Should you take Effexor every other day? 

Should you take Effexor every other day? 

You should take Effexor every other day if your healthcare provider has asked you to. Antidepressants like Effexor are usually taken every single day for as long as recommended by a doctor. These medications are not only taken when needed like OTC medications. 

This is because antidepressants are not fast-acting medications and can take 4-6 weeks to kick in. These meds gradually balance the excitatory chemicals in your brain to counteract symptoms associated with depression and other mental health conditions.  

Some people may take longer than that to start observing noticeable changes in their condition. Most antidepressants, including Effexor, are prescribed to take once daily, either in the morning or at night. 

The timing of antidepressant administration can be different for different people as it can depend on the side effects Effexor causes. If you’re a new user, you may find the first few weeks of your treatment a bit difficult, as Effexor may cause a number of early side effects (1). 

However, the majority of these side effects begin to subside within a few weeks as your body adjusts to the medication. 

What are the dangers of skipping Effexor? 

If you don’t take Effexor and skip your doses, your antidepressant will not likely work the way it normally should. 

Intermittent dose administration can make your body take longer to adjust to the medication, which in turn will take much longer to manage your symptoms. This is for people who are new to Effexor. 

People who are well-adjusted on Effexor and have been taking this antidepressant for quite a while may experience disturbing side effects if they start skipping their doses. The side effects may include (2):

  • Headaches
  • Dizziness or lightheadedness
  • Nausea or vomiting
  • Diarrhoea or constipation
  • Insomnia or difficulty sleeping
  • Anxiety or nervousness
  • Agitation or irritability
  • Fatigue
  • Sweating
  • Tingling or numbness in the hands or feet
  • Visual disturbances, such as blurred vision
  • Hallucinations or delusions (in rare cases)

This is why you need to make sure that you take Effexor or any other antidepressant properly every day as long as your doctor recommends taking them. If you’re concerned about any of the side effects, discuss them with your doctor. 

Final words

To sum up, Effexor should be taken properly and just as directed by your mental healthcare professional to ensure a safe and effective therapeutic outcome. Antidepressants are usually taken once daily. The duration of treatment can vary, depending on the reason why you’re taking Effexor. 

Treatment with antidepressants can be a little uncomfortable during the first few weeks, but it does get better with it. If you are concerned about any side effects, please discuss them with your doctor. It is not recommended to skip your doses in order to manage side effects.

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PubChem [Internet]. Bethesda (MD): National Library of Medicine (US), National Center for Biotechnology Information; 2004-. PubChem Compound Summary for CID 5656, Venlafaxine; [cited 2023 Feb. 21]. Available from:


Parker G, Blennerhassett J. Withdrawal reactions associated with venlafaxine. Aust N Z J Psychiatry. 1998 Apr;32(2):291-4. doi: 10.3109/00048679809062742. PMID: 9588310. Available from:

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