Does Effexor cause irritability? (5+ factors)
By
Ivan Kahwa
Author bio
Mr Ivan Kahwa is a chemist and phytopharmaceutical scientist with expertise in chemistry, pharmacology, phytochemistry, and Nanobiotechnology. He writes and reviews content on these topics.
Mr Ivan Kahwa’s Highlights:
Guest Researcher at the University of Leipzig, Senior Research Fellow/Scientist, and Lecturer at the Department of Pharmacy, Faculty of Medicine, Mbarara University of Science and Technology.
Professional Experience:
Mr Ivan joined PHARMBIOTRAC as a research fellow/scientist during his master of science tenure. He contributed to the development of most of the phytopharmaceutical products in the project. Furthermore, he participated in carrying out the pharmacological activities of the developed products in laboratory animals such as mice and rats in order to develop proper doses hence leading to pre-clinical studies.
With the above relevant research experience, Ivan started to work with the University of Leipzig on collaborative projects with Mbarara University to develop the chemistry of Ugandan Medicinal plants and their pharmacological activities. This was coupled with several consultative positions by different German NGOs. Mr. Kahwa is also a supporting in the teaching and learning at the Departments of Pharmacy and Pharmaceutical Sciences, Faculty of Medicine, Mbarara University of Science and Technology.
With the increase in antimicrobial resistance globally, Ivan retooled his thinking towards developing new naturally derived antibiotic regimens from Ugandan propolis with the assistance of nanotechnology to improve their delivery to microbial cells. Kahwa has also published over 28 articles in peer-reviewed journals and he is currently reviewing for many journals.
Education:
2023-2027: PhD in Pharmaceutical Sciences (ongoing) with a focus on Pharmaceutical Microbiology and Nanobiology at Mbarara University of Science and Technology.
2022: 2Msc. in Pharmacognosy and Natural Medicine Science at Mbarara University of Science and Technology.
2018: Bachelor of Science (Chemistry) at Mbarara University of Science and Technology.
Publications:
▪ Iqbal, S., Jabeen, F., Kahwa, I., & Omara, T. 2023. Suberosin Alleviates Thiazolidinedione-Induced Cardiomyopathy in Diabetic Rats by Inhibiting Ferroptosis via Modulation of ACSL4-LPCAT3 and PI3K-AKT Signaling Pathways. Cardiovascular Toxicology. https://doi.org/10.1007/s12012-023-09804-7
▪ Gupta, A. K., Yadav, R., Sharma, S., Sawale, J., & Kahwa, I. 2023. Anti-ageing Activity and Antioxidant Activity of Methanol Extracts of Leaves and Flowers of Salvia officinalis and Rosmarinus officinalis. Journal of Young Pharmacists, 15(3), 448–455. https://doi.org/10.5530/jyp.2023.15.60
▪ Tolo, C.U., Kahwa, I., Nuwagira, U., Weisheit, A. and Ikiriza, H., 2023. Medicinal plants used in treatment of various diseases in the Rwenzori Region, Western Uganda. Ethnobotany Research and Applications, 25, pp.1-16.
https://ethnobotanyjournal.org/index.php/era/article/view/4683
▪ Kahwa, I., Ajayi, C.O., Yadav, R., Chauhan, N.S., Shah, K., Abdelgadir, A.A., Shegena, E.A., Daniel, S., Omara, T., Asiimwe, J.B. and Ikiriza, H., 2023. Pharmacognostic and phytochemical studies as an invaluable approach for correct identification of medicinal plants: The case of Artemisia vulgaris L. substituted for Artemisia annua L. in Western Uganda. TMR Integr Med, 7, p.e23004.
https://doi.org/10.53388/TMRIM202307004
▪ Nalimu, F., Oloro, J., Kahwa, I. and Ogwang, P.E., 2021. Review on the phytochemistry and toxicological profiles of Aloe vera and Aloe ferox. Future Journal of Pharmaceutical Sciences, 7, pp.1-21.
https://doi.org/10.1186/s43094-021-00296-2
▪ Elamin, O.H.S., Ali, M.A., Elgezuli, I.A.A., Bashir, M.A. and Kahwa, I., 2021. Diagnosis of pre-and post-treatment of echinococcus granulosus with counter current immune electrophoresis and bacterial co-agglutination. Journal of Microbiology and Infectious Diseases, 11(02), pp.88-94.
https://doi.org/10.5799/jmid.951600
Published book Chapter
▪ Kahwa, I., Ayesiga, I., Nakalema, S., Alinaiswe, R., Mbabazi, R. and Iqbal, S., 2023. Natural products in the management of onchocerciasis. In Natural Products in Vector-Borne Disease Management (pp. 63-80). Academic Press. Book Chapter.
https://doi.org/10.1016/B978-0-323-91942-5.00012-4
Submitted manuscripts Under Review:
▪ Comparison of the Wound Healing Activity of the Leaf and Leaf Ash Extracts of Vernonia amygdalina in Rats. Journal name: Clinical Phytoscience
▪ Ethnobotanical Survey of Medicinal plants used in the management of cancer in Uganda. Journal name: Journal of Herbal Medicine
▪ Ethnobotanical survey and phytochemical screening of medicinal plants used in treatment of epilepsy by PROMETRA-Uganda Traditional Health Practitioners in Mpigi District, Uganda. Journal name: Journal of Ethnopharmacology
Submitted book chapters under review
1.Book title: Algae as a Natural Solution for Water-Food-Energy Nexus, Section 4: Microalgae and cyanobacteria for food applications, Chapter 4.6: Safety, toxicological and allergenic aspects of using algae for food. Authors: Christine Kyarimpa, Tom Omute, Caroline K. Nakiguli, Alice V. Khanakwa4, Christopher Angiro, Ivan Kahwa, Fortunate Ahumuza, Timothy Omara*. Publisher: Springer Nature Singapore Pte Ltd. 152 Beach Road, #21-01/04 Gateway East, Singapore 189721, Singapore.
2.Book title: Nutraceuticals Inspiring the Contemporary Therapy for Lifestyle Diseases. Chapter: Nutraceutical applications of Seaweeds and their Phytocompounds in Nutrition and Treatment of Diseases. Authors: Ivan Kahwa, Timothy Omara , Innocent Ayesiga , Gael Noel Neh Neba Ambe , Zehbanaz Javidbhai Panwala , Rachel Mbabazi , Shabnoor Iqbal , Christine Kyarimpa , Christine Betty Nagawa , Kamal Shah ,Nagendra Singh Chauhan* Publisher: CRC Press
You can view my works on the following professional sites:
Research Gate: https://www.researchgate.net/profile/Ivan-Kahwa
Google Scholar: https://scholar.google.com/citations?user=tOwrvqoAAAAJ&hl=en
ORCID: https://orcid.org/0000-0002-6440-3437
Linkedin: https://de.linkedin.com/in/ivan-kahwa-865450159
In this article, we will discuss whether Effexor cause irritability as a side effect or not. We will also discuss the possible connection between Effexor and irritability, what research suggests on this, the potential side effects of Effexor, factors that could contribute to irritability while taking Effexor and what managing strategies we could opt for to minimize or prevent this side effect.
Does Effexor cause irritability?
Yes, Effexor may cause irritability as a common side effect in some people. However, it’s important to remember that people are unique and reacts differently to medications, so it’s not necessary what one person experiences as a side effect, other will experience the same. (3,4)
Effexor is a serotonin-norepinephrine reuptake inhibitor (SNRI). It works by balancing the levels of certain chemicals in the brain called serotonin and norepinephrine, which help improve mood and boost motivation in a person, thereby reducing feelings of depression and anxiety. (2)
If you’re sensing any unusual or concerning side effects while taking Effexor, like irritability, it’s important to reach out to your doctor. They can help you figure out if Effexor is the right choice of treatment for you or not.
What is the connection between Effexor and irritability?
The connection between Effexor (venlafaxine) and irritability lies within the potential side effects of the medication. Some individuals who are taking Effexor can sometimes feel easily annoyed or agitated, which is called irritability. (1)
Not everyone experiences this side effect and for some, Effexor can improve their mood. The reason for this irritability is not entirely clear, but it might be related to how Effexor affects certain chemicals in the brain. Changes in these neurotransmitters can sometimes lead to emotional side effects including, irritability. (2)
If you or someone you know, is experiencing irritability or any other side effects related to Effexor it’s crucial to discuss this with your healthcare provider. They can make adjustments to the treatment plan if necessary and provide you with personalized guidance.
What does research suggest?
Research indicates that irritability is listed as a potential side effect of Effexor (venlafaxine). While it’s an effective medication in the treatment of certain conditions like depression and anxiety, it can make people feel annoyed and agitated. However, not everyone experiences this side effect. (1,4)
The exact mechanism through which Effexor might cause irritability is not entirely clear, but it can be related to its impact on the brain’s neurotransmitters including serotonin and norepinephrine.
If you’re concerned about irritability while taking Effexor, it’s best to have open communication with your healthcare provider.
What to do if Effexor causes irritability?
If you are taking Effexor and it is causing irritability or any other side effect, Here are some steps to consider: (1)
Contact your healthcare provider:
The first and most important step is to consult your healthcare provider. Discuss your symptoms, including the irritability and explain how it’s affecting you.
Adjustments to medication:
Your doctor might suggest adjusting your medication. This could mean changing the dosage, switching to a different medication or adjusting the time of your dosage.
Monitor and patience:
Sometimes, side effects like irritability can subside as your body adjusts to the medication. It may take some time so it’s better for you to be patient and keep an eye on how your body is responding to the medication, if you notice any concerning change that could be bothersome, tell your doctor right away.
Others may include:
Lifestyle modifications, Healthy habits like regular exercise, fixing your sleeping schedule, eating healthy nutrient-rich food and practising stress management techniques like yoga and meditation can complement your treatment.
Medication withdrawal:
If you and your doctor decide to discontinue Effexor due to persistent irritability or other side effects, it’s essential to do so gradually and under medical supervision. Quitting Effexor suddenly may lead to withdrawal symptoms. (4)
What factors could influence irritability while taking Effexor?
Various factors can contribute to irritability while taking Effexor, some of them include: (2,3)
Individual response: Each person’s body and brain chemistry are unique, which means how they respond to a medication like Effexor can differ. Some people may be more prone to feel irritable while some may not.
Dosage: The amount of Effexor you take can impact its side effects like irritability. Higher doses can be more likely to cause side effects.
Treatment duration: The length of time you have been taking Effexor can also influence irritability. Some side effects may appear or change over time as your body adjusts to the medication.
Abrupt changes: Starting or stopping Effexor suddenly without a gradual tapering-off approach, can lead to irritability and other withdrawal symptoms.
Genetic factors: Your genetic makeup can play a role in determining how you respond to and metabolize certain medications including Effexor.
Substance use: Alcohol and other recreational drugs can interact with Effexor and make irritability worse.
What are the other potential side effects of Effexor?
Common side effects of Effexor may include: (3,4)
- Nausea
- Headache
- Insomnia or sleep disturbance
- Dry mouth
- Drowsiness or fatigue
- Lightheadedness or dizziness (changes in blood pressure can lead to dizziness and lightheadedness)
- Excessive sweating including night sweats
- Constipation and diarrhoea
- Nervousness or anxiety
- Weight gain or weight loss
- Sexual side effects, including changes in sexual desire
- Increased blood pressure (higher doses can elevate blood pressure and regular monitoring is required.)
Conclusion:
In this article, we have discussed how Effexor can cause irritability in some individuals as a side effect and how to overcome or prevent the occurrence of these side effects while taking Effexor.
From my perspective, in considering Effexor as a treatment option, it’s crucial to have open and honest communication with your healthcare provider. They can help you with your specific situation by adjusting the treatment plan as needed, to ensure the best therapeutic outcome with fewer side effects.
Was this helpful?
References
1.-
Effexor. MedlinePlus Drug Information. [Internet]. U.S. National Library of Medicine. [Cited 2023 Nov 6]. Available from: https://medlineplus.gov/druginfo/meds/a694020.html
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