Does Cymbalta cause heart palpitations? 5 useful tips

Does Cymbalta cause Heart Palpitations?

Yes, Cymbalta (duloxetine) can cause heart palpitations as a side effect. Although not everyone experiences this, it is important to be aware of all the potential side effects. If concerned about palpitations while taking Cymbalta, consult a healthcare provider for evaluation and guidance.

A study published in February 2013 stated that although safe in other aspects, Cymbalta has prominent side effects on heart activity (1). A 53-year-old patient on Cymbalta was studied under constant supervision and an increase in her heart rate was noted, proving the heart-associated side effects of Cymbalta use.

Are Cymbalta-induced palpitations temporary or permanent?

Cymbalta is a common brand name for the drug duloxetine, which is an antidepressant medication that belongs to the drug class of selective serotonin and norepinephrine reuptake inhibitors (SNRIs). The major side effects associated with duloxetine include nausea, headaches, dry mouth, hair loss, sleep disturbance, and dizziness. Palpitations, which are marked increases in the heart rate, and a feeling of your heart pounding through your chest, are potential side effects of Cymbalta use.

Depending from person to person, the palpitations associated with cymbalta use can be temporary, but also permanent in some cases. Generally, side effects observed with the palpitations occur when the patient first starts using Cymbalta but generally go away as the body gets used to the drug. However, if you encounter any heart palpitations when using Cymbalta, it is important to consult with a healthcare professional for proper evaluation and guidance.

What to do if Cymbalta causes heart palpitations?

Cymbalta can sometimes cause heart palpitations in a patient at the start of the therapy. These heart palpitations usually go away with time, but if these side effects persist, you should follow these steps:

  • Don’t Panic: Stay calm, panicking will only make the situation worse.
  • Contact Your HealthCare professional: Reach out to your doctor or psychiatrist who prescribed the drug. Explain your condition to them and follow their instructions.
  • Seek Emergency help if necessary: If you experience prolonged heart palpitations and the situation is worsening with time, including symptoms like chest pain, dizziness, and shortness of breath, seek immediate medical attention.
  • Take Notes: Keep a record of your medical condition. Note the time and frequency of palpitations along with other associated symptoms.
  • Discuss Alternatives: Your healthcare professional may decide to discontinue the medication and change cymbalta with another drug that can effectively address any underlying condition.

Can Cymbalta-induced Heart Palpitations be life-threatening?

Cymbalta-induced heart palpitations are considered a potential side effect of the medication. These palpitations can be distressing and uncomfortable at times but they are not typically considered life-threatening.

However, every person has a different reaction to any drug being administrated and the responses can vary from person to person. There may be very rare scenarios where the palpitations caused by Cymbalta be considered more severe and have a direct effect on the overall functioning of the heart.

It is however necessary to consult your healthcare professional if you are experiencing any type of changes which you think can have a prominent effect on your health. Your specific situation will be taken into consideration and a specific treatment strategy could be devised by your healthcare professional for your treatment.


Cymbalta (duloxetine) can cause heart palpitations as a potential side effect, although not everyone may experience them. It is crucial to be aware of all potential side effects when taking Cymbalta and consult a healthcare provider if concerned about palpitations. While Cymbalta-induced palpitations are generally not life-threatening, individual reactions may vary, and it is important to seek medical evaluation for any concerning symptoms. Healthcare professionals can assess your specific situation and provide appropriate guidance and treatment strategies,

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Štuhec M. Duloxetine-induced life-threatening long QT syndrome. Wien Klin Wochenschr. 2013;125(3-4):165-166. doi:10.1007/s00508-013-0330-6.



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