Does Gabapentin increase blood pressure? 

Does Gabapentin increase blood pressure? 

Gabapentin may or may not increase your blood pressure. Hypertension was reported during clinical trials, but hypotension was more commonly reported with Gabapentin. Experts believe that people respond differently to Gabapentin and this may create variations in side effects. 

Make sure you report your side effects to your doctor. Gabapentin is not an easy medication. In fact, it is considered one of the most dangerous medications in the world. This is why you should not neglect any Gabapentin-induced side effects.

What does research suggest? 

There is no exact explanation as to why Gabapentin affects blood pressure and there is limited research on this topic. However, some experts believe Gabapentin and similar medications, like Pregabalin, may not increase blood pressure as much as they are known to decrease it (1).  

Some studies indicate that Gabapentin can lower blood pressure and heart rate because of its inhibitory effects on your brain. Gabapentin is a gamma-aminobutyric acid (GABA) analogue that mimics the activity of this inhibitor neurotransmitter. 

However, some cases of hypertension are also reported. Researchers believe that the effects of Gabapentin on blood pressure and heart rate could be dose-dependent.

Lower doses are associated with hypertension and increased heart rate, whereas higher or more frequent doses are found to be more closely related to hypotension and decreased heart rate. 

A lot of other factors can also affect you, like your age, your current dose, frequency of dose administration, and any underlying health condition that you may have. 

People who already suffer from hypertension or other cardiac problems are more susceptible to Gabapentin-induced high blood pressure. 

What to do if Gabapentin increases your blood pressure? 

If Gabapentin is increasing your blood pressure, talk to your healthcare provider. Your doctor needs to know about this side effect to determine if you need any dose adjustment or not. 

As I stated earlier, Gabapentin is not an easy medication; it just doesn’t work in some people. If your hypertension persists, your doctor may switch you to another medication. 

However, it is important to ensure you don’t stop using Gabapentin without your doctor’s approval. Meanwhile, here are some tips that you can follow:

  • Limit your salt intake. Excessive salt in your diet can enhance the blood pressure-increasing effects of Gabapentin. 
  • Try to manage your stress levels as stress can also affect your blood pressure. 
  • Cut back on cigarette smoking and alcohol. 
  • Eat healthy foods
  • Exercise at least 3 to 4 times a week. Cardio workouts can help strengthen your cardiac muscles and prevent heart attacks.

Was this helpful?

Thanks for your feedback!



Chen HH, Li YD, Cheng PW, Fang YC, Lai CC, Tseng CJ, Pan JY, Yeh TC. Gabapentin Reduces Blood Pressure and Heart Rate through the Nucleus Tractus Solitarii. Acta Cardiol Sin. 2019 Nov;35(6):627-633. doi: 10.6515/ACS.201911_35(6).20190429B. PMID: 31879515; PMCID: PMC6859102. Available from:


MedlinePlus. Gabapentin [Internet]. Bethesda (MD): National Library of Medicine (US); [updated 2022 Apr 15; cited 2022 Oct 28]. Available from: