Can Trazodone cause high blood pressure? 

Can Trazodone cause high blood pressure? 

Trazodone may or may not affect your blood pressure. Most commonly Trazodone is associated with a slow heart rate and blood pressure. However, opposite effects have also been reported. 

Experts believe that these effects can depend on a lot of other factors like age, dose, frequency, genetics, etc. People on higher doses or people who accidentally take more of the prescribed dose may suffer from arrhythmia and increased blood pressure. 

However, it can also trigger heart-sinking feelings and low blood pressure. Make sure you monitor your side effects and report them to your healthcare provider. 

What does research suggest?

There is limited research on the harmful effects of Trazodone on your blood pressure. Several studies have indicated that Trazodone is not a cardiotoxic antidepressant. It does not worsen the symptoms of a cardiac condition and can be used safely in people with heart diseases (1).  

However, studies have also suggested that Trazodone should be used at a low dosage strength in cardiac patients or patients who suffer from hypertension. This is because higher doses can increase heart rate and blood pressure. 

Researchers have also indicated that people respond differently to medications and they can experience different types of side effects.  

Factors like the patient’s age, dosage strength, frequency, overall duration of treatment, and presence of any underlying health condition can make a difference. 

What to do if Trazodone increases your blood pressure? 

If Trazodone is affecting your blood pressure, talk to your healthcare provider. Your doctor will determine if it’s safe for you to continue using this antidepressant and if there’s anything that can prevent your blood pressure to go up. 

If possible, your doctor may decrease your dose a little bit to help you adjust better to Trazodone. This antidepressant can make you feel generally unwell. However, most of the side effects are expected to go away once your body adjusts. 

If the drug continues to affect your heart rate and blood pressure, your doctor will most likely switch you to another antidepressant. Make sure you don’t stop using Trazodone abruptly. If the antidepressant needs to be stopped, your doctor will suggest the best possible way to do so. 

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Himmelhoch JM, Schechtman K, Auchenbach R. The role of trazodone in the treatment of depressed cardiac patients. Psychopathology. 1984;17 Suppl 2:51-63. doi: 10.1159/000284093. PMID: 6201941. Available from:

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