Does Cymbalta increase estrogen levels? 

Does Cymbalta increase estrogen levels?

Cymbalta may or may not increase estrogen levels in some people. This side effect is not considered a common one, but it has affected some people, including both men and women. 

Studies have shown that Cymbalta can rarely cause high levels of estrogen in men, which can trigger the growth of breasts in men and also cause pain and tenderness in them. 

Women, on the other hand, suffer in more ways as Cymbalta can ruin their menstrual cycle because of its effects on the levels of estrogen. If you think Cymbalta is causing such a hormonal imbalance in your body, reach out to your healthcare provider as soon as you can. 

What does research suggest? 

There aren’t enough research studies to explain why and how Cymbalta affects estrogen levels and who is more susceptible to it. Experts believe that different genetic compositions of different people can make them go through different side effects (1). 

The good thing is that this side effect is seen to be reversible when Cymbalta is discontinued. Some experts have also indicated that the concomitant use of Zoloft and some other medications may significantly alter your estrogen levels. 

Overall, more research is required to fully understand the incidence of this side effect and how common it is. 

What to do if Cymbalta causes an increase in estrogen levels? 

If Cymbalta is increasing your estrogen levels, talk to your healthcare provider. This side effect could be dose-dependent and higher doses may cause a more prominent rise in estrogen levels. 

Your doctor may try reducing your dose at first. If you don’t observe a difference and you continue to suffer, your doctor will most likely start tapering off the antidepressant. 

Always remember: Do not start Cymbalta abruptly. If your doctor thinks you need to stop the medication, he or she will suggest a proper taper schedule to prevent withdrawal symptoms as much as possible. 

Was this helpful?

Thanks for your feedback!



Wernicke JF, Gahimer J, Yalcin I, Wulster-Radcliffe M, Viktrup L. Safety and adverse event profile of duloxetine. Expert Opin Drug Saf. 2005 Nov;4(6):987-93. doi 10.1517/14740338.4.6.987. PMID: 16255658. Available from:

Find a supportive therapist who can help with Depression.

Discover the convenience of BetterHelp, an online therapy platform connecting you with licensed and accredited therapists specialized in addressing issues such as depression, anxiety, relationships, and more. Complete the assessment and find your ideal therapist within just 48 hours.


AskYourPharm is user-supported. We may earn a commission if you sign up for BetterHelp’s services after clicking through from this site