Does Cymbalta cause flatulence? (3+ helpful tips)

In this article, we will talk about Cymbalta-induced flatulence. We will also discuss the research findings of Cymbalta-induced side effects. Additionally, we will also discuss the factors contributing to flatulence and some tips to manage Cymbalta-induced flatulence. 

Does Cymbalta cause flatulence? 

Yes, Cymbalta can cause flatulence. Flatulence is a frequently occurring side effect in individuals taking Cymbalta. The side effects experienced with the use of Cymbalta vary among individuals. (1)

Flatulence caused by Cymbalta will subside as the body gets used to the drug. If the side effect persists, consult your physician for proper management. Avoid discontinuing the drug because of the side effects, as it will cause withdrawal symptoms and worsen your condition. 

Cymbalta can also cause other side effects such as drowsiness, dry mouth, dizziness, fatigue, nausea, vomiting, and suicidal ideation and can worsen depression in some individuals. Make sure to consult a doctor if you are experiencing any unwanted side effects. 

What does the research suggest? 

There are no direct research studies which report Cymbalta-induced flatulence. However, flatulence is considered to be a common side effect associated with antidepressants such as Cymbalta. 

Cymbalta can cause other gastrointestinal disorders, such as nausea, dry mouth, diarrhoea, constipation, abdominal pain and vomiting. These side effects were seen commonly in patients being treated with Cymbalta. Infrequent GI side effects associated with Cymbalta were burping, gastritis, halitosis, stomatitis, gastric ulcer, hematochezia and melena. (1)

Duloxetine (Cymbalta) has been shown to reduce flatulence associated with irritable bowel syndrome. A comparison study of fluoxetine and duloxetine’s effects on irritable bowel syndrome (IBD) reported that duloxetine was more effective than fluoxetine in treating flatulence and abdominal pain. (2)

How can Cymbalta cause flatulence? 

Cymbalta is an antidepressant belonging to the group of serotonin-norepinephrine reuptake inhibitors (SNRIs). Cymbalta acts by inhibiting the reuptake of neurotransmitters such as serotonin, norepinephrine and dopamine, which increases the levels of these neurotransmitters in the brain. (3)

Serotonin has an influence on the brain as well as the gastrointestinal tract. About 95% of the serotonin is found in the gastrointestinal tract. Any fluctuations in serotonin levels can cause gastrointestinal symptoms such as flatulence. (4)

Individual sensitivity also plays a role in causing flatulence; individuals who are sensitive to the drug are more susceptible to drug-induced side effects.

What are the factors contributing to Cymbalta-induced flatulence? 

Some factors that may contribute to Cymbalta-induced flatulence include: 

  • Each individual’s body reacts differently to medication. Individuals who are more sensitive to the drug can experience more side effects, such as flatulence. 
  • Diet can contribute to flatulence. Certain foods, such as beans, cabbage, carbonated drinks, etc., can cause flatulence. 
  • Cymbalta can interact with other drugs, such as NSAIDs, stimulants, opioids, etc, which can increase the risk of side effects. 
  • Other drugs, such as aspirin, antacids, Imodium, opioids, iron pills, etc., are also known to cause flatulence. 
  • Gastrointestinal conditions such as irritable bowel syndrome (IBS), inflammatory bowel disease (IBD), celiac disease, Crohn’s disease, etc. are associated with the symptoms of flatulence. 
  • Individuals with lactose intolerance can contribute to flatulence. Emotional factors such as stress and anxiety can influence the digestive system and contribute to flatulence. 

What to do if Cymbalta-induced flatulence does not subside? 

Flatulence caused by Cymbalta usually subsides as the body gets used to the drug. If you have been experiencing prolonged flatulence, which is interfering with your daily activities, consult a physician for proper management. 

Your physician will switch to another antidepressant or reduce the dose of the drug. Any alteration in the antidepressant treatment should be done by a qualified physician. Abrupt discontinuation or fluctuation in the dose can cause withdrawal symptoms and worsen your condition. 

If flatulence persists despite treatment adjustments, it may indicate an underlying disease. Visit your doctor and get a proper evaluation for the cause of the flatulence. 

How to manage Cymbalta-induced flatulence? 

Some of the tips to manage Cymbalta-induced flatulence are as follows: 

  • Identify and limit the food which can cause flatulence, such as beans, onions, or carbonated drinks. Increase fiber intake 
  • Instead of eating large and heavy meals, try eating smaller meals frequently throughout the day. 
  • Drink plenty of water as it can avoid constipation, which can contribute to flatulence. 
  • Use probiotic supplements that contain beneficial bacteria to help manage a healthy balance in the gut microbiome. 
  • Regular exercise can improve digestion and reduce the occurrence of flatulence. 
  • Consider eating food such as ginger or yoghurt, which can reduce gas and bloating. 
  • Avoid caffeine, as it can cause flatulence. 
  • Manage your stress, as stress can contribute to flatulence. You can reduce stress by participating in activities such as meditation, deep breathing, sports, etc. 

In my opinion, Cymbalta can cause flatulence in some individuals. However, this side effect subsides as the body gets used to the drug. Flatulence can also be caused by other factors such as medication, underlying gastrointestinal disease, lifestyle, etc. Hence, it is important to know the cause before treating it. 

If you are experiencing flatulence for a longer period of time, make sure you consult your physician for a proper evaluation. 

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Cymbalta [package insert]. Indianapolis, Eli Lilly and Company. 2004. Available from:  


Jafari S, Sajedi B, Jameshorani M, Salarpour F. Comparison of fluoxetine and duloxetine hydrochloride therapeutic effects on patients with constipation-predominant irritable bowel syndrome. Gastroenterology and Hepatology From bed to Bench. 2022;15(1):45. Available from: 


Dhaliwal JS, Spurling BC, Molla M. Duloxetine. [Updated 2023 May 29]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 Jan-. Available from: 


Terry N, Margolis KG. Serotonergic mechanisms regulating the GI tract: experimental evidence and therapeutic relevance. Gastrointestinal Pharmacology. 2017:319-42. Available from:,%2C%20paracrine%2C%20and%20endocrine%20actions.

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