Does Celexa cause apathy? (+5 factors)

In this article, we will discuss whether Celexa causes apathy. We will also explore research studies linking the use of Celexa to the occurrence of apathy. Additionally, we will delve into factors that may increase the risk of apathy while using Celexa, as well as management tips for Celexa-induced apathy.

Does Celexa cause apathy?

Celexa may cause apathy. However, this is not a frequently reported side effect of this medication. Symptoms like apathy, increased anxiety, or depression are sometimes common during the initial phase of treatment with citalopram or SSRIs in general. However, these side effects usually subside as the body adjusts to the medication.

Celexa is a brand name for citalopram, which is an antidepressant medication. It is frequently employed in the management of depression, anxiety, and obsessive-compulsive disorder (1).

While it is generally considered a safe and well-tolerated medication, it may cause some side effects that are more frequent during the initial period of treatment, such as nausea, vomiting, dizziness, appetite changes, and weight gain (1).

What does research suggest?

Based on research findings, the occurrence of apathy is prevalent among individuals using antidepressant medications, including citalopram.

A specific research study highlighted that selective serotonin reuptake inhibitors, such as citalopram, are linked to a substantial risk of inducing apathy in patients undergoing treatment for their underlying depression, with an incidence rate exceeding 50% (2).

Furthermore, reports from the Food and Drug Administration emphasize that apathy is a common side effect associated with the use of citalopram, particularly during the initial stages of treatment (3).

What factors may increase the risk of Celexa-induced apathy?

Various factors can contribute to an increased risk of Celexa (citalopram) inducing apathy:

The initial phase of treatment  Apathy and other side effects may be more prominent during the initial phase of treatment as the body adapts to the medication.
Dosage and Treatment Duration   Increased dosage or prolonged use of Celexa may elevate the risk of side effects, including apathy. Abrupt changes in dosage could also play a role. 
Individual variability  People exhibit diverse responses to medications, and susceptibility to apathy as a side effect of Celexa can vary. 
Underlying medical conditions  The presence of pre-existing conditions or concurrent mental health disorders, particularly depression, may heighten the likelihood of apathy. A comprehensive understanding of the patient’s overall health and mental health history is crucial. 
Concurrent medications  Simultaneous use of other medications, such as additional antidepressants or lithium, may interact with Celexa, amplifying the risk of adverse effects, including apathy.

What to do if Celexa causes apathy?

If Celexa causes apathy, it is important to address the situation promptly. While these side effects are often common during the initial phase of treatment and tend to subside as the body adjusts, persistent apathy requires attention.

In such cases, it is recommended to consult with healthcare professionals. They will conduct an assessment to determine the cause and suggest appropriate actions. Depending on their evaluation, adjustments to the Celexa dosage or discontinuation may be considered, with careful consideration of the associated risks and benefits.

Healthcare providers may also explore alternative antidepressants that are less likely to cause apathy such as bupropion. It’s crucial to emphasize that you should not discontinue Celexa without the guidance of your healthcare provider, as abrupt discontinuation may lead to withdrawal effects that might worsen your symptoms.

What are the management tips for Celexa-induced apathy? 

Managing apathy associated with Celexa or any antidepressant requires a comprehensive approach and close collaboration with healthcare professionals. Here are some management tips for managing symptoms of apathy:

  • Assess lifestyle factors such as sleep, diet, and exercise, as they can impact mental health and overall well-being.
  • Consider incorporating psychotherapy into your treatment plan to address and manage symptoms.
  • Incorporate mindfulness techniques or meditation to manage stress and enhance overall well-being.
  • Consider dietary changes or supplements that may support mental health, under the guidance of a healthcare professional.
  • Prioritize good sleep hygiene to ensure sufficient and restful sleep.
  • Minimize alcohol use as it can impact mental health and exacerbate symptoms.
  • Consider cognitive-behavioral techniques to address negative thought patterns. 
  • Practice mindful breathing exercises to manage stress and promote relaxation.
  • Explore alternative therapies such as acupuncture or massage under professional guidance.

In my experience

In my experience, individuals who have recently started taking Celexa often report symptoms like apathy and increased depression in clinical settings. In such instances, healthcare providers commonly counsel patients to exercise patience, as these symptoms usually alleviate within 2 to 3 weeks of initiating treatment.

However, if the symptoms exacerbate or persist, especially considering underlying factors, healthcare providers typically intervene by offering personalized interventions. 

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References

1.-

Sharbaf Shoar N, Fariba KA, Padhy RK. Citalopram. [Updated 2023 Nov 7]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK482222/ 

2.-

Masdrakis VG, Markianos M, Baldwin DS. Apathy associated with antidepressant drugs: a systematic review. Acta Neuropsychiatr. 2023 Aug;35(4):189-204. doi: 10.1017/neu.2023.6. Epub 2023 Jan 16. PMID: 36644883. https://pubmed.ncbi.nlm.nih.gov/36644883/

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