By
Dr Drielli Vital-Fujii (PhD)
| Reviewed by
Dr Drielli Vital-Fujii (PhD)
Page last updated:
08/01/2024 |
Next review date:
08/01/2026
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The contents of this article are fact-based except otherwise stated within the article.
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Author bio
Dr Drielli Vital-Fujii, PhD, is a Pharmacist with expertise in Drug Design and Development, Enzymes, Molecular Modelling, and Photodynamic Therapy. She writes and reviews content on these topics.
Dr Drielli Vital-Fujii’s Highlights:
- Postdoctoral fellow at the Department of Biochemistry at the University of São Paulo, emphasizing therapy of neglected diseases using light.
- PhD in Pharmaceutical Sciences focusing on drug design and development at the Faculty of Pharmaceutical Sciences of the University of São Paulo.
- Six months as an international researcher at the Center for Discovery and Innovation in Parasitic Diseases (University of California San Diego)
- Master’s degree in Pharmaceutical Sciences focusing on drug design and development at the Faculty of Pharmaceutical Sciences of the University of São Paulo.
- Bachelor of Pharmacy at the University of Mogi das Cruzes – São Paulo / Brazil
Professional Experience:
2012 – 2018 Project manager at University of São Paulo – Pharmacy Department
Dr Drielli Vital-Fujii has worked with computational studies, synthesis, biological evaluation, design, and development of new inhibitor candidates for Chagas Disease and Leishmaniasis.
2017 – 2017 International research fellow at University of California San Diego Skaggs School of Pharmacy and Pharmaceutical Sciences – Center for Discovery and Innovation in Parasitic Diseases.
She used Virtual Screening (VS) and High-Throughput Screening (HTS) Integration in the Discovery of new drugs against neglected tropical diseases (NTDs).
2018 – 2019 Faculdades Oswaldo Cruz
Dr Drielli Vital-Fujii was a professor in the Faculty of Pharmacy, teaching the subjects of Pharmaceutical Chemistry and Drug Development.
2019 – 2021 Researcher in Biochemistry University of São Paulo – Biochemistry Department
She applied Photodynamic Therapy in Leishmaniasis Treatment, mentored undergraduate students in scientific activities, and wrote, executed, translated, and reported scientific projects with funding agencies.
2023-2023 UniPiaget – University Center.
Dr Drielli Vital-Fujii was a Biology, Nutrition, Physiotherapy, and Pharmacy professor.
Education:
2018 -2021 Postdoctoral at the Department of Biochemistry at the University of São Paulo
2013 -2018 PhD of Science: Drugs and Medicines at Department of Pharmacy at University of São Paulo
2012 -2013 M.Sc. of Sciences: Drugs and Medicines at the Department of Pharmacy at the University of São Paulo
2005-2008 Bachelor of Pharmacy at the University of Mogi das Cruzes
The leading publications of Dr Drielli Vital-Fujii are:
Vital-Fujii, D.G, Baptista, M.S. (2021). Progress in the photodynamic therapy treatment of Leishmaniasis. Brazilian Journal of Medical and Biological Research, 54, 1-11.
Gatti, F. M., Gomes, R.A., da Fonseca, A.L., Lima, E.J.C., Vital-Fujii, D.G., Taranto, A.G., Varotti, F.P., Trossini, G.H.G. (2020). Antiplasmodial activity of sulfonylhydrazones: in vitro and in silico approaches. Future medicinal chemistry, 13, 233-250.
Silva, E.J., Bezerra-Souza, A., Passero, L.F., Laurenti, M.D., Ferreira, G.M., Fujii, D.G.V., et al. (2018). Synthesis, leishmanicidal activity, structural descriptors and structure-activity relationship of quinoline derivatives. Future medicinal chemistry, 10, 2069-2085.
Leite, F.H.A., Froes, T.Q., da Silva, S.G., de Souza, E.I.M., Vital-Fuji,i D.G., Trossini, G.H.G., et al. (2017). An integrated approach towards the discovery of novel non-nucleoside Leishmania major pteridine reductase 1 inhibitors. European Journal of Medicinal Chemistry, 132, 322-332.
Vital, D.G., Damasceno, F.S., Rapado, L.N., Silber, A.M., Vilella, F.S., Ferreira, R.S., et al. (2017). Application of bioisosterism in design of the semicarbazone derivatives as cruzain inhibitors: a theoretical and experimental study. Journal of Biomolecular Structure and Dynamics, 35, 1244–1259.
Mello, J. F.R., Gomes, R.A., Vital-Fujii, D.G., Ferreira, G.M., Trossini, G.H.G. (2017). Fragment-based drug discovery as alternative strategy to the drug development for neglected diseases. Chemical Biology & Drug Design, 90, 1067-1078.
Pantaleao, S.Q., Fujii, D.G.V., Maltarollo, V.G., da C. Silva, D., Trossini, G.H.G., Weber, K.C., et al. (2017). The Role of QSAR and Virtual Screening Studies in Type 2 Diabetes Drug Discovery. Medicinal Chemistry, 13, 706-720.
Vital, D., Arribas, M., Trossini, G. (2014). Molecular Modeling and Docking Application to Evaluate Cruzain Inhibitory Activity by Chalcones and Hydrazides. Letters in Drug Design and Discovery, 11, 249-255.
Blau, L., Menegon, R.F., Trossini, G.H.G., Molino, J.V.D., Vital, D.G., Cicarelli, R.M.B., et al. (2013). Design, synthesis and biological evaluation of new aryl thiosemicarbazone as antichagasic candidates. European Journal of Medicinal Chemistry, 67, 142-151.
You can view some of Dr Drielli’s work below and links to her professional profile.
Orcid: https://orcid.org/0000-0001-9270-0466
Research Gate: https://www.researchgate.net/profile/Drielli-Gomes-Vital-Fujii
Scopus: https://www.scopus.com/authid/detail.uri?authorId=55829534000
Google Scholar: https://scholar.google.com/citations?user=F9U50AEAAAAJ&hl=pt-BR
Linkedin: linkedin.com/in/driellivital
Escavador: https://www.escavador.com/sobre/6101380/drielli-gomes-vital
CDIPD: https://cdipd.org/index.php/about-us/visiting-scientists
close
Reviewer bio
Dr Drielli Vital-Fujii, PhD, is a Pharmacist with expertise in Drug Design and Development, Enzymes, Molecular Modelling, and Photodynamic Therapy. She writes and reviews content on these topics.
Dr Drielli Vital-Fujii’s Highlights:
- Postdoctoral fellow at the Department of Biochemistry at the University of São Paulo, emphasizing therapy of neglected diseases using light.
- PhD in Pharmaceutical Sciences focusing on drug design and development at the Faculty of Pharmaceutical Sciences of the University of São Paulo.
- Six months as an international researcher at the Center for Discovery and Innovation in Parasitic Diseases (University of California San Diego)
- Master’s degree in Pharmaceutical Sciences focusing on drug design and development at the Faculty of Pharmaceutical Sciences of the University of São Paulo.
- Bachelor of Pharmacy at the University of Mogi das Cruzes – São Paulo / Brazil
Professional Experience:
2012 – 2018 Project manager at University of São Paulo – Pharmacy Department
Dr Drielli Vital-Fujii has worked with computational studies, synthesis, biological evaluation, design, and development of new inhibitor candidates for Chagas Disease and Leishmaniasis.
2017 – 2017 International research fellow at University of California San Diego Skaggs School of Pharmacy and Pharmaceutical Sciences – Center for Discovery and Innovation in Parasitic Diseases.
She used Virtual Screening (VS) and High-Throughput Screening (HTS) Integration in the Discovery of new drugs against neglected tropical diseases (NTDs).
2018 – 2019 Faculdades Oswaldo Cruz
Dr Drielli Vital-Fujii was a professor in the Faculty of Pharmacy, teaching the subjects of Pharmaceutical Chemistry and Drug Development.
2019 – 2021 Researcher in Biochemistry University of São Paulo – Biochemistry Department
She applied Photodynamic Therapy in Leishmaniasis Treatment, mentored undergraduate students in scientific activities, and wrote, executed, translated, and reported scientific projects with funding agencies.
2023-2023 UniPiaget – University Center.
Dr Drielli Vital-Fujii was a Biology, Nutrition, Physiotherapy, and Pharmacy professor.
Education:
2018 -2021 Postdoctoral at the Department of Biochemistry at the University of São Paulo
2013 -2018 PhD of Science: Drugs and Medicines at Department of Pharmacy at University of São Paulo
2012 -2013 M.Sc. of Sciences: Drugs and Medicines at the Department of Pharmacy at the University of São Paulo
2005-2008 Bachelor of Pharmacy at the University of Mogi das Cruzes
The leading publications of Dr Drielli Vital-Fujii are:
Vital-Fujii, D.G, Baptista, M.S. (2021). Progress in the photodynamic therapy treatment of Leishmaniasis. Brazilian Journal of Medical and Biological Research, 54, 1-11.
Gatti, F. M., Gomes, R.A., da Fonseca, A.L., Lima, E.J.C., Vital-Fujii, D.G., Taranto, A.G., Varotti, F.P., Trossini, G.H.G. (2020). Antiplasmodial activity of sulfonylhydrazones: in vitro and in silico approaches. Future medicinal chemistry, 13, 233-250.
Silva, E.J., Bezerra-Souza, A., Passero, L.F., Laurenti, M.D., Ferreira, G.M., Fujii, D.G.V., et al. (2018). Synthesis, leishmanicidal activity, structural descriptors and structure-activity relationship of quinoline derivatives. Future medicinal chemistry, 10, 2069-2085.
Leite, F.H.A., Froes, T.Q., da Silva, S.G., de Souza, E.I.M., Vital-Fuji,i D.G., Trossini, G.H.G., et al. (2017). An integrated approach towards the discovery of novel non-nucleoside Leishmania major pteridine reductase 1 inhibitors. European Journal of Medicinal Chemistry, 132, 322-332.
Vital, D.G., Damasceno, F.S., Rapado, L.N., Silber, A.M., Vilella, F.S., Ferreira, R.S., et al. (2017). Application of bioisosterism in design of the semicarbazone derivatives as cruzain inhibitors: a theoretical and experimental study. Journal of Biomolecular Structure and Dynamics, 35, 1244–1259.
Mello, J. F.R., Gomes, R.A., Vital-Fujii, D.G., Ferreira, G.M., Trossini, G.H.G. (2017). Fragment-based drug discovery as alternative strategy to the drug development for neglected diseases. Chemical Biology & Drug Design, 90, 1067-1078.
Pantaleao, S.Q., Fujii, D.G.V., Maltarollo, V.G., da C. Silva, D., Trossini, G.H.G., Weber, K.C., et al. (2017). The Role of QSAR and Virtual Screening Studies in Type 2 Diabetes Drug Discovery. Medicinal Chemistry, 13, 706-720.
Vital, D., Arribas, M., Trossini, G. (2014). Molecular Modeling and Docking Application to Evaluate Cruzain Inhibitory Activity by Chalcones and Hydrazides. Letters in Drug Design and Discovery, 11, 249-255.
Blau, L., Menegon, R.F., Trossini, G.H.G., Molino, J.V.D., Vital, D.G., Cicarelli, R.M.B., et al. (2013). Design, synthesis and biological evaluation of new aryl thiosemicarbazone as antichagasic candidates. European Journal of Medicinal Chemistry, 67, 142-151.
You can view some of Dr Drielli’s work below and links to her professional profile.
Orcid: https://orcid.org/0000-0001-9270-0466
Research Gate: https://www.researchgate.net/profile/Drielli-Gomes-Vital-Fujii
Scopus: https://www.scopus.com/authid/detail.uri?authorId=55829534000
Google Scholar: https://scholar.google.com/citations?user=F9U50AEAAAAJ&hl=pt-BR
Linkedin: linkedin.com/in/driellivital
Escavador: https://www.escavador.com/sobre/6101380/drielli-gomes-vital
CDIPD: https://cdipd.org/index.php/about-us/visiting-scientists
In this brief article, we will answer the question, “Does Zoloft expire?” and other questions, like What does the expiration date for drugs mean?; what are the dangers associated with using expired Zoloft?; What to do if you have taken expired Zoloft?
Does Zoloft expire?
Yes, Zoloft(also known as Lustral or Sertraline) does expire like every other medication. However, experts believe that it can remain effective for a long period of time, even after the drug has expired, but only if it is stored properly.
Improper storage conditions can accelerate the process of degradation much earlier than it should begin. The shelf life of Zoloft may become affected if the drug is dispensed in a pill bottle.
What does the expiration date for drugs mean?
The expiration date of drugs is an important indicator of their stability and effectiveness. It ensures that the drug will maintain its desired properties, including purity and potency, as long as it is stored properly. (1,2).
Drugs that require approval from regulatory agencies like the FDA undergo tests to demonstrate their stability and provide confidence that they will retain their intended characteristics throughout their shelf life (1).
What are the dangers associated with using expired Zoloft?
Using expired Zoloft can be dangerous because it can affect your brain chemistry. Specifically, it can increase the levels of serotonin, a chemical naturally found in the brain that helps regulate mood and emotions (3).
Altering the balance of serotonin can disrupt the normal functioning of the brain and impact mental stability. Therefore, it is important to avoid using expired Zoloft and consult with a healthcare professional for guidance on medication safety.
If your depression affects the quality of your life, you would not want to risk your mental health for an expired pill. If the drug has started to lose its potency, you will not be able to achieve your desired therapeutic goals and the antidepressant won’t make you feel well.
In fact, it can lead to disease progression and drug resistance. Zoloft is used for a number of symptoms associated with depression, anxiety, obsessive-compulsive disorder, overthinking, panic episodes, anger, anhedonia, rumination, depression comorbid with grief, social anxiety disorder, etc.
It can also be combined with other medications to manage depression comorbid with other conditions, like psychosis and paranoia. Zoloft may also help in chronic pain relief, but its use for this purpose is limited.
You have to make sure that you take it in the right possible way and that your drug is fully potent. No matter how many times you have read that Zoloft can remain effective for infinity, there is absolutely no way to support that claim.
There is no research data available regarding the safety and efficacy of expired antidepressants and no one can say for sure what potential health risks are associated with their use, not even the manufacturers. (4)
That’s the entire point of printing expiry dates on the packaging, as the manufacturers can’t guarantee the safety of their medications past the expiration dates (2,4).
Furthermore, you shouldn’t have expired Zoloft tablets. If your doctor prescribed this medication, you should have taken it every single day and you should have gone for a refill. Zoloft takes time to work and it should not be taken intermittently. Furthermore, expired SSRIs could be dangerous.
What to do if you have taken expired Zoloft?
If you have taken Zoloft that has expired, it’s important to note that we don’t have specific information about how the drug may change after its expiry date. However, using expired medications can be potentially harmful for several reasons.
Over time, the chemical composition of expired medicines can degrade, leading to reduced effectiveness or an increased risk of adverse effects (5). Therefore, it is generally recommended to avoid taking expired medications and to consult with a healthcare professional for proper guidance.
As said before, there is no guarantee that the medicine will be safe and effective after expiration. Do not take your medication if it is expired. It can harm your treatment! (5)
Also, expired drugs that have undergone chemical degradation can generate toxic substances in the body (5).
How should you store Zoloft?
To ensure the proper storage of Zoloft, as well as other medications, it is essential to follow the manufacturer’s guidelines. One important aspect is to avoid exposing the medication to significant fluctuations in temperature and humidity (6).
This means that storing Zoloft in places like the kitchen, bathroom, or bedroom may not be ideal as these areas are prone to temperature changes and humidity, which can negatively affect the stability of the medication (6).
To maintain the stability of Zoloft, it is recommended to store it in a location in your house that has consistent temperature and humidity levels and is protected from light and heat.
Some suitable storage options include a dresser drawer, a kitchen cabinet that is away from the stove or sink, a storage box, a shelf, or a closet. These locations provide a more controlled environment for the medication, helping to preserve its effectiveness (6,7).
What to do with expired Zoloft?
If you have expired Zoloft that you need to dispose of, there are safe ways to do so. One option is to utilize a drug take-back program. Many drugstores have drop-off boxes specifically designed for collecting expired medications.
You can simply deposit your expired Zoloft in one of these boxes, ensuring proper disposal.
Another option is to consult with local law enforcement officials who can provide guidance on the safe disposal of expired medications.
They may have specific procedures or recommendations in place to help you dispose of the medication in a way that is safe for you and the environment. (8)
Conclusion
In this brief article, we have answered the question, “Does Zoloft expire?” and other questions, like what are the dangers associated with using expired Zoloft and what to do if you have taken expired Zoloft.
Thanks for your feedback!
References
3.-
PubChem [Internet]. Bethesda (MD): National Library of Medicine (US), National Center for Biotechnology Information; 2004-. PubChem Compound Summary for CID 68617, Sertraline; [cited 2022 Oct. 17]. Available from: https://pubchem.ncbi.nlm.nih.gov/compound/Sertraline
4.-
Sharma S, Sharma AK, Moe HW, Khanapure A, Mohan P. A study to investigate the chemical potency, physical stability, and efficacy of analgesic agents over a period of two years post their expiry date. Med J Armed Forces India [Internet]. Elsevier Ltd; 2022;78(xxxx):S194–200. Available from: https://doi.org/10.1016/j.mjafi.2021.03.015
7.-
A.D.A.M. Medical Encyclopedia [Internet]. Johns Creek (GA): Ebix, Inc., A.D.A.M.; c1997-2020. Nail abnormalities; [updated 2019 Jul 31; reviewed 2019 Apr 16; cited 2023 Mai 31]; [about 4 p.]. Available from: https://medlineplus.gov/ency/article/003247.htm