Is Zoloft gluten-free? 

Is Zoloft gluten-free? 

Yes, Zoloft is gluten-free. This brand of Sertraline is known to be safely used in people with celiac disease as it does not contain gluten (1). However, the same cannot be said for generic Sertraline tablets or other brands because of the lack of research on this specific topic (2). 

The active ingredient of the drug itself does not contain gluten. It’s the pharmaceutical fillers that are used to manufacture the dosage form that can contain gluten in them. However, commonly prescribed brands of antidepressants, like Zoloft, Celexa, Lexapro, etc are gluten-free.

Most of the fillers are not produced by the drug manufacturers themselves, so the presence of gluten can not be fully confirmed. However, it’s best to ask your doctor or pharmacist for a safer option for you that would not trigger symptoms associated with your celiac disease. 

Potential risks of gluten-containing antidepressants for individuals with gluten sensitivity

Some potential risks of gluten-containing antidepressants for individuals with gluten sensitivity include (3):

Digestive Issues

Gluten sensitivity can cause gastrointestinal symptoms such as abdominal pain, bloating, diarrhoea, and constipation. If an individual with gluten sensitivity takes antidepressants containing gluten, it may trigger or worsen these digestive issues, leading to discomfort and disruption in their daily life.

Systemic Inflammation

Gluten sensitivity can activate an immune response in the body, leading to inflammation. Ingesting gluten-containing antidepressants may contribute to ongoing inflammation, potentially exacerbating symptoms associated with gluten sensitivity, such as joint pain, fatigue, and brain fog.

Malabsorption of Nutrients

Gluten sensitivity can impair the absorption of essential nutrients from the digestive system. If an individual with gluten sensitivity takes antidepressants containing gluten, it may further compromise nutrient absorption, potentially leading to nutritional deficiencies and associated health problems.

Increased Autoimmune Response

Gluten sensitivity is often linked to autoimmune disorders, where the immune system mistakenly attacks healthy tissues. 

Consuming gluten-containing antidepressants can potentially trigger or intensify the autoimmune response, worsening symptoms of autoimmune conditions and compromising overall health.

Emotional Well-being

For individuals with gluten sensitivity, consuming gluten can impact their mental and emotional well-being, leading to increased anxiety, depression, and mood disturbances. 

Ingesting gluten-containing antidepressants may further disrupt emotional balance, potentially counteracting the intended therapeutic effects of the medication.

Final words

To sum up, Zoloft is a gluten-free formulation and can be taken safely by people who are sensitive to gluten. However, a lot of antidepressant brands do contain gluten. 

It’s important for individuals with gluten sensitivity to be aware of the potential risks associated with gluten-containing antidepressants. 

Consulting with a healthcare professional is crucial to discuss alternatives and find gluten-free options that suit their specific needs and minimize potential risks.

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LABEL: ZOLOFT- sertraline hydrochloride tablet, film coated. ZOLOFT- sertraline hydrochloride solution, concentrate. DailyMed [Internet].


PubChem [Internet]. Bethesda (MD): National Library of Medicine (US), National Center for Biotechnology Information; 2004-. PubChem Compound Summary for CID 68617, Sertraline; [cited 2023 July 13]. Available from:


Catassi C. Gluten Sensitivity. Ann Nutr Metab. 2015;67 Suppl 2:16-26. doi: 10.1159/000440990. Epub 2015 Nov 26. PMID: 26605537.

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