Does Effexor Increase Adrenaline? (+Benefits)

This article will discuss the impact of Effexor on adrenaline levels. Furthermore, it will examine the benefits of this impact on noradrenaline levels for treating depression and anxiety.

Additionally, the article will touch upon the potential side effects associated with Effexor’s influence on adrenaline. Finally, it will mention other medications that can affect adrenaline levels or activity.

Does Effexor increase adrenaline?

Effexor can lead to increased availability of adrenaline. Venlafaxine is a serotonin-norepinephrine reuptake inhibitor (SNRI). While it does not directly increase adrenaline levels, it blocks the reuptake of both serotonin and norepinephrine in the brain [1].

Effexor, by inhibiting norepinephrine reuptake, indirectly increases its availability, which is crucial for mood regulation. This may lead to increased sympathetic responses, alertness, and energy levels, potentially aiding in depression treatment.

What are the benefits of Effexor’s impact on adrenaline?

Scientific evidence suggests that increasing adrenaline can help treat depression and anxiety. To illustrate, noradrenaline projections from the locus coeruleus, a part of the brain, are involved in emotional regulation, cognitive functions, motivation, and social relationships. Thus, any deficiency or dysfunction in it can cause depressive symptoms [2].

Postmortem studies reveal differences in the NE system between depressed and healthy individuals. Moreover, studies on mice showed that enhancing the NE system can protect against depression. Conversely, the brain’s depletion of NE after discontinuing certain antidepressants may result in a recurrence of depressive symptoms [3][4].

Antidepressants that increase noradrenaline activity have proven effective in treating depression. SNRIs, such as venlafaxine, have shown better effectiveness in achieving remission compared to SSRIs. This highlights the important role of NE in the pathophysiology and treatment of depression [5].

What are the side effects of Effexor’s impact on adrenaline levels?

It is important to note that an increase in adrenaline and activation of the sympathetic nervous system may lead to certain side effects. It is crucial for individuals taking Effexor, to be aware of and monitor these potential effects under the guidance of a healthcare professional.

These side effects can include [1][6]:

How to manage adrenaline-related side effects of Effexor?

To manage adrenaline-related side effects of Effexor, it is important to work closely with your doctor. However, here are some general management strategies that may be recommended:

  • Regularly monitor your blood pressure and heart rate to instantly detect any abnormalities and ensure early intervention if needed.
  • Adopt a healthy lifestyle, exercise regularly, implement stress management techniques (such as meditation or deep breathing exercises), maintain a balanced diet, get enough sleep, and avoid substances like caffeine, stimulants, or recreational drugs.
  • Dose Adjustment: In some cases, adjusting the dosage of Effexor may help minimize side effects. This should only be done under the supervision of your doctor.
  • Take Effexor in the morning, this may help minimize the impact of noradrenaline’s activity on your sleep patterns.
  • Supportive Medications: in certain instances, your healthcare provider may prescribe additional medications to help alleviate specific side effects. For example, they may recommend antihypertensives or medications that can help you sleep.
  • Report to your doctor and tell them about any concerns or symptoms you may be experiencing. They can provide an appropriate management plan or make necessary adjustments to your treatment plan.

What other antidepressants increase adrenaline?

There are several antidepressant medications that have the potential to increase adrenaline levels, aside from Effexor. Some common options include:

  • Tricyclic antidepressants (TCAs) such as amitriptyline, nortriptyline, and imipramine.
  • Selective serotonin-norepinephrine reuptake inhibitors (SNRIs) like desvenlafaxine, and duloxetine.
  • Norepinephrine-dopamine reuptake inhibitors (NDRIs) such as bupropion.
  • Monoamine oxidase inhibitors (MAOIs) like phenelzine and tranylcypromine.
  • Atypical antidepressants such as maprotiline and vilazodone.

However, the response to these medications can vary among individuals, and the effects on adrenaline levels may not be the same for everyone. It is always recommended to consult with a healthcare professional to determine the most appropriate medication for your condition.


Overall, Effexor can indirectly increase adrenaline levels by inhibiting the reuptake of norepinephrine in the brain. This can lead to enhanced alertness and energy levels, which can be beneficial in treating depression.

Scientific evidence supports the claim that increasing adrenaline through medications like Effexor is effective for treating depression and anxiety.

However, it is important to be aware of potential side effects such as increased heart rate, elevated blood pressure, restlessness, insomnia, weight loss, excessive sweating, headaches, nausea, dizziness, tremors, and anxiety.

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Moret C, Briley M. The importance of norepinephrine in depression. Neuropsychiatr Dis Treat. 2011;7(Suppl 1):9-13. doi: 10.2147/NDT.S19619. Epub 2011 May 31. PMID: 21750623; PMCID: PMC3131098.


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Papakostas GI, Thase ME, Fava M, Nelson JC, Shelton RC. Are antidepressant drugs that combine serotonergic and noradrenergic mechanisms of action more effective than the selective serotonin reuptake inhibitors in treating major depressive disorder? A meta-analysis of studies of newer agents. Biol Psychiatry. 2007 Dec 1;62(11):1217-27. doi: 10.1016/j.biopsych.2007.03.027. Epub 2007 Jun 22. PMID: 17588546.


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