how long does it take for Synvisc-One to work? (+1 factors)

In this article, we will discuss how long it takes for Synvisc-One to work. We will also discuss some alternatives if Synvisc-One does not effectively reduce the osteoarthritis pain.

How long does it take for Synvisc-One to work?

Synvisc-One shows osteoarthritic pain relief after the first injection. However, Synvisc-One may take 8-12 weeks to give the greatest relief from osteoarthritic pain. Some patients have reported a reduction in pain after 4 weeks of injection (1).

Therefore, Synvisc-One onset of action varies between individuals. Although all patients respond variably to the treatment, Synvisc-One may provide up to six months of osteoarthritic pain relief after the first dose (2).

The injection may be repeated after six months, depending upon the severity of the disease. As Synvisc-One is injected directly into the knee joint, your healthcare provider will give you this injection.

Inform your doctor if you experience any side effects after Synvisc-One administration, including pain, swelling, redness, or fluid retention around the knee. Do not use this injection if you are allergic to hyaluronan-based products.

How to know if Synvisc-One is working?

You may get osteoarthritic pain relief after the first injection of Synvisc-One. Synvisc-One also reduces stiffness in the knee, improves knee function, and reduces joint swelling. The effect may last up to 6 months (2).

It is recommended that you refrain from physical activities, exercise, or putting undue stress on your knee for approximately 48 hours after taking the injection. However, walking, standing, and other routine activities are permitted.

What does research suggest?

In one of the randomized, controlled clinical studies, 112 patients showed significant improvement in osteoarthritic pain relief, swelling, and mobility for up to 6 months after receiving Synvisc-One. The patients reported no side effects after the injection (2).

In one of the case reports, the use of Synvisc-One caused bilateral joint pain and swelling in a 72-year-old man. The elevated inflammatory markers indicated systemic inflammatory polyarthritis after 2 days of injecting Synvisc-One (3).

Factors affecting the time taken by Synvisc-One to work

Some factors may delay the time taken by Synvisc-One to work properly. You should follow the dosage regimen of Synvisc-One as decided by your doctor to get the most benefit.

Factor Reason
Individual variability Some individuals feel symptomatic pain relief after the first injection of Synvisc-One. However, others may experience pain relief after 8-12 weeks of treatment. These differences may be attributed to genetics, changes in metabolism, and the overall health status of the patient.
Incorrect route of administration Synvisc-One needs only be administered in the knee. You should always consult your healthcare provider for proper administration of Synvisc-One. Synvisc-One has not been tested to show pain relief if administered in other joints apart from the knee.
Drug interaction Topical benzalkonium chloride and cetylpyridinium are known to interact with Synvisc-One. These drugs may prevent Synvisc-One injection from working properly.

What to do if Synvisc-One does not work?

In case Synvisc-One is not working for you or you feel side effects are affecting your quality of life, you may ask your doctor for other possible clinical interventions.

Talk to your doctor

If Synvisc-One is not working for you and you feel that your symptoms are the same even after prolonged use, talk to your doctor. You should discuss your condition with the doctor, including adherence to Synvisc-One and dosing frequency.

Your doctor will identify possible reasons as to why Synvisc-One is not working. Open communication with your doctor about lifestyle factors such as drug abuse is important. Alternatively, your doctor may explore alternative options for you.

Alternatives to Synvisc-One

Synvisc-One can be alternated with intra-articular corticosteroid injections. Corticosteroids have a quicker onset of action but a shorter duration as compared to Synvisc-One. It is often used as an adjunct therapy for the relief of moderate to severe pain (4).

Alternatively, your doctor may prescribe intraarticular platelet-rich plasma injections instead of Synvisc-One. These injections are known to reduce osteoarthritic pain while improving knee mobility and knee function (4).

As a pharmacist, I would advise you to follow the directions of your doctor for the safe and effective use of Synvisc-One. Do not try to inject Synvisc-One yourself. If you experience pain, swelling, or redness at the injection site, inform your doctor.

You may take acetaminophen (a nonsteroidal anti-inflammatory drug) with Synvisc-One for symptomatic relief of osteoarthritis pain (5). You can also use diclofenac gel, available as 1% w/v Voltaren gel or Aleve arthritis gel.

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Kuropatkin GV, Ahtyamov IF, Stanislav ML, Kushnir VA, Belenkiy IG, Kopenkin SS, Tamazyan VO, Vezikova NN, Klyuchevskiy VV. Evaluation of safety and efficacy of Hylan GF 20 (Synvisc-One®) in patients with knee osteoarthritis in clinical practice. NN Priorov Journal of Traumatology and Orthopedics. 2020 Oct 8;27(2):36-44.


Sun SF, Hsu CW, Lin HS, Liou IH, Chen YH, Hung CL. Comparison of single intra-articular injection of novel hyaluronan (HYA-JOINT Plus) with synvisc-one for knee osteoarthritis: a Randomized, Controlled, Double-Blind Trial of Efficacy and Safety. JBJS. 2017 Mar 15;99(6):462-71.


Kocak D, Annaswamy T, Chong S, Arora R. Development of systemic inflammatory polyarthritis after zygapophyseal joint injection with hylan GF 20 (synvisc-one). American Journal of Physical Medicine & Rehabilitation. 2018 Feb 1;97(2):147-9.


Ayhan E, Kesmezacar H, Akgun I. Intraarticular injections (corticosteroid, hyaluronic acid, platelet rich plasma) for the knee osteoarthritis. World journal of orthopedics. 2014 Jul 7;5(3):351.


Euppayo T, Punyapornwithaya V, Chomdej S, Ongchai S, Nganvongpanit K. Effects of hyaluronic acid combined with anti-inflammatory drugs compared with hyaluronic acid alone, in clinical trials and experiments in osteoarthritis: a systematic review and meta-analysis. BMC Musculoskeletal Disorders. 2017 Dec;18:1-4.