How does trazodone 50mg make you feel? (3+ benefits)

In this article, we will discuss how trazodone 50mg makes a person feel. Furthermore, we’ll discuss its onset and duration of action, its effects on different physiological functions of the body, the recommended dose, potential side effects of trazodone 50mg and precautionary measures while taking trazodone.

How does trazodone 50mg make you feel?

The specific feelings and experiences from taking trazodone 50mg may vary among individuals. Trazodone is approved by the FDA for the treatment of major depressive disorder. It is also used off-label as a sedative for the treatment of insomnia at lower doses like 50mg to promote sleep. However, the doses are adjusted based on individual conditions and responses. (1)

Trazodone is classified as a serotonin modulator. It exerts its effects by increasing the levels of serotonin in the brain which is an important neurotransmitter, responsible for playing various crucial roles in different physiological processes of the body including mood regulation to reduce the symptoms of depression and improve sleep quality. (1)

Everyone is unique in terms of brain chemistry and how they respond to medications. Some people may find trazodone more effective and tolerant in managing symptoms with minimal side effects while others may experience more pronounced effects. It’s important to consult your doctor before starting the medication and follow the appropriate dosage provided by them. 

Is trazodone 50mg suitable for treating depression or anxiety?

Trazodone is typically prescribed by doctors to treat depression but the starting doses for major depressive disorders may be slightly higher than the dose of 50mg, usually, it is 150mg per day. However, people are different and everyone may not respond the same to the specific dose of trazodone. Some may experience significant intended outcomes at 50mg whereas others may require a higher dose. (3)

Trazodone is not approved by the FDA as an anxiolytic and it is not considered a first-line treatment for anxiety disorders but it might have some anxiolytic effects due to its impact on serotonin which makes it useful in reducing anxiety in depressed patients. (1,3)

While adjusting the dose, your healthcare provider assesses several factors to ensure the safety and efficacy of the intended treatment plan such as how severe your depression is, if you have any other existing health condition and potential interactions with other medications if you’re taking any. 

Can trazodone 50mg improve sleep quality?

Yes, trazodone at a lower dose such as 50mg is often prescribed off-label to insomniac people to improve their sleep quality. While trazodone’s primary function is to be used as an antidepressant, however, it has sedative properties because of the effect of serotonin, which is beneficial for individuals experiencing difficulty falling asleep or staying asleep. (2)

Trazodone is normally prescribed in lower doses (50mg or 100mg) for the treatment of insomnia, especially when other sleep interventions or medications have not been effective and useful in promoting sleep. It may help individuals fall asleep faster and stay asleep throughout the night. Some individuals may find trazodone 50mg effective in improving their sleep quality and helping get rid of insomnia with minimal side effects. (2)

Can trazodone 50mg affect cognitive function or memory?

Trazodone, especially at lower doses of 50mg is generally considered less likely to cause significant cognitive impairment or memory issues in people compared to some other medications or trazodone itself at higher doses. However, individuals reactions to medications can vary and some may still be sensitive and prone to experience cognitive side effects at low doses. (4)

Common side effects of trazodone, even at the 50mg dose may include dizziness, drowsiness or lightheadedness. While these side effects are not considered to be directly related to cognitive function or memory, they can potentially affect alertness and concentration, especially when you have just started the medication and your body is not yet adjusted to the dose. These side effects are not that harmful at low doses and may go away on their own over time. (4)

It’s crucial to keep in mind that trazodone 50mg is usually prescribed at bedtime for sedative purposes to avoid disruptions in cognitive functions and wakefulness during the daytime. 

How long does it take for trazodone 50mg to start working?

The onset of action for trazodone can vary from person to person. When used for depression it may take several weeks to produce the full therapeutic effects. However, when trazodone is prescribed for sleep-related issues at lower doses, such as 50mg, the sedative effects can be noticeable sooner. (5)

Some individuals can experience its sedative effects within the first few days of starting the medication while others may take some time to get adjusted to the dose and feel relaxed with reduced insomnia. If trazodone is prescribed for sleep, it is usually recommended to take it shortly before bedtime to facilitate a smoother transition into sleep. 

It’s essential to keep in mind that the onset of action of trazodone, like many other medications can be influenced by various individual factors. These factors play a crucial role in contributing to the variability in how quickly a person may start experiencing the therapeutic effects or side effects of trazodone. These factors may include a person’s metabolism, body weight and composition, age, liver and kidney functions, genetic makeup, any underlying health conditions and individual sensitivity. (5)

What are the potential side effects of trazodone 50mg?

Trazodone, including at a dose of mg can have some side effects. Some individuals may tolerate the medication well and not necessarily experience the side effects. Common side effects may include: (1)

• Drowsiness or dizziness
• Dry mouth
• Blurred vision
• Constipation
• Nausea or upset stomach
• Headache
• Changes in blood pressure (High or low)
• Nervousness or anxiety
• Priapism (unusually long and painful erection)
• Serotonin syndrome (symptoms include, hallucinations, confusion, restlessness, seizures or tremors, muscle rigidity, fever etc)

What are the precautionary measures while taking trazodone 50mg?

While taking trazodone 50mg, it’s important to follow certain precautionary measures for safe and effective use of the medication. Here are some key precautions: (1,5)

Follow healthcare provider instructions: 

Take trazodone exactly as prescribed by your doctor. Do not change the dosage or stop taking it without consulting them.

Timing of administration: 

If your doctor has prescribed trazodone 50mg for sleep, ensure to take it at the same time each night, usually shortly before bedtime.

Avoid alcohol and smoking: 

Limit or avoid the consumption of alcohol while taking trazodone as it may enhance the sedative effects of the medication and increase the risk of overall side effects. 

Be cautious with other medications: 

Inform your doctor about all the medications you’re taking including prescription medications, over-the-counter drugs and herbal supplements or if you are allergic to any ingredients as trazodone can interact with certain substances and cause side effects.

Monitor side effects: 

Be vigilant and keep an eye on how your body is responding to the medication. Be aware of all the potential side effects like excessive drowsiness, blurred vision etc and inform your doctor. 

Inform about pregnancy or breastfeeding: 

If you’re pregnant, planning to conceive or breastfeeding, it’s essential to inform your healthcare provider before starting the medication as its safety is not well established in such situations.

Suicidal thoughts: 

Like many antidepressants, trazodone also carries the warning about an increased risk of suicidal thoughts especially in younger population aged less than 25. Pay attention to changes in moods or thoughts and seek immediate medical attention along with professional counselling.

As a pharmacist, in my opinion, taking trazodone at a low dose of 50mg is usually well-tolerated with minimal side effects profile in the majority of depressed and insomniac individuals. Just stick to the instructions provided by your doctor and adopt a healthy lifestyle rather being solely relying on the drug. Monitor your symptoms and schedule time-to-time follow-ups with your doctor. 

References