What is the difference between Lamisil and Lotrimin?

What is the difference between Lamisil and Lotrimin?

Lamisil and Lotrimin differ in a number of ways. Let’s take a look at them (1,2):

Traits Lamisil Lotrimin
Nature Antifungal Antifungal 
Active pharmaceutical ingredientTerbinafine Clotrimazole (most common)Butenafine Miconazole Tolnaftate
Route of administrationTopical Topical 
Mechanism of actionFungicidal – kills the infection-causing fungiFungistatic – inhibits the growth of infection-causing fungi
Treatment duration1-3 weeks, depending on the severity  2-5 weeks, depending on the severity  

Both of these topical antifungal preparations are available over-the-counter and they are used in the treatment and management of skin diseases like Athlete’s foot, ringworm, and Jock itch. 

They are available in various forms, including creams, sprays, powders, and gels. It is important to use these medications consistently and complete the full course of treatment, even if symptoms improve before completing the prescribed duration (1,2).

Always follow the instructions provided by your healthcare provider or the product label. If you have any concerns or questions about using Lamisil or Lotrimin, consult a healthcare professional.

It is important to seek medical attention if your condition worsens or does not improve after using the medication or if you experience any signs of an allergic reaction, such as rash, itching, swelling, etc.

How to choose between Lamisil and Lotrimin?

When choosing between Lamisil and Lotrimin for treating fungal skin infections, the following factors are considered (1,2):

  • Type of infection: Determine the specific type of fungal infection you have. Lamisil is effective against certain types of fungal infections, while Lotrimin is more suitable for others. Your healthcare provider can help identify the type of infection and recommend the appropriate treatment. For example, Lamisil is considered the drug of choice for toenail fungus.
  • Symptoms and severity: Assess the severity of your symptoms. If your infection is mild and localized, Lotrimin may be sufficient. However, for more persistent or severe infections, Lamisil might be a better option due to its broader antifungal properties.
  • Product form: Both Lamisil and Lotrimin come in various forms, such as creams, sprays, and powders. Choose the product form that is most convenient for you to apply to the affected area.
  • Personal preference: Some people may have a personal preference for one product over the other based on past experiences or recommendations from healthcare professionals or friends.
  • Medical history: Inform your healthcare provider about any existing medical conditions or allergies you have to ensure that the chosen antifungal medication is safe for you to use. Lamisil can damage the liver and such medications are not recommended for people with pre-existing liver diseases.
  • Drug interactions: If you are taking other medications, discuss potential drug interactions with your healthcare provider to avoid any adverse effects.

Final words

To sum up, Lamisil and Lotrimin differ from one another in some ways, although they both are topical anti-fungal medications. However, they both can be used for the relief of similar symptoms. 

Make sure you talk to your doctor or pharmacist if you are confused about using the right type of antifungal medication.

Was this helpful?

Thanks for your feedback!



Maxfield L, Preuss CV, Bermudez R. Terbinafine. 2023 May 29. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 Jan–. PMID: 31424802. https://www.ncbi.nlm.nih.gov/books/NBK545218


Khatter NJ, Khan MAB. Clotrimazole. 2022 Jul 11. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 Jan–. PMID: 32809478. https://www.ncbi.nlm.nih.gov/books/NBK560643