Does Cymbalta cause vomiting? ( +5 factors)

In this article, we will discuss the vomiting induced by Cymbalta. We will also discuss the research studies exploring the incidence of vomiting associated with Cymbalta and the factors that may influence the likelihood of vomiting as a side effect of Cymbalta. Additionally, we will discuss the management tips for Cymbalta-induced vomiting. 

Does Cymbalta cause vomiting?

Yes, Cymbalta does cause vomiting. Nausea and vomiting are listed as potential side effects of Cymbalta. However, the severity and frequency of vomiting occurring in individuals taking Cymbalta may vary, based on their individual sensitivity to Cymbalta and underlying health conditions. 

Cymbalta is an antidepressant drug. It increases the levels of serotonin as well as norepinephrine in the brain which are responsible for its therapeutic effects. It is used in the management of various conditions such as anxiety, depression, and fibromyalgia (1).

Like other antidepressants, Cymbalta is associated with nausea, vomiting, and gastrointestinal disturbances. Other common side effects of Cymbalta may include, headache, dry mouth, dizziness, drowsiness, sleep disturbances, and weight changes (1). 

What does research suggest?

According to research, nausea and vomiting are frequently reported side effects associated with Cymbalta. A research study findings revealed that nausea occurred in 17% of patients undergoing treatment for depression with Cymbalta over a period of 6 months (2).

A research study reported that the occurrence of Cymbalta-induced nausea and vomiting among patients who received a 60 mg dose was nearly 40%, which is notably higher compared to the 16% observed among the individuals who received a low dosage of Cymbalta 20 mg. These findings underscore the dose-dependent relationship in the manifestation of gastrointestinal side effects associated with Cymbalta (3).

Another study indicated that patients who received Cymbalta preoperatively experienced the development of nausea and vomiting. These findings highlight the need for healthcare providers to be aware of potential gastrointestinal side effects associated with Cymbalta administration, particularly in the perioperative period (4).

What factors can increase the risk of Cymbalta-induced vomiting? 

There are various factors that can increase the risk of nausea and vomiting associated with Cymbalta use. These factors include:

Sensitivity to Cymbalta: People have different reactions to medications, and individual sensitivity plays a significant role. Some individuals are more likely to experience nausea and vomiting with Cymbalta due to their sensitivity to the drug.

Gastrointestinal disorders: Pre-existing gastrointestinal issues, such as irritable bowel syndrome or inflammatory bowel disease, can increase the risk of gastrointestinal side effects including nausea and vomiting when using Cymbalta.

Concurrent use of medications: Combining Cymbalta with other antidepressants can potentiate the side effects of vomiting and nausea, which are commonly associated with antidepressant medications.

Individual factors: Factors such as age can impact how the body reacts to medications. Older adults or individuals with slower metabolism may be at a higher risk of experiencing these side effects.

Cymbalta dosage: A high dosage of Cymbalta is more likely to induce nausea and vomiting. Healthcare providers will typically prescribe the lowest effective dose to minimize side effects.

What to do if Cymbalta causes vomiting?

Vomiting is a common side effect of Cymbalta, but it typically subsides as the patient adjusts to the medication, often without the need for intervention. However, if vomiting is severe or persistent, it is essential to consult healthcare providers promptly to assess the situation and explore appropriate management strategies. 

They may assess your condition and identify the actual cause of your persistent vomiting. If it is related to Cymbalta, they may take the necessary steps to manage it according to your needs.

If Cymbalta is identified as a root cause of vomiting, your healthcare provider may adjust the dosage or prescribe you an alternative to Cymbalta which is less likely to cause vomiting, based on your specific health condition and individual factors. 

However, you should never stop taking Cymbalta suddenly without consulting your healthcare provider. Abruptly stopping the medication can lead to withdrawal symptoms.

Additionally, in some cases, your healthcare provider may prescribe antiemetic medications to help control severe nausea and vomiting induced by Cymbalta. These medications may include:

• Dimenhydrinate
• Promethazine
• Prochlorperazine
• Ondansetron
• Meclizine
• Bismuth subsalicylate

Consider that the selection of an antiemetic relies on factors such as the intensity and severity of nausea, along with individual patient considerations. Prior to using any medication, it is advisable to seek guidance from a healthcare professional and adhere to their recommended usage instructions.

What are alternatives to Cymbalta if it causes vomiting?

Nausea and vomiting are potential side effects of many antidepressant medications. However, the severity and frequency of side effects can vary from person to person as everyone responds differently to medications.

If you are experiencing vomiting as a side effect of your antidepressant, it is crucial to discuss this with your healthcare provider. They can assess your individual situation and may consider alternative medications. Some antidepressants, such as Effexor, Wellbutrin, and Valdoxan, are generally less likely to cause nausea or vomiting compared to others.

While these antidepressants are generally well-tolerated, they may still cause nausea in some individuals. However, they are often considered to be less likely to cause nausea than Cymbalta

In my opinion, and based on my experience as a pharmacist, individuals frequently report vomiting and nausea in clinical settings after taking Cymbalta, although these symptoms often subside with continued use and adjustment periods.

If you are experiencing severe and resistant vomiting, rehydration and the consideration of antiemetic medications under the guidance of healthcare providers are viable strategies for managing these symptoms.

References