Does Celexa affect dopamine levels? (+5 side effects)

In this article, we will discuss whether Celexa (Citalopram) affects dopamine levels in the body, understanding dopamine and its role in the brain, and the research studies investigating the effects of Celexa on dopamine.

Does Celexa affect dopamine levels?

Celexa may affect the dopamine levels in the brain. Celexa (Citalopram) may suppress the level of dopamine in some individuals but this is not its primary mechanism of action.

Celexa (citalopram) belongs to an SSRI antidepressant class. It primarily works on the elevation of serotonin levels in the brain by inhibiting its reuptake. It is indicated in the treatment and management of major depressive disorders, anxiety, and obsessive-compulsive disorder (1).

On the other hand, dopamine is a neurotransmitter found in the central nervous system. It plays an important role in regulating physiological processes by binding to G protein-coupled receptors. Maintaining the balance of dopaminergic signaling pathways is essential for overall health, as disruptions can contribute to neurodegenerative diseases and related dysfunctions (5).

What does research suggest?

There is currently limited research focusing on the effects of Citalopram on dopamine levels in the brain. While much is known about the medication’s impact on serotonin, its specific interactions with dopamine remain an area of ongoing investigation (1).

According to a study, Celexa has the potential to lower dopamine levels in the prefrontal cortex of the brain (2). This is significant because excess dopamine in the brain can contribute to the elevation of stress responses, agitation, and sleep disturbances (3).

Another study suggested that SSRIs may inhibit the neuroendocrine dopamine release through both serotonin-dependent and independent actions. The reduction in hypothalamic dopamine neurons elevates the level of prolactin in the body leading to the sexual side effects of SSRIs (4).

The interaction between serotonin (5-HT) and dopamine (DA) in the brain involves various receptor subtypes. The prevailing influence appears to be inhibitory, with a more pronounced effect in the mesocorticolimbic DA system compared to the DA nigrostriatal system (6).

How does Celexa affect dopamine levels?

Celexa increases the levels of serotonin in the brain, which in turn reduces dopamine levels because serotonin and dopamine are interconnected and changes in one can affect the other. When one neurotransmitter is altered, it impacts the function and concentration of the other. This interplay influences various aspects of behavior.

However, these interactions are not fully understood and may vary from person to person. It’s essential to discuss any specific concerns about how Celexa might affect dopamine levels with a healthcare professional. 

What is the role of dopamine in the brain? 

Dopamine plays a crucial role in the brain, particularly in specific regions responsible for various integrated functions that support automatic and highly adaptive behaviors.

In the course of brain development, dopamine exhibits trophic properties, directly influencing cortical specification, with a notable impact on prefrontal regions. This role is evident in the strong connections between the maturation of dopamine cortical innervation and the development of cognitive abilities (5).

Dopamine plays a vital role in central neurotransmission, exerting various effects within the mesocorticolimbic reward pathway. Traditionally, dopamine’s role in reward processing was linked to the capacity to experience pleasure, but recent findings indicate a more motivational function (7). 

What side effects of Celexa are associated with low dopamine levels?

The low dopamine level associated with the use of Celexa may sometimes lead to potential side effects such as: (8)

• anhedonia
• apathy
• dysphoria
• decreased motivation
• emotional blunting

Alterations in dopamine transmission can lead to feelings of unease or dissatisfaction. However, it is important to note that these side effects can vary among individuals, and not everyone may experience them.

What to do if Celexa is affecting your dopamine levels?

If you suspect that Celexa is reducing your dopamine levels or if you’re experiencing side effects related to dopamine regulation, the first and most important step is to reach out to your healthcare provider or psychiatrist. Discuss your concerns and any specific symptoms you’re experiencing.

Your healthcare provider may review your current medication regimen and consider alternative antidepressants or adjustments to your Celexa dosage. They can help you make an informed decision about the best treatment for your condition.

Keep track of your symptoms and side effects while working with your healthcare provider. Regularly reporting changes or improvements in how you feel can guide treatment adjustments.

Adhere to the treatment plan recommended by your healthcare provider. If any changes are made to your medication or treatment, make sure to follow their guidance closely.

Conclusion  

In conclusion, Celexa may affect levels of dopamine in the brain by increasing serotonin levels.  The potential impact of Celexa on reducing dopamine levels has implications for various aspects of behavior and physiology, such as mood regulation. 

It is clear that more research is needed to fully understand the extent and specific effects of this interaction in the examination and treatment of conditions associated with imbalances in neurotransmitters.

References