Does citalopram cause erectile dysfunction? (+ 5 factors)

 In this article, we will discuss whether citalopram causes erectile dysfunction (ED). We will also explore research studies linking the use of citalopram to erectile dysfunction. Additionally, we will cover the treatment options for citalopram-induced erectile dysfunction.

Does citalopram cause erectile dysfunction?

Yes, citalopram can cause erectile dysfunction. However, it’s important to note that individual responses to medications can vary, and some people may experience changes in sexual function, including erectile dysfunction, as a side effect of SSRIs (1).

If you are concerned about the possibility of erectile dysfunction or are experiencing any changes in sexual function while taking citalopram or any other medication, it’s crucial to discuss these concerns with your healthcare provider.

They can provide personalized advice based on your specific situation and may consider adjustments to your treatment plan if necessary.

What does research suggest?

According to research, selective serotonin reuptake inhibitors, including citalopram, can have sexual side effects, including erectile dysfunction.

A study reported the occurrence of erectile dysfunction in more than 35% of patients who were taking citalopram for the management of their underlying depression. Additionally, the same study noted other sexual side effects with this medication, such as reduced libido and orgasm (2).

Another study reported that the incidence of sexual side effects of SSRIs, including citalopram, is more than 70% (3). Furthermore, a case was reported where citalopram was used for 2 years at a daily dosage of 20 mg, and side effects, including erectile dysfunction, were noted (6).

What factors can influence citalopram-induced erectile dysfunction?

Several factors may contribute to an increased risk of erectile dysfunction associated with citalopram. These factors may include the following: 

Individual sensitivity Each person’s response to medication is unique. Factors such as genetic variations, individual sensitivity, and overall health can influence how the body reacts to citalopram. Some individuals may be more susceptible to sexual side effects, including erectile dysfunction, due to their individual characteristics.
Concurrent medications  The use of other medications alongside citalopram such as escitalopram, amitriptyline, or Clomipramine can contribute to the increased risk of erectile dysfunction (4). 
Underlying medical conditions Individuals with underlying medical conditions such as cardiovascular diseases, diabetes, or certain neurological disorders may be more prone to experiencing sexual side effects with citalopram (5).
Higher dosage Higher dosages of citalopram may be associated with an elevated risk of experiencing sexual side effects, including erectile dysfunction.  
Duration of treatment Prolonged exposure to citalopram may also increase the likelihood of experiencing sexual side effects, including erectile dysfunction.

What to do if citalopram causes erectile dysfunction?

If you encounter sexual difficulties, specifically erectile dysfunction, while taking citalopram, it is crucial to seek guidance from your healthcare provider. They will evaluate your situation to determine if citalopram is the likely cause of your symptoms.

Your healthcare provider may explore adjustments to your citalopram dosage, especially if higher doses are associated with these side effects. Alternatively, they might consider transitioning you to a different antidepressant that is less likely to cause sexual side effects as compared to citalopram such as Bupropion, Mirtazapine, or Agomelatine.

It is essential not to discontinue citalopram without consulting your healthcare provider, even if you experience side effects such as erectile dysfunction. Attempting to self-medicate to counteract citalopram’s side effects is not advisable. Instead, discuss any concerns or issues with your healthcare provider, who may recommend medications like sildenafil to address sexual side effects.

Patience is key throughout this process, both with the treatment plan and with yourself. Always adhere to the guidance and recommendations provided by your healthcare provider, as they can tailor a treatment plan to your unique needs and work to minimize the impact of any side effects.

Which medications can be used to treat erectile dysfunction?

Several medications are used in the treatment of citalopram-induced erectile dysfunction. Some of the commonly prescribed medications include: 

Phosphodiesterase (PDE5) inhibitors Sildenafil Tadalafil Vardenafil 
Prostaglandin E1 analogs Alprostadil 
Alpha-blockers   Doxazosin Tamsulosin

It is important to note that these medications generally require a prescription, and the choice of which one to use depends on individual preferences, health considerations, the underlying cause of ED, and the advice of healthcare providers.

In my experience

Based on my experience, patients frequently mention experiencing sexual side effects when using citalopram for conditions like depression or anxiety. This occurrence tends to be more prevalent in individuals on prolonged courses or higher doses of the medication.

Seeking professional guidance promptly is crucial when encountering such side effects, allowing for timely intervention and minimizing the risk of potential long-term consequences.

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References

1.-

Sharbaf Shoar N, Fariba KA, Padhy RK. Citalopram. [Updated 2023 Nov 7]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK482222/

2.-

Perlis RH, Laje G, Smoller JW, Fava M, Rush AJ, McMahon FJ. Genetic and clinical predictors of sexual dysfunction in citalopram-treated depressed patients. Neuropsychopharmacology. 2009 Jun;34(7):1819-28. doi: 10.1038/npp.2009.4. Epub 2009 Mar 18. PMID: 19295509; PMCID: PMC9990953. https://pubmed.ncbi.nlm.nih.gov/19295509/

3.-

Hutters CL, Giraldi A. [Sexual side effects from treatment with SSRI]. Ugeskr Laeger. 2022 Apr 4;184(14):V11210824. Danish. PMID: 35410653. https://pubmed.ncbi.nlm.nih.gov/35410653/

4.-

Aldridge SA. Drug-induced sexual dysfunction. Clin Pharm. 1982 Mar-Apr;1(2):141-7. PMID: 6764386. https://pubmed.ncbi.nlm.nih.gov/6764386/

6.-

Csoka AB, Bahrick A, Mehtonen OP. Persistent sexual dysfunction after discontinuation of selective serotonin reuptake inhibitors. J Sex Med. 2008 Jan;5(1):227-33. doi: 10.1111/j.1743-6109.2007.00630.x. Erratum in: J Sex Med. 2008 Dec;5(12):2977.. Csoka, A [corrected to Csoka, AB]. PMID: 18173768. https://pubmed.ncbi.nlm.nih.gov/18173768/

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