Does Sertraline stop you from overthinking? (3+benefits)

In this article, we will discuss whether Sertraline stops you from overthinking. We will also discuss how overthinking is connected to depression and how Sertraline can help you with that. 

Does Sertraline stop you from overthinking?

Yes, Sertraline can stop you from overthinking. Anxiety, panic episodes, and overthinking are common symptoms of mental health conditions treated by Sertraline and this antidepressant can help manage these symptoms. 

However, the time taken by Sertraline to help you stop overthinking and alleviate overall depression symptoms can vary from person to person. 

Some people may take weeks to observe a noticeable change, while some may begin to feel different relatively earlier. It is important to discuss your symptoms with your doctor to receive the best possible treatment to manage them.

What does research suggest?

Research studies have indicated that Sertraline is a good choice of antidepressant for managing symptoms of depression, including overthinking, hopelessness, persistent sadness, and suicidal thoughts (1). 

Sertraline is a selective serotonin reuptake inhibitor that works by increasing serotonergic activity in the brain. Serotonin is an excitatory neurotransmitter and its deficiency is one of the main factors leading to depression (2). 

However, research indicates that Sertraline may not help you with these symptoms right away. One research study showed that Sertraline did not improve depression symptoms adequately after 6 weeks of treatment (3). 

The antidepressant can take up to 12 weeks for some people to notice a reduction in these symptoms.

What are the benefits of Sertraline for people who overthink?

As stated earlier, Sertraline can help people who overthink by managing depression. Some important benefits include (4):

  • Sertraline can help individuals to calm their racing thoughts and reduce excessive worrying. This leads to a more peaceful state of mind.
  • People on Sertraline often report reduced anxiety about what others may think of them. This can lead to greater self-confidence and decreased social anxiety.
  • This antidepressant can help individuals see the brighter side of life. They become more capable of focusing on positive aspects rather than dwelling on negatives.
  • With reduced anxiety and overthinking, individuals may find it easier to stay motivated and pursue their goals.
  • Sertraline can help people concentrate better and avoid getting stuck in a cycle of unproductive thoughts.

What to do if Sertraline fails to help your overthinking?

If Sertraline fails to help your overthinking after taking the antidepressant for 8-12 weeks, you should discuss this with your healthcare provider. Sertraline is generally a well-tolerated antidepressant, but it may work well for everyone. 

If Sertraline fails to help your symptoms, and you constantly find yourself depressed and overthinking despite taking the medications for several weeks, it indicates that Sertraline is not the right choice of medication for you. In such a case, you should seek medical advice. 

Do not try to change your dosage or frequency on your own. It is also important to make sure you do not stop taking Sertraline abruptly thinking it doesn’t work. 

It may not have helped your symptoms much, but your body won’t be able to accept sudden discontinuation without causing withdrawal symptoms. To prevent these symptoms, you have to gradually taper the antidepressant off. This should only be done under your doctor’s supervision. 


In this article, we have discussed whether Sertraline helps with overthinking. We have also discussed the possible mechanism through which Sertraline can alleviate depression symptoms and some benefits of this antidepressant on your thought processes.


  1. McRae AL, Brady KT. Review of sertraline and its clinical applications in psychiatric disorders. Expert Opin Pharmacother. 2001 May;2(5):883-92. doi: 10.1517/14656566.2.5.883. PMID: 11336629. 
  1. Singh HK, Saadabadi A. Sertraline. 2023 Feb 13. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 Jan–. PMID: 31613469. 
  1. Lewis G, Duffy L, Ades A, Amos R, Araya R, Brabyn S, Button KS, Churchill R, Derrick C, Dowrick C, Gilbody S, Fawsitt C, Hollingworth W, Jones V, Kendrick T, Kessler D, Kounali D, Khan N, Lanham P, Pervin J, Peters TJ, Riozzie D, Salaminios G, Thomas L, Welton NJ, Wiles N, Woodhouse R, Lewis G. The clinical effectiveness of sertraline in primary care and the role of depression severity and duration (PANDA): a pragmatic, double-blind, placebo-controlled randomised trial. Lancet Psychiatry. 2019 Nov;6(11):903-914. doi: 10.1016/S2215-0366(19)30366-9. Epub 2019 Sep 19. PMID: 31543474; PMCID: PMC7029306. 
  1. The Food and Drug Administration (FDA). HIGHLIGHTS OF PRESCRIBING INFORMATION. ZOLOFT (sertraline hydrochloride) tablets, for oral use. Available from: 

Was this helpful?

Thanks for your feedback!

Find a supportive therapist who can help with Depression.

Discover the convenience of BetterHelp, an online therapy platform connecting you with licensed and accredited therapists specialized in addressing issues such as depression, anxiety, relationships, and more. Complete the assessment and find your ideal therapist within just 48 hours.


AskYourPharm is user-supported. We may earn a commission if you sign up for BetterHelp’s services after clicking through from this site