How long does Adipex stay in your urine? (3+ factors to be considered)
By
Dr Natalia Marceli Stephanes (PhD)
Author bio
Dr Natália Marcéli Stephanes PhD is a Pharmacist with expertise in Drugs Administration and Toxicity; Discovery of New Drugs; Cancer Treatment; Biochemical Analyzes and Hematological Analyzes. She writes and reviews content on these topics.
Dr Natália Marcéli Stephanes’ Highlights:
- Pharmacist at the Department of Health of Santa Catarina State, Brazil
- PhD with a focus on oncology treatment
- Years of experience in commercial pharmacy
- Bachelor, Master and PhD degrees in Pharmacy at the Federal University of Santa Catarina
Professional Experience:
From her undergraduate studies to her Master’s and Doctorate degrees in Pharmacy, Dr Natália Marcéli Stephanes has participated in numerous scientific studies in the field of oncology and onco-hematology at the University Hospital of the Federal University of Santa Catarina, Brazil. Her research has focused on understanding the molecular and biochemical bases of malignant neoplasms and investigating safer and more effective therapeutic alternatives.
Dr Natália Marcéli Stephanes has also served as an assistant professor of haematology for undergraduate students at the Federal University of Santa Catarina. Additionally, she held the position of professor of Hospital Pharmacy at the Qualificar Technical School in Brazil, where she developed instructional materials for use in the Pharmacy Postgraduate Program at the Leonardo Da Vinci University Center.
In addition to her academic experiences, Dr Natália Marcéli Stephanes possesses a strong expertise in commercial pharmacy, with in-depth knowledge of medications, their routes of administration, desired effects, adverse effects, and toxicity.
Currently, Dr Natália Marcéli Stephanes works as a Pharmacist at the Health Department of Santa Catarina State, where her role entails providing pharmaceutical scientific consulting services to judges.
Education:
- 2016 Bachelor in Pharmacy at the Federal University of Santa Catarina, Brazil
- 2018 Master in Pharmacy at the Federal University of Santa Catarina, Brazil
- 2023 PhD in Pharmacy at the Federal University of Santa Catarina, Brazil
The main publications of Dr Natália Marcéli Stephanes are:
Falchetti M ; Delgobo M, Zancanaro H, Almeida K, Das Neves RN, Dos Santos B, Stefanes NM, et al. Bishop Omics-based identification of an NRF2-related auranofin resistance signature in cancer: Insights into drug repurposing. Comput. Biol. Med [Internet]. 2023; 152:106347.
Feuser PM, Matos dos Santos PC, Cordeiro AP, Stefanes NM, Walter LO, Maioral MF, Santos-Silva MC, et al. Antineoplastic activity of free 4-nitrochalcone and encapsulated in poly(thioether-ester) nanoparticles obtained by thiol-ene polymerization in two human leukemia cell lines (Jurkat and K562). J Drug Deliv Sci Technol [Internet]. 2022; 67:102924.
Jacques AV, Stefanes NM, Walter LO, Perondi DM, Efe FL, Souza LFS, Sens L, et al. Synthesis of chalcones derived from 1-naphthylacetophenone and evaluation of their cytotoxic and apoptotic effects in acute leukemia cell lines. Bioorg. Chem [Internet]. 2021; 116:105315.
Duarte BF, Vieira DSC, Lisboa ML, Stefanes NM, Grando LJ, Santos-Silva MC. Características clínico-epidemiológicas de pacientes portadores de carcinoma de células escamosas de boca. Arquivos Catarinenses de Medicina. 2021; 50(2): 232–245.
Machado V, Jacques AV, Stefanes NM, Santos-Silva MC, Biavatti MW. Anti-leukemic activity of semisynthetic derivatives of Lupeol. Nat. Prod. Res. 2021; 35(22):4494-4501.
Bigolin A, Maioral MF, Stefanes NM, Mascarello A, Chiaradia-Delatorre LD, Nunes RJ, Yunes RA, et al. A novel sulfonamide derivative as a strong and selective apoptotic agent against hematological malignancies. Chem. Pap. 2020; 74:2965–2976.
Bigolin A, Maioral MF, Stefanes NM, Zatelli GA, Philippus AC, Falkenberg MB, Santos-Silva MC. Cytotoxic mechanisms of primin, a natural quinone isolated from Eugenia hiemalis, on hematological cancer cell lines. Anticancer Drugs. 2020; 31(7):709-717.
Maioral MF, Stefanes NM, Neufeldt PD, Chiaradia-Delatorre LD, Nunes RJ, Santos-Silva MC. Aldehyde biphenyl chalcones induce immunogenic apoptotic-like cell death and are promising new safe compounds against a wide range of hematologic cancers. Future Med. Chem. 2020; 12(8):673–688.
Perondi DM, Jacques AV, Stefanes NM, Maioral MF, Sens L, Pacheco LA, Cury NM, et al. A novel thiosemicarbazone as a promising effective and selective compound for acute leukemia. Anticancer Drugs. 2019; 30(8):p 828-837.
Rengifo AFC, Stefanes NM, Toigo J, Mendes C, Argenta DF, Dotto MER, Santos-Silva MC, et al. PEO-chitosan nanofibers containing carboxymethyl-hexanoyl chitosan/dodecyl sulfate nanoparticles loaded with pyrazoline for skin cancer treatment. Eur. Polym. J. 2019; 119:335-343.
Rengifo AFC, Stefanes NM, Toigo J, Mendes C, Santos-Silva MC, Nunes RJ, Parize AL, et al. A new and efficient carboxymethyl-hexanoyl chitosan/dodecyl sulfate nanocarrier for a pyrazoline with antileukemic activity. Mater. Sci. Eng. C [Internet]. 2019; 105:110051.
Maioral MF, Stefanes NM, Bigolin A, Zatelli GA, Philippus AC, Falkenberg MB, Santos-Silva MC. Miconidine acetate, a new selective and cytotoxic compound with synergic potential, induces cell cycle arrest and apoptosis in leukemia cells. Invest. New Drugs. 2019; 37:912–922.
Srefanes NM, Toigo J, Maioral MF, Jacques AV, Chiaradia-Delatorre LD, Perondi DM, Ribeiro AAB, et al. Synthesis of novel pyrazoline derivatives and the evaluation of death mechanisms involved in their antileukemic activity. Bioorg. Med. Chem. 2019; 27(2):375-382.
Maioral MF, Bodack CN, Stefanes NM, Bigolin A, Mascarello A, Chiaradia-Delatorre LD, Yunes RA, et al. Cytotoxic effect of a novel naphthylchalcone against multiple cancer cells focusing on hematologic malignancies. Biochim. 2017; 140:48-57.
You can view some of Dr Natália’s work below and links to her professional profile below.
Research Gate: https://www.researchgate.net/profile/Natalia-Stephanes
Linkedin: https://www.linkedin.com/in/nataliamarceli/
This article will discuss the approximate stay time of Adipex in urine. We will also discuss some factors that may affect this time duration in some individuals and how one can ensure the safe and effective use of Adipex.
How long does Adipex stay in your urine?
Adipex (Phentermine) can stay in your urine for about 48-92 hours (2-4 days) (1). The terminal half-life of this medication is 20 hours, but the process of elimination can be carried out more rapidly if the urine is acidic (1).
This is because acidic urine can enhance the degradation of the drug and its subsequent removal from the body. It can also make it more soluble in urine.
Since Adipex is 80% removed via urine in an unchanged form, the drug’s half-life reduces from 20 hours to 7-8 hours in case of acidic urine (pH less than 5). (1)
However, it’s important to note that the exact time duration can vary from person to person, as different factors could affect it – like metabolism, dosage strength, and individual differences.
Factors affecting the stay time of Adipex in your urine
The following factors can affect the stay time of Adipex in your urine (1):
- Metabolism – How fast your body processes the drug can impact how long it stays in your system.
- Dosage – Higher Adipex doses can take longer to eliminate.
- Frequency – the more frequently you use Adipex, the longer it stays in your urine.
- Hydration – Drinking plenty of water can help flush the drug out of your body. Frequent urination can rapidly remove the drug.
- Liver and kidney functions – These are the primary organs responsible for drug elimination. If these organs don’t work properly, the drug could stay longer in your system overall.
- Use of other medications – Some medications can interact with Adipex, either prolonging or shortening its presence in your system.
These factors can vary from person to person, as each individual is unique and can have different factors affecting their health.
How to address Adipex showing up on a drug test concern?
If you’re concerned about Adipex showing up on a drug test or making you fail one, please talk to your healthcare provider.
Adipex does not generally show up on a drug test, but in some cases, it has caused a false positive for Amphetamines and has shown up as Adderall (2). This can cause a person to be concerned about going for a drug test while taking this medication.
The best way to deal with this situation is to inform the drug testing authority about all the medications you’re currently taking before the test. You can also submit your prescription as proof to the authority.
False positives are common and even OTC medications can cause them. This is why there is nothing to worry about as long as you’re just following your doctor’s directions and taking prescription medications.
How to ensure the safe and effective use of Adipex?
The following points are important to ensure the safe and effective use of Adipex (3):
- Take Adipex exactly as prescribed by your healthcare provider.
- Drink plenty of water while taking the medication.
- Make sure you follow a good diet and exercise regimen to enhance the effects of Adipex.
- Keep an eye out for any side effects and report them to your doctor.
- Avoid the use of alcohol with Adipex.
- Take Adipex early in the day to prevent insomnia at night.
- Keep a record of your weight loss journey to monitor the effectiveness of Adipex.
Conclusion
In this article, we have discussed the approximate stay time of Adipex in urine. We have also discussed some factors that can affect the time duration and what you should do if you’re concerned about getting a false positive on a drug test.
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References
1.-
PubChem [Internet]. Bethesda (MD): National Library of Medicine (US), National Center for Biotechnology Information; 2004-. PubChem Compound Summary for CID 4771, Phentermine; [cited 2023 Aug. 21]. Available from: https://pubchem.ncbi.nlm.nih.gov/compound/Phentermine
2.-
Alyson Schwebach, Jennifer Ball. Urine Drug Screening: Minimizing False Positives and False Negatives to Optimize Patient Care. US Pharm. 2013;38(12):1-6. Available at: https://www.uspharmacist.com/article/urine-drug-screening-minimizing-false-positives-and-false-negatives-to-optimize-patient-care
3.-
LABEL: ADIPEX-P- phentermine hydrochloride tablet. ADIPEX-P- phentermine hydrochloride capsule. DailyMed [Internet]. Available from: https://dailymed.nlm.nih.gov/dailymed/getFile.cfm?setid=f5b2f9d8-2226-476e-9caf-9d41e6891c46&type=pdf
