Does Cialis (Tadalafil) expire?
By
Dr Drielli Vital-Fujii (PhD)
Author bio
Dr Drielli Vital-Fujii, PhD, is a Pharmacist with expertise in Drug Design and Development, Enzymes, Molecular Modelling, and Photodynamic Therapy. She writes and reviews content on these topics.
Dr Drielli Vital-Fujii’s Highlights:
- Postdoctoral fellow at the Department of Biochemistry at the University of São Paulo, emphasizing therapy of neglected diseases using light.
- PhD in Pharmaceutical Sciences focusing on drug design and development at the Faculty of Pharmaceutical Sciences of the University of São Paulo.
- Six months as an international researcher at the Center for Discovery and Innovation in Parasitic Diseases (University of California San Diego)
- Master’s degree in Pharmaceutical Sciences focusing on drug design and development at the Faculty of Pharmaceutical Sciences of the University of São Paulo.
- Bachelor of Pharmacy at the University of Mogi das Cruzes – São Paulo / Brazil
Professional Experience:
2012 – 2018 Project manager at University of São Paulo – Pharmacy Department
Dr Drielli Vital-Fujii has worked with computational studies, synthesis, biological evaluation, design, and development of new inhibitor candidates for Chagas Disease and Leishmaniasis.
2017 – 2017 International research fellow at University of California San Diego Skaggs School of Pharmacy and Pharmaceutical Sciences – Center for Discovery and Innovation in Parasitic Diseases.
She used Virtual Screening (VS) and High-Throughput Screening (HTS) Integration in the Discovery of new drugs against neglected tropical diseases (NTDs).
2018 – 2019 Faculdades Oswaldo Cruz
Dr Drielli Vital-Fujii was a professor in the Faculty of Pharmacy, teaching the subjects of Pharmaceutical Chemistry and Drug Development.
2019 – 2021 Researcher in Biochemistry University of São Paulo – Biochemistry Department
She applied Photodynamic Therapy in Leishmaniasis Treatment, mentored undergraduate students in scientific activities, and wrote, executed, translated, and reported scientific projects with funding agencies.
2023-2023 UniPiaget – University Center.
Dr Drielli Vital-Fujii was a Biology, Nutrition, Physiotherapy, and Pharmacy professor.
Education:
2018 -2021 Postdoctoral at the Department of Biochemistry at the University of São Paulo
2013 -2018 PhD of Science: Drugs and Medicines at Department of Pharmacy at University of São Paulo
2012 -2013 M.Sc. of Sciences: Drugs and Medicines at the Department of Pharmacy at the University of São Paulo
2005-2008 Bachelor of Pharmacy at the University of Mogi das Cruzes
The leading publications of Dr Drielli Vital-Fujii are:
Vital-Fujii, D.G, Baptista, M.S. (2021). Progress in the photodynamic therapy treatment of Leishmaniasis. Brazilian Journal of Medical and Biological Research, 54, 1-11.
Gatti, F. M., Gomes, R.A., da Fonseca, A.L., Lima, E.J.C., Vital-Fujii, D.G., Taranto, A.G., Varotti, F.P., Trossini, G.H.G. (2020). Antiplasmodial activity of sulfonylhydrazones: in vitro and in silico approaches. Future medicinal chemistry, 13, 233-250.
Silva, E.J., Bezerra-Souza, A., Passero, L.F., Laurenti, M.D., Ferreira, G.M., Fujii, D.G.V., et al. (2018). Synthesis, leishmanicidal activity, structural descriptors and structure-activity relationship of quinoline derivatives. Future medicinal chemistry, 10, 2069-2085.
Leite, F.H.A., Froes, T.Q., da Silva, S.G., de Souza, E.I.M., Vital-Fuji,i D.G., Trossini, G.H.G., et al. (2017). An integrated approach towards the discovery of novel non-nucleoside Leishmania major pteridine reductase 1 inhibitors. European Journal of Medicinal Chemistry, 132, 322-332.
Vital, D.G., Damasceno, F.S., Rapado, L.N., Silber, A.M., Vilella, F.S., Ferreira, R.S., et al. (2017). Application of bioisosterism in design of the semicarbazone derivatives as cruzain inhibitors: a theoretical and experimental study. Journal of Biomolecular Structure and Dynamics, 35, 1244–1259.
Mello, J. F.R., Gomes, R.A., Vital-Fujii, D.G., Ferreira, G.M., Trossini, G.H.G. (2017). Fragment-based drug discovery as alternative strategy to the drug development for neglected diseases. Chemical Biology & Drug Design, 90, 1067-1078.
Pantaleao, S.Q., Fujii, D.G.V., Maltarollo, V.G., da C. Silva, D., Trossini, G.H.G., Weber, K.C., et al. (2017). The Role of QSAR and Virtual Screening Studies in Type 2 Diabetes Drug Discovery. Medicinal Chemistry, 13, 706-720.
Vital, D., Arribas, M., Trossini, G. (2014). Molecular Modeling and Docking Application to Evaluate Cruzain Inhibitory Activity by Chalcones and Hydrazides. Letters in Drug Design and Discovery, 11, 249-255.
Blau, L., Menegon, R.F., Trossini, G.H.G., Molino, J.V.D., Vital, D.G., Cicarelli, R.M.B., et al. (2013). Design, synthesis and biological evaluation of new aryl thiosemicarbazone as antichagasic candidates. European Journal of Medicinal Chemistry, 67, 142-151.
You can view some of Dr Drielli’s work below and links to her professional profile.
Orcid: https://orcid.org/0000-0001-9270-0466
Research Gate: https://www.researchgate.net/profile/Drielli-Gomes-Vital-Fujii
Scopus: https://www.scopus.com/authid/detail.uri?authorId=55829534000
Google Scholar: https://scholar.google.com/citations?user=F9U50AEAAAAJ&hl=pt-BR
Linkedin: linkedin.com/in/driellivital
Escavador: https://www.escavador.com/sobre/6101380/drielli-gomes-vital
CDIPD: https://cdipd.org/index.php/about-us/visiting-scientists
Does Cialis (Tadalafil) expire?
Yes, Cialis (Tadalafil) does expire, like every other medication on this planet. Cialis usually comes with a shelf-life of about 2-3 years. Once the drug is past its labelled expiration date, it’s not recommended to take it.
Now Cialis doesn’t really turn toxic once it expires as research does not show any chemical degradation of this medication. However, it could lose its potency and there’s no way to determine how much potency is left.
This is why The Food and Drug Administration (FDA) recommends staying away from expired meds, just to be safe, as expired meds have no guarantee regarding their safety and efficacy (1).
Potential risks of taking expired Cialis
Taking expired Cialis can pose several potential risks due to the deterioration of the medication over time. As stated earlier, when a medication expires, its chemical composition may change, leading to reduced effectiveness (1).
This means that the expired Cialis may not work as intended in treating erectile dysfunction (2,3). Moreover, expired medications can become less stable, which might result in harmful byproducts that could cause adverse effects on your health.
These effects could range from mild discomfort to more severe reactions. It’s essential to avoid taking expired Cialis and to dispose of any outdated medications properly.
The proper use of Cialis is essential to ensure a safe and effective therapeutic response. It is important not to cut or crush Cialis tablets as it can affect the content uniformity and stability of the drug. However, some alternatives to Cialis, like Viagra, can be cut in half.
How to store Cialis properly to extend its shelf-life?
Properly storing Cialis is essential to extend its shelf-life and maintain its effectiveness. To do this, store the medication in a cool, dry place away from direct sunlight and moisture (4). Avoid exposing it to extreme temperatures, such as freezing or high heat, as these can degrade the medication.
It’s best to keep Cialis in its original container with the lid tightly closed to prevent air and moisture from getting in. Additionally, ensure that you keep Cialis out of reach of children and pets to avoid accidental ingestion (4).
Always check the expiration date before taking the medication and discard any expired or outdated pills responsibly. By following these storage guidelines, you can help ensure that your Cialis remains safe and effective for as long as possible.
How to properly dispose of expired Cialis?
When it comes to disposing of expired Cialis or any other medication, it’s essential to do so safely and responsibly. First, remove the medication from its original container and place it in another bag, preferably with other waste products so you won’t accidentally use it.
You can dispose of it in your household trash bin, making sure to conceal the package to maintain privacy. Avoid flushing expired Cialis down the toilet or throwing it directly in the sink, as it can contaminate water sources.
If you have any concerns or questions about the proper disposal of expired medication, consult your local pharmacy or healthcare provider for further guidance. Remember, safe disposal helps protect the environment and ensures the medication doesn’t end up in the wrong hands.
Was this helpful?
References
1.-
U.S. Food and Drug Administration. Don’t Be Tempted to Use Expired Medicines [Internet]. Silver Spring (MD): U.S. Food and Drug Administration; 2021. Available from: https://www.fda.gov/drugs/special-features/dont-be-tempted-use-expired-medicines.
2.-
Minhas S, Kalsi JS, Ralph DJ. Cialis (tadalafil): a new treatment for erectile dysfunction. Hosp Med. 2003 Oct;64(10):589-92. doi: 10.12968/hosp.2003.64.10.2323. PMID: 14584238. https://pubmed.ncbi.nlm.nih.gov/14584238/
3.-
LABEL: CIALIS- tadalafil tablet, film coated. DailyMed [Internet]. Available from: https://dailymed.nlm.nih.gov/dailymed/getFile.cfm?setid=ebddb745-81f9-4b25-8739-b2886032ed26&type=pdf
4.-
Funk OG, Yung R, Arrighi S, Lee S. Medication Storage Appropriateness in US Households. Inov Pharm. 2021;12(2):1–15. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8326694/pdf/21550417-12-02-3822.pdf
