Is Seroxat the Same as Prozac? (3 Differences)

This article will explore the differences between Seroxat and Prozac. It discusses their therapeutic uses, off-label uses, and potential side effects. Additionally, the article compares the withdrawal symptoms associated with these medications.

Lastly, the article will discuss considerations that physicians may take into account when deciding to prescribe one of these medications over the other.

Is Seroxat the same as Prozac?

Seroxat (paroxetine) and Prozac (fluoxetine) are not the same. While they are both Selective Serotonin Reuptake Inhibitors (SSRIs), belong to the same class of antidepressants, and have similar mechanisms of action, it is important to note that they are not identical.

They have different chemical structures, which can affect how they work in the body and individual responses to them. Moreover, despite being commonly prescribed for depression and anxiety disorders, there may be variations in their other approved indications and off-label uses.

Moreover, individuals may react differently to these medications based on their unique biochemistry and medical history. It is essential to consult a healthcare professional to determine the most suitable medication and dosage for an individual’s specific needs.

What are the differences between Seroxat and Prozac?

The differences between Seroxat and Prozac include:

Therapeutic uses

Seroxat is approved for the treatment of major depressive disorder (MDD), generalized anxiety disorder (GAD), panic disorder (PD), social anxiety disorder (SAD), obsessive-compulsive disorder (OCD), and post-traumatic stress disorder (PTSD). It is also approved to treat premenstrual dysphoric disorder (PMDD) [1].

Prozac is approved for the treatment of MDD, OCD, bulimia nervosa, and panic disorder. It is also approved for the treatment of premenstrual dysphoric disorder (PMDD) under the brand name Sarafem [2].

Both Seroxat and Prozac may be used off-label for conditions not specifically approved by regulatory authorities. Off-label uses of Prozac include [3]:

  • Social anxiety disorder (social phobia)
  • Post-traumatic stress disorder in adults
  • Borderline personality disorder
  • Raynaud phenomenon
  • Selective mutism.

On the other hand, Seroxat’s off-label uses include [4]:

  • Obsessive-compulsive disorder (OCD) in children and adolescents
  • Social anxiety disorder (SAD) in children and adolescents
  • Separation anxiety 
  • Dysthymia
  • Body dysmorphic disorder
  • Postpartum depression

Side effects

Common side effects associated with both Seroxat and Prozac may include nausea, diarrhea, dry mouth, drowsiness, insomnia, headaches, and sexual dysfunction. These side effects are generally mild and tend to improve over time [3,4].

However, these drugs can vary in frequencies and intensities of certain side effects. Specific side effects that may be more commonly associated with Seroxat include dizziness, tiredness, somnolence (excessive sleepiness), and weight gain [4].

On the other hand, Prozac may be more likely to cause nervousness, restlessness, and vivid dreams [3].


Seroxat’s withdrawal symptoms are more severe than Prozac’s, particularly anxiety, hostility, depression, and somatic symptoms [5].

Other withdrawal symptoms may include dizziness, fatigue, nausea, headache, sleep disturbances (such as vivid dreams or insomnia), and flu-like symptoms. Some people also report experiencing electric shock sensations [5].

On the other hand, withdrawal symptoms associated with Prozac (fluoxetine) tend to be milder and less frequent compared to Seroxat. Possible withdrawal symptoms for Prozac may include dizziness, fatigue, lethargy, gastrointestinal discomfort, headache, sleep disturbances, and mood changes [5].

What does research suggest?

A research study has compared the effectiveness of fluoxetine and paroxetine in treating different disorders for 12 weeks. In terms of the improvement of anxiety compared to baseline, during the twelve weeks, fluoxetine generally showed a slightly higher average improvement (52%) compared to paroxetine (50%).

After the first week of treatment, however, paroxetine demonstrated advantages in terms of agitation and psychic anxiety, with higher effectiveness percentages (49% and 18%, respectively) compared to fluoxetine (12% and 12%, respectively) [6].

Both medications showed similar success rates in treating depression, with paroxetine’s response rate at 67% and fluoxetine’s at 68.4%. When it comes to the average improvement of depression symptoms in comparison to baseline, fluoxetine had a slightly higher percentage (58%) compared to paroxetine (54%).

As for the side effects, some percentages varied. Diarrhea occurred in 12% of patients taking paroxetine, while it was reported in 19% of patients taking fluoxetine. Likewise, constipation was more common in the paroxetine group (18%) compared to the fluoxetine group (4%) [6].

Dyspepsia was more common in the paroxetine group as well (13% vs. 6%). Tremor (14% vs. 7%), sweating (14% vs. 6%), and nausea (38% vs. 32%) were also reported, demonstrating that paroxetine was more likely to cause these side effects [6].

In terms of weight loss, fluoxetine showed a higher percentage of weight loss (11.88%) compared to paroxetine (2.94%). Both groups experienced similar incidence rates of the remaining side events [6].

How to choose between taking Seroxat and Prozac?

Based on a patient’s medical history, allergies, and individual response to medications, a healthcare provider will assess which drug has a better safety profile and is more likely to be well-tolerated by the individual.

Moreover, in certain situations, specific indications may influence the choice between Prozac and Seroxat. However, only a healthcare professional can accurately assess your condition and determine which medication may be more appropriate for your specific needs.


In conclusion, Seroxat and Prozac are not the same, although they both belong to the class of SSRIs. According to my research, they have different chemical structures and variations in their approved indications and off-label uses.

After reviewing the scientific evidence, I concluded that both drugs can result in similar side effects and withdrawal symptoms. However, it is important to acknowledge that certain side effects and withdrawal symptoms may be more specific to one drug compared to the other.

From my perspective, this highlights the need for consulting a doctor when considering medications like Seroxat and Prozac. A physician can assess patient-specific variables such as safety profiles, hypersensitivity, and side effect sensitivity to choose the most suitable treatment plan for each patient.


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Highlights of Prescribing Information. Paxil (paroxetine) tablets, for oral use. PAXIL (paroxetine) oral suspension.


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