Does citalopram cause nerve pain? (+5 factors)

In this article, we will discuss whether citalopram causes nerve pain. We will also discuss the factors that can increase the risk of nerve pain while taking citalopram, and the management of nerve pain if it occurs during citalopram therapy.

Does citalopram cause nerve pain?

No, citalopram does not cause nerve pain. However, some individuals may experience unusual sensations or discomfort while taking citalopram, but it’s essential to consult with a healthcare provider to determine the exact cause and management.

Citalopram is an antidepressant drug that works by inhibiting the reuptake of serotonin, thereby increasing the levels of serotonin in the brain. This medication is commonly prescribed to address a range of mental health conditions, with a particular focus on treating major depressive disorder, anxiety disorders, and obsessive-compulsive disorder (OCD) (1). 

Generally, citalopram is well tolerated with mild to moderate side effects. However, individual responses to medication can vary significantly (1). If you happen to experience never pain, taking the initiative to discuss it with your healthcare provider is a proactive approach to address your worries and investigate potential solutions.

What does research suggest?

There is no research evidence that establishes a direct link between citalopram and the onset of nerve pain. While it may have various other side effects, neuropathic or nerve pain has not been consistently associated with its use in scientific studies.

While some studies have reported a potential association between citalopram and muscle pain or joint pain, there is no evidence suggesting a link to neuropathic pain (1). If you are encountering discomfort in your muscles or joints while using citalopram, it’s vital to consult your healthcare provider. 

While some studies suggest that citalopram may have a role in managing nerve pain, it is essential to clarify that citalopram itself does not cause nerve pain. The use of citalopram for nerve pain should be considered by a healthcare provider based on individual patient needs and circumstances (2).

The incidence of nerve pain while taking citalopram is not well established, but if you do experience any unusual symptoms or side effects while taking citalopram, it’s advisable to consult with your healthcare provider for proper evaluation and guidance.

What factors can contribute to nerve pain while taking citalopram?

Factors that can contribute to nerve pain in individuals taking citalopram can vary and may be unrelated to the medication itself. These factors could include pre-existing medical conditions, nerve-related issues, or even interactions with other medications.

Medical Conditions: Certain underlying medical conditions in individuals who are taking citalopram, such as diabetes, multiple sclerosis, HIV, and cancer, can damage or affect the nerves, leading to neuropathic pain (3).

Medications: Some medications, including certain other antidepressants, anticonvulsants, and anti-cancer drugs, have been associated with nerve pain as a side effect. Concurrent use of these medications while taking citalopram can increase the risk of occurrence of nerve pain (4).

Injury or Trauma: Underlying physical injuries, accidents, or surgical procedures may damage nerves and result in nerve pain, which can be confused as a side effect of citalopram in individuals but it may not be associated with it (5).

Alcohol Abuse: Neuropathic pain can also arise from excessive alcohol consumption. Concomitant use of alcohol with citalopram can increase the risk of nerve pain as well as other potential side effects (6).

Aging: Age can also play an important role in the occurrence of neuropathic pain. Nerve function can deteriorate with age, making older adults more susceptible to nerve pain (7).

What to do if nerve pain occurs while taking citalopram?

If nerve pain occurs while taking citalopram, it’s crucial to promptly report it to a healthcare provider for a comprehensive evaluation. They can determine whether the pain is related to the medication, identify potential causes, and make necessary adjustments to the treatment plan.

Do not stop taking citalopram yourself. Abrupt discontinuation of citalopram may lead to withdrawal symptoms, often referred to as antidepressant discontinuation syndrome. The dose of citalopram should be gradually reduced under the supervision of a healthcare professional when needed.

In some cases, switching to a different antidepressant or addressing any underlying issues may be appropriate. It’s essential to prioritize open communication with a healthcare provider to ensure the most suitable management for any unexpected side effects.

What precautions should be taken while using citalopram?

The following precautions should be considered while using citalopram:

  •  Take citalopram only under the guidance and supervision of a healthcare provider.
  •  Adhere to the specific dosage prescribed by your healthcare provider. Do not alter your dosage without consulting them.
  •  Be aware of the potential side effects of citalopram, and report any unusual side effects to your healthcare provider.
  •  Inform your healthcare provider about all the medications you are taking. This helps avoid potential interactions that could affect the safety and efficacy of citalopram.
  •  Citalopram may interact with alcohol potentially exacerbating side effects. It is advisable to limit or avoid the consumption of alcohol with citalopram.
  •  If you decide to discontinue Celexa, it’s important to do so gradually under the guidance of your healthcare provider.

Conclusion 

In conclusion, there is no established evidence indicating that Ccitalopram causes nerve pain. However, individual responses to medications can vary. It’s my perspective that anyone experiencing unusual symptoms or side effects while taking citalopram, including potential nerve pain, should promptly consult with their healthcare provider.

This proactive approach ensures proper evaluation and personalized guidance based on individual needs and medical history.

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References

1.-

Sharbaf Shoar N, Fariba KA, Padhy RK. Citalopram. [Updated 2021 Dec 11]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK482222/

2.-

Sindrup SH, Bjerre U, Dejgaard A, Brøsen K, Aaes-Jørgensen T, Gram LF. The selective serotonin reuptake inhibitor citalopram relieves the symptoms of diabetic neuropathy. Clin Pharmacol Ther. 1992 Nov;52(5):547-52. doi: 10.1038/clpt.1992.183. PMID: 1424428. https://pubmed.ncbi.nlm.nih.gov/1424428/

3.-

Campbell JN, Meyer RA. Mechanisms of neuropathic pain. Neuron. 2006 Oct 5;52(1):77-92. doi: 10.1016/j.neuron.2006.09.021. PMID: 17015228; PMCID: PMC1810425.https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1810425/

4.-

Jones MR, Urits I, Wolf J, Corrigan D, Colburn L, Peterson E, Williamson A, Viswanath O. Drug-Induced Peripheral Neuropathy: A Narrative Review. Curr Clin Pharmacol. 2020;15(1):38-48. doi: 10.2174/1574884714666190121154813. PMID: 30666914; PMCID: PMC7365998. https://pubmed.ncbi.nlm.nih.gov/30666914/

5.-

Liu XG, Pang RP, Zhou LJ, Wei XH, Zang Y. Neuropathic Pain: Sensory Nerve Injury or Motor Nerve Injury? Adv Exp Med Biol. 2016;904:59-75. doi: 10.1007/978-94-017-7537-3_5. PMID: 26900063. https://pubmed.ncbi.nlm.nih.gov/26900063/

6.-

Chopra K, Tiwari V. Alcoholic neuropathy: possible mechanisms and future treatment possibilities. Br J Clin Pharmacol. 2012 Mar;73(3):348-62. doi: 10.1111/j.1365-2125.2011.04111.x. PMID: 21988193; PMCID: PMC3370340. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3370340/

7.-

Brisset M, Nicolas G. Peripheral neuropathies and aging. Geriatr Psychol Neuropsychiatr Vieil. 2018 Dec 1;16(4):409-413. English. doi: 10.1684/pnv.2018.0768. PMID: 30563801. https://pubmed.ncbi.nlm.nih.gov/30563801/

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