Does Celexa cause bone loss? (7+ risk groups)

This article will answer the question, “Does Celexa cause bone loss?” We will also discuss potential risk factors and tips to prevent bone loss while taking Celexa.

Does Celexa cause bone loss?

Yes, Celexa (Citalopram) can cause bone loss. Celexa has been associated with an increased risk of bone loss. Celexa is a selective serotonin reuptake inhibitor (SSRI) medication, used for treating depression and anxiety. Celexa can also be used to treat obsessive-compulsive disorder (OCD)

Celexa can disrupt bone formation, causing an imbalance between bone breakdown and build-up. Generally, higher doses of SSRIs, including Citalopram, elevate the risk of bone loss.

What does research suggest?

Research suggests that the use of SSRIs, including Celexa (Citalopram), may harm bone health.

One comprehensive review of 19 studies examining the effects of SSRIs on bone mineral density (BMD) and fracture risk found evidence of a potential association between SSRIs and bone loss-related fractures. This review indicated that SSRIs could weaken bones, increasing the risk of osteoporotic fractures. (1)

Additionally, a systematic review and meta-analysis that analysed 16 studies reported that users of SSRIs were 1.7 times more prone to develop bone fractures than non-users, further suggesting a potential detrimental effect on BMD. (2)

Further research hypothesises that chronic use of SSRIs may reduce bone formation, resulting in an imbalance between bone breakdown and build-up, ultimately contributing to bone loss. (3)

Studies have consistently reported bone loss and reduced BMD associated with these antidepressant medications, emphasising the importance of considering potential bone health risks when using SSRIs. (4)

Another study indicated a higher risk of bone loss in postmenopausal women because of osteoporosis and decreased bone density. (5)

It is essential to be aware of these findings and discuss any concerns with your healthcare provider, particularly if you are taking or considering Celexa or other SSRIs.

What factors increase the risk of bone loss while taking Celexa?

Several factors can increase the risk of bone loss and osteoporosis while taking Citalopram (Celexa) or other selective serotonin reuptake inhibitors (SSRIs): (4,5)

  • Age: Osteoporosis risk tends to rise with age, making older individuals more susceptible.
  • Ethnicity: White and Asian people are at a higher risk of developing osteoporosis.
  • Family History: If you have a family member, especially a parent or sibling, with osteoporosis, especially if they’ve experienced a hip fracture, your risk increases.
  • Body Frame Size: People with smaller body frames are at a higher risk because they may have less bone mass.
  • Medical Conditions: Certain health conditions like celiac disease, IBS, liver or kidney disease, cancer and arthritis can elevate the risk of osteoporosis.
  • Lifestyle Choices: Sedentary living, smoking, excessive alcohol consumption, and inadequate nutrition, particularly low calcium or vitamin D intake, can contribute to the risk of osteoporosis.
  • Menopausal Women: Women who use SSRIs like Celexa to manage menopausal symptoms are also at a heightened risk of bone loss.

What to do if Citalopram is affecting your bones?

If you are taking Celexa and are concerned about its potential impact on your bones, here are some steps you can take:

Talk to your healthcare provider

Open communication with your healthcare provider is crucial. Discuss your concerns about the effects of the medication on your bones. They can assess your risk factors and provide guidance accordingly.

Consider getting a bone density test, also known as a DXA scan. This test measures your bone mineral density. This evaluation is important to know if you have osteoporosis or are at risk of developing it.

Lifestyle changes

Implementing a healthy lifestyle is paramount in supporting and preserving bone health. Regular exercise can help maintain bone density and health. A balanced diet rich in calcium and minerals is also important. Include lean protein and dairy products in your diet to keep yourself fit.

Caffeine should be limited when taking Celexa or any other SSRI such as Sertraline. In addition, smoking cessation and limiting alcohol also reduce the risk of bone loss. 

Medication considerations

Depending on your risk factors and bone health status, your healthcare provider may recommend specific medications, such as supplements, to prevent or treat osteoporosis.

Maintaining your mental health treatment is essential. Abruptly discontinuing antidepressant medication can have adverse effects on your mental well-being. Follow the advice of your doctor completely.


In conclusion, the relationship between Citalopram (Celexa) and its potential impact on bone health is a matter of growing concern.

Research suggests that the use of selective serotonin reuptake inhibitors (SSRIs), including Celexa, may be associated with an increased risk of bone loss and fractures.

While the precise mechanisms behind this link are not fully understood, it is evident that individual factors such as age, gender, family history, and lifestyle choices can further influence this risk.

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