Is escitalopram vegan? (3+guide)

In this article, we will discuss escitalopram and its implications for individuals following a vegan lifestyle. We will delve into the ingredients of the medication, its manufacturing process, and whether it aligns with vegan principles. 

Is escitalopram vegan?

No, it’s not known whether escitalopram is vegan. While the active ingredient escitalopram is not derived from animals, the medication may contain inactive ingredients that could potentially be of animal origin (1).

Escitalopram, commonly known as Lexapro is a selective serotonin reuptake inhibitor (SSRI) primarily used to treat depression and generalised anxiety disorder (2). It works by increasing serotonin in the brain, a neurotransmitter crucial for mood regulation.

Veganism is a lifestyle choice that excludes the use of animal products for food, clothing, or any other purposes. This includes avoiding medications that contain animal-derived ingredients. Determining whether a medication is vegan is complex due to the presence of inactive ingredients that may be of animal origin (3).

Are the ingredients in escitalopram vegan?

The specific ingredients in escitalopram can vary depending on the manufacturer and the form of the medication. The active ingredient in escitalopram is escitalopram oxalate. The inactive ingredients in escitalopram tablets include talc, microcrystalline cellulose, silicon dioxide, and magnesium stearate (4).

While the active ingredient in escitalopram is not derived from animal origin, some of the inactive ingredients could potentially be of animal origin, like magnesium stearate, which could be derived from either plants or bovine tallow (5).

Animal-derived ingredients such as gelatin (from animal skin or bones), lactose (from cow’s milk), glycerin (from animal fats), and stearic acid (from bovine tallow) are often used in medications to facilitate the manufacturing process or improve stability or taste. These ingredients can present a challenge for vegans as they are obtained from animals or animal by-products.

To determine whether escitalopram is vegan, you can consult the medication package insert or reach out to the manufacturing pharmaceutical company for information on the excipients used

What are the ethical considerations for vegan consumers?

For vegans who need to take escitalopram, it’s important to weigh the benefits of the medication against its potential non-vegan status. The official definition of veganism states that vegan principles should be followed as far as possible and practicable.

Currently, no specific certifications or labels indicate whether a medication is vegan. Therefore, individuals interested in using vegan medications often need to search for each medication individually or consult with a healthcare provider or pharmacist.

The pharmaceutical industry has been making strides towards developing vegan-friendly alternatives. For instance, some manufacturers use pregelatinized starch as a vegan-friendly alternative to gelatin capsules (6). However, it is important to note that all medications have been tested on animals at some point during their development. This is a requirement for regulatory approval and is a consideration for individuals following a strict vegan lifestyle.

Supporting pharmaceutical companies that prioritize vegan-friendly practices can help drive industry change. This includes companies that develop animal-free alternatives to commonly used pharmaceutical ingredients and those that are committed to finding alternatives to animal testing.

Are there any alternative vegan-friendly medications?

For those seeking vegan alternatives to escitalopram, some antidepressants have been identified as suitable for vegans. These include sertraline tablets, venlafaxine tablets (but not capsules), fluoxetine liquid (but not capsules or tablets), and imipramine mixtures (but not tablets) (7). Additionally, natural antidepressants like St. John’s wort and S-adenosylmethionine may be worth considering.

Final Words

While escitalopram does not appear to contain animal-derived active ingredients, some inactive ingredients in the tablets could potentially be of animal origin. Therefore, it is crucial for individuals following a vegan lifestyle to consult with their pharmacist to make informed decisions about their medication. As the demand for vegan medication increases, the pharmaceutical industry will likely continue to adapt and provide more options for those who strive for a compassionate and sustainable life. By researching and seeking expert advice, you can make informed decisions that harmonize your mental health treatment and your ethical values.

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References

1.-

Highlights of prescribing information: Accessdata.fda.gov. https://www.accessdata.fda.gov/drugsatfda_docs/label/2023/021323s055,021365s039lbl.pdf

2.-

Culpepper L. Escitalopram: A New SSRI for the Treatment of Depression in Primary Care. Prim Care Companion J Clin Psychiatry. 2002 Dec;4(6):209-214. doi: 10.4088/pcc.v04n0601. PMID: 15014711; PMCID: PMC315490. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC315490/

3.-

Fuller SJ, Brown A, Rowley J, Elliott-Archer J. Veganism and eating disorders: assessment and management considerations. BJPsych Bull. 2022 Apr;46(2):116-120. doi: 10.1192/bjb.2021.37. PMID: 33928893; PMCID: PMC9074139. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9074139/

4.-

Lexapro (escitalopram oxalate) Tablets/Oral Solution. Accessdata.fda.gov. https://www.accessdata.fda.gov/drugsatfda_docs/label/2009/021323s032%2C021365s023lbl.pdf

5.-

Hamad ML, Gupta A, Shah RB, Lyon RC, Sayeed VA, Khan MA. Functionality of magnesium stearate derived from bovine and vegetable sources: dry granulated tablets. J Pharm Sci. 2008 Dec;97(12):5328-40. doi: 10.1002/jps.21381. PMID: 18351597.. https://pubmed.ncbi.nlm.nih.gov/18351597/

6.-

Prakash A, Soni H, Mishra A, Sarma P. Are your capsules vegetarian or nonvegetarian: An ethical and scientific justification. Indian J Pharmacol. 2017 Sep-Oct;49(5):401-404. doi: 10.4103/ijp.IJP_409_17. PMID: 29515283; PMCID: PMC5830853. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5830853/

7.-

Singsit S, Naik PC. Remember the depressed vegetarian. The British Journal of Psychiatry. Cambridge University Press; 2001;178(2):184. https://www.cambridge.org/core/journals/the-british-journal-of-psychiatry/article/remember-the-depressed-vegetarian/6401E2ADC40A6FBDD82AB328BB680114

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