Is it okay to increase Cymbalta dose from 60 mg to 90 mg? 

Is it okay to increase Cymbalta dose from 60 mg to 90 mg? 

Yes, It is okay to start taking 90 mg of Cymbalta instead of 60 mg if your healthcare provider recommends you to. I would not recommend making this decision on your own as antidepressants should not be messed with. 

If your doctor thinks that your body tolerates Cymbalta well and now you need to shift to a higher dose for a better therapeutic response, he or she will increase the dose on their own. 

Usually, the treatment with antidepressants is started from the lowest effective dose as you can’t predict how an antidepressant will make you feel when you are taking it for the first time. 

Once it’s certain that you’re not allergic to the antidepressant and your body’s tolerating well, that’s when the dose is increased. 

What are the side effects associated with increasing Cymbalta dose from 60 mg to 90 mg? 

Cymbalta is generally associated with a number of side effects, as all antidepressants are. However, these side effects may become more prominent with an increased dose. 

In fact, some people start to experience side effects when their Cymbalta dose is increased. Some of the common side effects include (1):

  • Nausea 
  • Vomiting
  • Diarrhoea or Constipation
  • Acid reflux or heartburn
  • Abdominal pain 
  • Bloating 
  • Weight gain or weight loss 
  • Dry mouth 
  • Increased appetite or loss of appetite 
  • Frequent urination 
  • Night sweats and excessive sweating in general 
  • Headache 
  • Confusion 
  • Dizziness 
  • Drowsiness
  • Insomnia 
  • Forgetfulness 
  • Muscle pain 
  • Sexual side effects in both men and women 
  • Changes in estrogen levels in women (Rare)

According to research, psychological side effects are more commonly associated with higher doses like sleep disturbances, agitation, mood changes, forgetfulness, etc. 

Gastrointestinal side effects can also be significantly increased in some people after increasing the dose from 60 mg to 90 mg. 

What to do if you can’t cope with an increased Cymbalta dose? 

If you can’t cope with the increased dose, talk to your healthcare provider. Your doctor may first switch you to 75 mg instead of 90 mg. Antidepressants are not easy for everyone to take and these meds can become intolerable for quite a lot of people. 

This is why dose escalation should be slow and steady as your body should have enough time to adjust to the dose changes. Make sure you don’t stop taking Cymbalta abruptly. If you’re concerned about your side effects, just talk to your doctor. 

If your doctor thinks you should stop using this antidepressant, you will be provided with an appropriate taper schedule to prevent withdrawal symptoms. 

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National Library of Medicine. Duloxetine: MedlinePlus Drug Information [Internet]. [updated 15 Aug 2021; cited 29 Oct 2022]. Available from:

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