Is Xanax bad for your kidneys? (3+ guidelines)

In this article, we will discuss whether Xanax affects kidneys, what research suggests, and what factors can affect kidney function while taking Xanax, precautions and guidelines for Xanax use to protect kidney function, and what to do if you are concerned about it.

Is Xanax bad for your kidneys?

Xanax is not necessarily bad for your kidneys. It is commonly prescribed for anxiety and panic disorders and belongs to the benzodiazepine class. The relationship between Xanax and kidney health has been a concern among healthcare professionals and patients.

However, it is important to note that very limited scientific research specifically links Xanax to kidney damage. Xanax acts on the central nervous system to relieve anxiety and is metabolized in the liver. So, it has a lower potential for direct kidney toxicity when compared to drugs primarily cleared through the kidneys.

What does research suggest?

While there may be limited evidence directly linking Xanax to kidney damage, it is crucial to consider the broader context of benzodiazepine use. Some studies have suggested that long-term use of benzodiazepines, like Xanax, may be associated with an increased mortality rate in patients with chronic kidney disease. (1)

According to another study, the effect of a 1.0 mg dose of Xanax was compared between 14 people; half were dialysis-dependent kidney patients, and half were healthy individuals. The result showed that chronic kidney failure does not significantly affect Xanax clearance from the body. (2)

However, because these studies have many complicated variables, it is difficult to determine a clear association between Xanax and kidney impairment.

What factors can affect kidney function while taking Xanax?

When you are using Xanax, certain factors can affect kidney function:

  • Dosage: High doses or long-term use of Xanax may increase the risk of kidney damage. It is essential to take Xanax at the same frequency and dosage as your healthcare professional prescribes.


  • Drug Interactions: Xanax can interact with other medications that might affect kidney function. Discuss all your medications with your doctor to ensure there are no adverse interactions.


  • Underlying health conditions: If you have pre-existing kidney problems or other health issues, it is crucial to consult with your healthcare provider. They can assess whether Xanax is suitable for you or recommend alternative treatments.


  • Individual variability: Individual factors like genetics can also influence the effect of Xanax on kidney function. Some people are more susceptible to the side effects of this medication. (3)

What to do to protect kidney function while using Xanax?

To minimize the potential risks associated with Xanax and protect your kidney health, consider the following precautions and guidelines:

  • Medical supervision: Always use Xanax under the supervision of a qualified healthcare professional. They can determine the appropriate dosage and duration for your specific condition.


  • Regular monitoring: If you are prescribed Xanax for an extended period, regular check-ups and kidney function tests may be advisable to detect any changes early.


  • Stay hydrated: Adequate hydration is essential for kidney health. Make sure you drink enough water daily and maintain a healthy diet.


  • Avoid alcohol: Alcohol can interact with Xanax and increase its toxicity, which can stress your kidneys more. It’s best to abstain from these while taking Xanax. (4)


  • Report side effects: If you experience any unusual symptoms, including changes in urination or any discomfort in the kidney area, contact your healthcare provider immediately.

What to do if Xanax is affecting your kidneys?

If you have concerns about the effect of Xanax on your kidneys, the first step is to discuss them with your healthcare provider. They can evaluate your situation and help you make informed decisions about your treatment plan.

It may involve lowering the dose of Xanax or exploring alternative treatments like mirtazapine, which has a different side effect profile than Xanax, to protect your kidney health. It is important to remember that the relationship between Xanax and kidney function is complex and may vary from person to person.


According to my knowledge and research, the link between Xanax and kidney health remains a topic of ongoing investigation. Medical guidance and regular monitoring are crucial when considering its use. I emphasize the importance of open communication with healthcare providers to ensure kidney health.

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Winkelmayer, W., Mehta, J., & Wang, P. (2007). Benzodiazepine use and mortality of incident dialysis patients in the United States. Kidney International, 72(11), 1388-1393.


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Huang Z, Xu Z, Wang H, Zhao ZQ, Rao Y. Influence of ethanol on the metabolism of alprazolam. Expert Opin Drug Metab Toxicol. 2018 Jun;14(6):551-559. doi: 10.1080/17425255.2018.1483338. PMID: 29848078.