What are the effects of Cymbalta and Alcohol hangover? 

What are the effects of Cymbalta and alcohol hangover?

The harmful effects of Cymbalta and alcohol hangover include:

  • Impairment of sensory and motor coordination 
  • Suicidal thoughts or behaviour 
  • Cymbalta and alcohol toxicity
  • Gastrointestinal side effects 
  • Blackouts

Impairment of sensory and motor coordination

One of the most expected outcomes of Cymbalta and alcohol use is impairment of sensory and motor coordination. Both Cymbalta and alcohol affect your brain and alter the number of neurotransmitters. 

Cymbalta can enhance the excitatory ones, whereas alcohol may affect both excitatory and inhibitory neurotransmitters. This can affect your psychological functions to a great extent and may find it even difficult to maintain your balance (1). 

Cymbalta can also cause side effects like sleepiness and dizziness, which can become much more severe if you pair alcohol with this antidepressant. 

Suicidal thoughts or behaviour 

As Cymbalta is an antidepressant in nature, it actively controls the symptoms associated with depression symptoms. Alcohol, on the other hand, has depressing effects on the brain. 

If you take these two together excessively, alcohol will decrease the potency of your antidepressant and your depression level will most definitely spike. 

This can lead to suicidal behaviour and as the affected person does not think rationally at that very moment, suicidal behaviour could also be observed. 

Cymbalta and alcohol toxicity 

Both Cymbalta and alcohol are primarily metabolised by the liver. If you have excess amounts of both of the chemicals in your brain at the same time, it could put a lot of load on your liver. 

A chronic alcohol user or a person with hepatic insufficiency can get significantly affected as the liver will most likely not be able to function as well as it should and both Cymbalta and alcohol will start accumulating in your body. This leads to toxicity and it can result in life-threatening complications. 

Gastrointestinal side effects 

Both Cymbalta and alcohol can affect your gastrointestinal health and can cause symptoms like:

  • Nausea 
  • Vomiting 
  • Diarrhoea 
  • Abdominal pain
  • Abdominal tenderness or swelling

The combination can also affect people severely who struggle with some gastrointestinal diseases, like gastric and duodenal ulcers (2). In fact, studies have reported that excessive amounts of Cymbalta and alcohol can increase the risk of gastrointestinal bleeding in such patients. 


As I stated earlier, both Cymbalta and alcohol affect your central nervous system. In some cases, people may end up losing consciousness. It is not only dangerous in ways you’re probably thinking of right now, but it can cause physical injury, like head injury, bone fracture, bruises, etc if you fall on a hard surface.

What to do if you have taken Cymbalta and alcohol together? 

If you have taken Cymbalta and alcohol together and you feel unusual or your head starts to spin, immediately call your medical emergency helpline, especially if you’re alone. 

Although a glass or two of alcohol with Cymbalta may not make you lose consciousness, if you have taken a lot of it, you can easily lose your balance and hurt yourself. If you have taken the two together but you feel okay, that’s a good sign. 

However, you should not take any more than that and risk your health. Always remember, your health should be your first priority and everything else should be secondary. 

Cymbalta itself is not a drug of abuse and it can not get you high. However, it can cause disturbing side effects when combined with other medications that can be used for recreational purposes. So, make sure you take Cymbalta in the best possible way to make the most out of it.

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Antidepressants and alcohol: What’s the concern? [Internet]. Mayo Clinic; c1998-2023 [updated 2020 May 2; cited 2022 Nov 6]. Available from: https://www.mayoclinic.org/diseases-conditions/depression/expert-answers/antidepressants-and-alcohol/faq-20058231.


Bode C, Bode JC. Alcohol’s role in gastrointestinal tract disorders. Alcohol Health Res World. 1997;21(1):76-83. PMID: 15706765; PMCID: PMC6826790. Available from: https://pubmed.ncbi.nlm.nih.gov/15706765/

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