia cell lines (Jurkat and K562). J Drug Deliv Sci Technol [Internet]. 2022; 67:102924.
Jacques AV, Stefanes NM, Walter LO, Perondi DM, Efe FL, Souza LFS, Sens L, et al. Synthesis of chalcones derived from 1-naphthylacetophenone and evaluation of their cytotoxic and apoptotic effects in acute leukemia cell lines. Bioorg. Chem [Internet]. 2021; 116:105315.
Duarte BF, Vieira DSC, Lisboa ML, Stefanes NM, Grando LJ, Santos-Silva MC. Características clínico-epidemiológicas de pacientes portadores de carcinoma de células escamosas de boca. Arquivos Catarinenses de Medicina. 2021; 50(2): 232–245.
Machado V, Jacques AV, Stefanes NM, Santos-Silva MC, Biavatti MW. Anti-leukemic activity of semisynthetic derivatives of Lupeol. Nat. Prod. Res. 2021; 35(22):4494-4501.
Bigolin A, Maioral MF, Stefanes NM, Mascarello A, Chiaradia-Delatorre LD, Nunes RJ, Yunes RA, et al. A novel sulfonamide derivative as a strong and selective apoptotic agent against hematological malignancies. Chem. Pap. 2020; 74:2965–2976.
Bigolin A, Maioral MF, Stefanes NM, Zatelli GA, Philippus AC, Falkenberg MB, Santos-Silva MC. Cytotoxic mechanisms of primin, a natural quinone isolated from Eugenia hiemalis, on hematological cancer cell lines. Anticancer Drugs. 2020; 31(7):709-717.
Maioral MF, Stefanes NM, Neufeldt PD, Chiaradia-Delatorre LD, Nunes RJ, Santos-Silva MC. Aldehyde biphenyl chalcones induce immunogenic apoptotic-like cell death and are promising new safe compounds against a wide range of hematologic cancers. Future Med. Chem. 2020; 12(8):673–688.
Perondi DM, Jacques AV, Stefanes NM, Maioral MF, Sens L, Pacheco LA, Cury NM, et al. A novel thiosemicarbazone as a promising effective and selective compound for acute leukemia. Anticancer Drugs. 2019; 30(8):p 828-837.
Rengifo AFC, Stefanes NM, Toigo J, Mendes C, Argenta DF, Dotto MER, Santos-Silva MC, et al. PEO-chitosan nanofibers containing carboxymethyl-hexanoyl chitosan/dodecyl sulfate nanoparticles loaded with pyrazoline for skin cancer treatment. Eur. Polym. J. 2019; 119:335-343.
Rengifo AFC, Stefanes NM, Toigo J, Mendes C, Santos-Silva MC, Nunes RJ, Parize AL, et al. A new and efficient carboxymethyl-hexanoyl chitosan/dodecyl sulfate nanocarrier for a pyrazoline with antileukemic activity. Mater. Sci. Eng. C [Internet]. 2019; 105:110051.
Maioral MF, Stefanes NM, Bigolin A, Zatelli GA, Philippus AC, Falkenberg MB, Santos-Silva MC. Miconidine acetate, a new selective and cytotoxic compound with synergic potential, induces cell cycle arrest and apoptosis in leukemia cells. Invest. New Drugs. 2019; 37:912–922.
Srefanes NM, Toigo J, Maioral MF, Jacques AV, Chiaradia-Delatorre LD, Perondi DM, Ribeiro AAB, et al. Synthesis of novel pyrazoline derivatives and the evaluation of death mechanisms involved in their antileukemic activity. Bioorg. Med. Chem. 2019; 27(2):375-382.
Maioral MF, Bodack CN, Stefanes NM, Bigolin A, Mascarello A, Chiaradia-Delatorre LD, Yunes RA, et al. Cytotoxic effect of a novel naphthylchalcone against multiple cancer cells focusing on hematologic malignancies. Biochim. 2017; 140:48-57.
You can view some of Dr Natália’s work below and links to her professional profile below.
Research Gate: https://www.researchgate.net/profile/Natalia-Stephanes
Linkedin: https://www.linkedin.com/in/nataliamarceli/
In this article, we will discuss potential mood disturbances caused by Lisinopril, a medication used to manage high blood pressure. We will also discuss some factors that may affect your mood while taking this medication and what one should do if this side effect occurs.
Does Lisinopril cause mood changes?
No, Lisinopril does not generally cause mood changes. It is not known for psychological side effects and is generally tolerated well by its users (1). Some antihypertensive medications are associated with mood changes, but it’s not a commonly reported issue for Lisinopril.
However, it’s important to remember that medications can affect individuals differently, and what one person experiences might not be the same for another.
This is why it is important to talk to your healthcare provider about all the side effects you’re experiencing. Your doctor can help mitigate the side effects to make your treatment more comfortable for you.
What does research suggest?
Research studies have not generally linked Lisinopril with mood changes. One research review discussed a rare case of Lisinopril-induced mania (2,3). The researchers did not find much against the medication and not a single case of mania has been reported after that one case.
Furthermore, some research reviews have discussed the use of Lisinopril as an adjuvant in the treatment of depression (3). This indicates that Lisinopril is not commonly related to mood changes.
Different people have different factors affecting their health, and they may lead to unique or rare side effects in people.
What factors can affect your mood while taking Lisinopril?
There are several factors that may trigger mood changes while taking Lisinopril. These include:
Side effects of Lisinopril
Lisinopril can indirectly affect your mood by causing some side effects. Some of the side effects that can potentially lead to mood disturbances include (1):
- Dizziness – feeling dizzy can be quite unsettling and impact your daily life. It might make it harder to perform tasks or go about your usual activities. This can cause mood changes.
- Headache – persistent headaches can be frustrating and interfere with your regular routine.
- Dry cough – a persistent dry cough can disrupt your sleep and lead to irritation. Sleep disturbances and ongoing discomfort can certainly influence how you feel throughout the day.
Lisinopril can also cause some rare and serious side effects, like abdominal angioedema, that may only appear as bloating at first but could lead to complications as the treatment continues. The drug can also cause kidney damage in some people.
Underlying mood disorders
Some individuals taking Lisinopril might experience mood disturbances, not because of the medication but because of an underlying mood disorder. In such a case, it’s important to consult your doctor to rule out any undiagnosed affective disorder (4).
Individual responses to medication
As discussed earlier, each person’s body chemistry is unique, which means how they respond to medications like Lisinopril can vary. Some individuals might experience mood changes due to their specific physiological makeup.
What to do if you’re experiencing mood changes while taking Lisinopril?
Talk to your healthcare provider if you’re experiencing mood changes while taking Lisinopril. Your doctor will help determine the exact cause of your mood changes and will recommend the best possible solution to help make you feel better.
It is also important to consult a mental health professional if you have a history of mood disorders or if your mood changes are severe. Lisinopril is not generally associated with mood changes and your doctor will discuss other factors with you.
Just make sure you don’t stop taking the medication on your own, especially if you have coronary artery disease, as stopping the medication can put such people at a higher risk of heart attacks.
If your doctor believes that Lisinopril is not the best choice of medication for you, he/she will safely switch you to an alternative medication. Just don’t make any changes to your prescription without consulting your doctor first.
Conclusion
In this article, we have discussed the potential mood changes associated with Lisinopril use. We have also discussed some factors that can trigger mood changes with taking this antihypertensive and what you should do if you experience this side effect.
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References
1.-
Olvera Lopez E, Parmar M, Pendela VS, Terrell JM. Lisinopril. 2023 Jan 17. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 Jan–. PMID: 29489196. Available from: https://www.ncbi.nlm.nih.gov/books/NBK482230
2.-
Skop BP, Masterson BJ. Mania secondary to lisinopril therapy. Psychosomatics. 1995 Sep-Oct;36(5):508-9. doi: 10.1016/S0033-3182(95)71637-1. PMID: 7568661. Available from: https://pubmed.ncbi.nlm.nih.gov/7568661/
3.-
Huffman JC, Stern TA. Neuropsychiatric consequences of cardiovascular medications. Dialogues Clin Neurosci. 2007;9(1):29-45. doi: 10.31887/DCNS.2007.9.1/jchuffman. PMID: 17506224; PMCID: PMC3181843. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3181843/
4.-
Sekhon S, Gupta V. Mood Disorder. 2023 May 8. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 Jan–. PMID: 32644337. Available from: https://www.ncbi.nlm.nih.gov/books/NBK558911
