Does Citalopram cause aggression? (+5 factors)

In this article, we will discuss citalopram-induced aggression and the other side effects associated with citalopram. We will also discuss the key considerations that should be followed if citalopram causes aggression.

Does Citalopram cause aggression?

Yes, citalopram may cause aggression and agitation. This effect is more common in individuals who are new to citalopram or other SSRIs in general.

Citalopram is a selective serotonin reuptake inhibitor antidepressant medication. It increases the levels of serotonin in the brain, which is responsible for stabilizing and elevating mood and reducing sadness and hopelessness associated with depression, anxiety, and other mood disorders (1).

However, it’s important to note that during the initial phases of therapy, citalopram may impact one’s mood. Individuals may experience fluctuations in their mood and emotional well-being, but as they continue their treatment, citalopram effectively stabilizes their mood (2).

What does research suggest?

According to research, SSRI antidepressants can cause aggression and agitation in the early phase of treatment, on discontinuation of treatment, and during the treatment if the dosage is increased (3). 

Research suggests that citalopram is effective in stabilizing mood in depressive individuals, however, some individuals may experience mood disturbances including aggressive behavior and irritability during the initial stages of therapy (4).

It is important to note that these effects may not occur in everyone and mood disturbances may vary from person to person depending on individual factors.

However, the FDA cautions against aggressive behavior at the start of therapy with Celexa (citalopram) and when adjusting the dosage during therapy. So if you notice any changes in your behavior including aggression, reach out to your healthcare provider (2).

What are the factors that contribute to aggression in citalopram users?

Citalopram-induced aggression can be induced by several factors such as:

Individual factors: People respond differently to medications, some individuals are more susceptible to citalopram-induced aggression.

Early treatment period: Aggression may be more common during the initial phase of treatment, as the body adjusts to the medication.

Drug interactions: Interactions with the other medications you’re taking can also contribute to aggression. Inform your healthcare provider about all the medications you are taking.

Pre-existing conditions: Aggression may be linked to the underlying medical conditions for which citalopram is prescribed. It is important to discuss it with your healthcare provider.  

Dosage: Aggression is more commonly observed in citalopram users when citalopram dosage is changed, either increased or decreased.

What to do if Citalopram causes aggression?

If you experience aggression, agitation, or any mood disturbances after starting citalopram, it’s important to consult your healthcare provider. Your healthcare provider may suggest adjusting citalopram dosage or alternative medications that have fewer mood-related side effects.

Do not make any changes to your prescription or stop taking citalopram by yourself. Abrupt discontinuation of citalopram can lead to withdrawal effects which are even more difficult to manage.

Keep track of your mood and aggression levels over time and report them to your healthcare provider during follow-up appointments. Open communication with your healthcare provider is imperative in finding the best solution for your specific situation.

What are the non-pharmacological approaches for managing citalopram-induced aggression? 

Non-pharmacological approaches for the management of citalopram-induced aggression may include:

Behavioral therapy: Behavioral therapies, such as cognitive-behavioral therapy (CBT) or dialectical Behavior Therapy (DBT) for reducing aggression involve various techniques and interventions aimed at helping individuals manage and decrease their aggressive behaviors. It can help individuals learn to manage their emotions, cope with stress, and address the underlying causes of aggression (6). 

Stress Management: Stress-reduction techniques like mindfulness, meditation, and relaxation exercises can prove valuable in mitigating aggression that may occur during citalopram therapy.

Lifestyle changes: Making changes in one’s daily life, like reducing or eliminating factors that contribute to aggression, such as alcohol or substance use, can be essential.

Conclusion

In conclusion, based on my knowledge citalopram is an effective medication for treating depression, however, its potential to lead to aggressive behavior cannot be dismissed. It is important to note that not everyone will experience this side effect, and the response to citalopram varies from person to person.

In my perspective, an evaluation of the risks and benefits of citalopram is essential before starting this medication. Open communication with a healthcare professional throughout the treatment can help to decrease the risk of aggression and ensure the best possible outcome for those seeking help for depression and anxiety. 

References