What is the best time of day to take Meloxicam?
By
Dr Natalia Marceli Stephanes (PhD)
Author bio
Dr Natália Marcéli Stephanes PhD is a Pharmacist with expertise in Drugs Administration and Toxicity; Discovery of New Drugs; Cancer Treatment; Biochemical Analyzes and Hematological Analyzes. She writes and reviews content on these topics.
Dr Natália Marcéli Stephanes’ Highlights:
- Pharmacist at the Department of Health of Santa Catarina State, Brazil
- PhD with a focus on oncology treatment
- Years of experience in commercial pharmacy
- Bachelor, Master and PhD degrees in Pharmacy at the Federal University of Santa Catarina
Professional Experience:
From her undergraduate studies to her Master’s and Doctorate degrees in Pharmacy, Dr Natália Marcéli Stephanes has participated in numerous scientific studies in the field of oncology and onco-hematology at the University Hospital of the Federal University of Santa Catarina, Brazil. Her research has focused on understanding the molecular and biochemical bases of malignant neoplasms and investigating safer and more effective therapeutic alternatives.
Dr Natália Marcéli Stephanes has also served as an assistant professor of haematology for undergraduate students at the Federal University of Santa Catarina. Additionally, she held the position of professor of Hospital Pharmacy at the Qualificar Technical School in Brazil, where she developed instructional materials for use in the Pharmacy Postgraduate Program at the Leonardo Da Vinci University Center.
In addition to her academic experiences, Dr Natália Marcéli Stephanes possesses a strong expertise in commercial pharmacy, with in-depth knowledge of medications, their routes of administration, desired effects, adverse effects, and toxicity.
Currently, Dr Natália Marcéli Stephanes works as a Pharmacist at the Health Department of Santa Catarina State, where her role entails providing pharmaceutical scientific consulting services to judges.
Education:
- 2016 Bachelor in Pharmacy at the Federal University of Santa Catarina, Brazil
- 2018 Master in Pharmacy at the Federal University of Santa Catarina, Brazil
- 2023 PhD in Pharmacy at the Federal University of Santa Catarina, Brazil
The main publications of Dr Natália Marcéli Stephanes are:
Falchetti M ; Delgobo M, Zancanaro H, Almeida K, Das Neves RN, Dos Santos B, Stefanes NM, et al. Bishop Omics-based identification of an NRF2-related auranofin resistance signature in cancer: Insights into drug repurposing. Comput. Biol. Med [Internet]. 2023; 152:106347.
Feuser PM, Matos dos Santos PC, Cordeiro AP, Stefanes NM, Walter LO, Maioral MF, Santos-Silva MC, et al. Antineoplastic activity of free 4-nitrochalcone and encapsulated in poly(thioether-ester) nanoparticles obtained by thiol-ene polymerization in two human leukemia cell lines (Jurkat and K562). J Drug Deliv Sci Technol [Internet]. 2022; 67:102924.
Jacques AV, Stefanes NM, Walter LO, Perondi DM, Efe FL, Souza LFS, Sens L, et al. Synthesis of chalcones derived from 1-naphthylacetophenone and evaluation of their cytotoxic and apoptotic effects in acute leukemia cell lines. Bioorg. Chem [Internet]. 2021; 116:105315.
Duarte BF, Vieira DSC, Lisboa ML, Stefanes NM, Grando LJ, Santos-Silva MC. Características clínico-epidemiológicas de pacientes portadores de carcinoma de células escamosas de boca. Arquivos Catarinenses de Medicina. 2021; 50(2): 232–245.
Machado V, Jacques AV, Stefanes NM, Santos-Silva MC, Biavatti MW. Anti-leukemic activity of semisynthetic derivatives of Lupeol. Nat. Prod. Res. 2021; 35(22):4494-4501.
Bigolin A, Maioral MF, Stefanes NM, Mascarello A, Chiaradia-Delatorre LD, Nunes RJ, Yunes RA, et al. A novel sulfonamide derivative as a strong and selective apoptotic agent against hematological malignancies. Chem. Pap. 2020; 74:2965–2976.
Bigolin A, Maioral MF, Stefanes NM, Zatelli GA, Philippus AC, Falkenberg MB, Santos-Silva MC. Cytotoxic mechanisms of primin, a natural quinone isolated from Eugenia hiemalis, on hematological cancer cell lines. Anticancer Drugs. 2020; 31(7):709-717.
Maioral MF, Stefanes NM, Neufeldt PD, Chiaradia-Delatorre LD, Nunes RJ, Santos-Silva MC. Aldehyde biphenyl chalcones induce immunogenic apoptotic-like cell death and are promising new safe compounds against a wide range of hematologic cancers. Future Med. Chem. 2020; 12(8):673–688.
Perondi DM, Jacques AV, Stefanes NM, Maioral MF, Sens L, Pacheco LA, Cury NM, et al. A novel thiosemicarbazone as a promising effective and selective compound for acute leukemia. Anticancer Drugs. 2019; 30(8):p 828-837.
Rengifo AFC, Stefanes NM, Toigo J, Mendes C, Argenta DF, Dotto MER, Santos-Silva MC, et al. PEO-chitosan nanofibers containing carboxymethyl-hexanoyl chitosan/dodecyl sulfate nanoparticles loaded with pyrazoline for skin cancer treatment. Eur. Polym. J. 2019; 119:335-343.
Rengifo AFC, Stefanes NM, Toigo J, Mendes C, Santos-Silva MC, Nunes RJ, Parize AL, et al. A new and efficient carboxymethyl-hexanoyl chitosan/dodecyl sulfate nanocarrier for a pyrazoline with antileukemic activity. Mater. Sci. Eng. C [Internet]. 2019; 105:110051.
Maioral MF, Stefanes NM, Bigolin A, Zatelli GA, Philippus AC, Falkenberg MB, Santos-Silva MC. Miconidine acetate, a new selective and cytotoxic compound with synergic potential, induces cell cycle arrest and apoptosis in leukemia cells. Invest. New Drugs. 2019; 37:912–922.
Srefanes NM, Toigo J, Maioral MF, Jacques AV, Chiaradia-Delatorre LD, Perondi DM, Ribeiro AAB, et al. Synthesis of novel pyrazoline derivatives and the evaluation of death mechanisms involved in their antileukemic activity. Bioorg. Med. Chem. 2019; 27(2):375-382.
Maioral MF, Bodack CN, Stefanes NM, Bigolin A, Mascarello A, Chiaradia-Delatorre LD, Yunes RA, et al. Cytotoxic effect of a novel naphthylchalcone against multiple cancer cells focusing on hematologic malignancies. Biochim. 2017; 140:48-57.
You can view some of Dr Natália’s work below and links to her professional profile below.
Research Gate: https://www.researchgate.net/profile/Natalia-Stephanes
Linkedin: https://www.linkedin.com/in/nataliamarceli/
What is the best time of day to take Meloxicam?
You can take Meloxicam at any time of the day. There’s no specific time to take this medication, but it’s best to take it at the same time each day, whether in the morning or at night. Meloxicam is available in both OTC and prescription forms.
If your doctor has prescribed this medication, make sure you take it just as your doctor has recommended. If you’re using Meloxicam over the counter, you can take it at any time of the day.
If you’re confused as to which time is appropriate, you can take it after lunch. Meloxicam doesn’t really come with restrictions, but it’s best to take it after your meals.
This is because Meloxicam is an NSAID, and the entire class of these meds is associated with gastrointestinal side effects, which are more prominent when you take the medicine on an empty stomach or if you lie down immediately after taking it.
So, make sure you remember these things when taking Meloxicam and do not take it unnecessarily. If you’re not sure how many days you should take OTC Meloxicam, talk to your doctor or pharmacist.
Does the timing of taking Meloxicam affect drug efficacy?
The timing of taking Meloxicam may affect its efficacy. Meloxicam is a nonsteroidal anti-inflammatory drug (NSAID) commonly used to reduce pain and inflammation (1,2).
These drugs are associated with gastrointestinal side effects, which are more prominent when you take the medicine on an empty stomach or if you lie down immediately after taking it. This is why it is usually recommended to take Meloxicam with food to minimize the risk of stomach upset.
Taking it with food can also enhance its absorption and improve its effectiveness. However, it is important to follow the specific instructions provided by your healthcare professional or as mentioned on the medication label.
How to ensure the proper use of Meloxicam?
To ensure the proper use of Meloxicam, there are a few key points to keep in mind (3):
- Follow the prescribed dosage. Take Meloxicam exactly as prescribed by your healthcare professional.
- Do not exceed the recommended dose or take it more frequently than instructed.
- To minimize the risk of stomach upset, it is generally recommended to take Meloxicam with food.
- Inform your doctor about all the medications you are taking, including over-the-counter drugs and supplements.
- If you experience any unusual or severe side effects while taking Meloxicam, such as stomach pain, bleeding, or allergic reactions, notify your healthcare provider immediately.
- Inform your healthcare provider if you have any medical conditions, such as heart disease, high blood pressure, or kidney problems.
Always consult with your healthcare professional for personalized advice and guidance on the proper use of Meloxicam based on your specific health condition and needs.
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References
1.-
Ghlichloo I, Gerriets V. Nonsteroidal Anti-inflammatory Drugs (NSAIDs). 2023 May 1. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 Jan–. PMID: 31613522. https://www.ncbi.nlm.nih.gov/books/NBK547742
2.-
Shavlovskaya OA, Bokova IA, Shavlovskiy NI. Klinicheskie effekty meloksikama [Meloxicam clinical effects]. Zh Nevrol Psikhiatr Im S S Korsakova. 2022;122(1):36-42. Russian. doi: 10.17116/jnevro202212201136. PMID: 35175701. https://pubmed.ncbi.nlm.nih.gov/35175701/
3.-
Ogino K, Saito K, Osugi T, Satoh H. [Meloxicam (Mobic): a review of its pharmacological and clinical profile]. Nihon Yakurigaku Zasshi. 2002 Dec;120(6):391-7. Japanese. doi: 10.1254/fpj.120.391. PMID: 12528470. https://pubmed.ncbi.nlm.nih.gov/12528470/
