Does Sertraline work like Xanax? (3+ differences)

In this article, we will answer the question, “Does Sertraline work like Xanax?”. We will compare two medications Sertraline and Xanax and explore there mechanism of action, therapeutic uses, side effects, withdrawal symptoms and what factors should be considered when choosing between the two.

Does Sertraline work like Xanax?

Sertraline (Zoloft) does not work like Xanax (Alprazolam). Both Setraline and Xanax are different medications, used to treat different conditions and have different ways of working in the body. However, the general use of both medicadtions is the same, i.e. in depressive and anxiety disorders.

Sertraline is a selective serotonin reuptake inhibitor (SSRI), approved by the FDA for the treatment of depressive disorders like major depressive disorder (MDD), obsessive-compulsive disorder (OCD), panic disorder (PD), posttraumatic stress disorder (PTSD), social anxiety disorder (SAD) and premenstrual dysphoric disorder (PMDD) (1).

Xanax on the other hand, does not act on serotonin and belongs to a class of medications known as benzodiazepines. It is approved by the FDA in the treatment of anxiety and panic disorders like generalised anxiety disorder (GAD) and panic disorder with or without agoraphobia (2).

While both the medications do treat anxiety disorders, they have different mechanisms of action and side effects. Keep in mind that medication response can vary from preson to person, so you should always consult a healthcare professional before taking any medication.

What are the differences between Sertraline and Xanax?

The differences between Sertraline and Xanax are as described below (3,4).

Characteristic Sertraline Xanax
Mechanism of action Sertraline inhibits sertonin reuptake in the brain, resulting in the increase in serotonin levels. High levels of serotonin regulte mood and personality, and improve depressive symptoms. Xanax is a benzodiazepine that binds to GABA-A receptors and increases the activity of the neurotransmitter, gamma aminobutyric acid (GABA). This decreases anxiety levels and causes sedation.
Therapeutic uses

Sertraline is used for

  • PTSD
  • MDD
  • OCD
  • Panic disorder
  • SAD
  • PMDD
  • Bulimia nervosa
  • Binge eating disorder
  • Body dysmorphic disorder
  • GAD
  • Premature ejaculation

Xanax is used for

  • GAD
  • SAD
  • Panic disorder
  • Anxiety-related insomnia
  • Adjunctive treatment for depression-related anxiety
  • Acute alcohol withdrawal symptoms
  • Severe stress
  • Situational anxiety
Onset of action

Sertraline has a slow onset of action. The effects of Sertraline take a few weeks to reach a noticeable potential.

Xanax has a more rapid onset of action. It can provide quick relief and is a more suitable option for short-term management of anxiety.

Side effects
  • Hypotension
  • Lightheadedness
  • Fatigue
  • Nausea
  • Confusion
  • Difficulty concentrating
  • Impaired coordination
  • Blurred vision
  • Red eyes
  • Memory problems
  • Headache
  • Dry mouth
  • Dizziness
  • Drowsiness
  • Constipation
  • Changes in appetite
  • Weight gain or weight loss
  • Hypomania
  • Slurred speech
Withdrawal symptoms

Withdrawal symptoms of Sertraline include

  • Nausea
  • Sweating
  • Agitation
  • Dysphoric mood
  • Irritability
  • Dizziness
  • Shock-like sensations
  • Tremors
  • Anxiety
  • Confusion
  • Tinnitus
  • Hypomania
  • Seizures

Xanax can cause a more severe withdrawal syndrome than SSRIs. Symptoms of Xanax withdrawal include

  • Insomnia
  • Irritability
  • Anxiety
  • Restlessness
  • Sweating
  • Heightened sensory perception
  • Tremors
  • Muscle pain
  • Seizures
  • Impaired concentration
  • Diarrhoea
  • Blurred vision
  • Appetite decrease
  • Muscle cramps
  • Weight loss
Addiction potential

Sertraline is not addictive in nature and does not have a high rate of dependence and abuse.

Xanax has a very high addictive potential. It may be habit-forming and may cause physical and psychological dependence.

How to choose between taking Sertraline or Xanax?

While making the choice between Sertraline and Xanax, various factors play a role. This decision is made by a healthcare professional after all the factors have been taken into consideration. The factors that should be kept in mind are patient characteristics, nature of illness, symptoms, medical history of individual and underlying health conditions.

Sometimes the intensity of symptoms may influence the choice of medication. Xanax has a rapid onset of action, so if an individual requires immediate relief from the symptoms, Xanax may be chosen. It also may be given as a combination with Sertraline.

However, Xanax has a very high addiction potential and should be used with caution in individuals with a history of substance abuse. Potential drug interactions with any pre-prescribed medications should also be considered.

Keep in mind that the decision between Sertraline and Xanax should be made in consultation with your healthcare provider. Your doctor will assess the potential risks and benefits of these medications and prescribe you the one that will benefit you the most.

Understanding the key differences between Sertraline and Xanax

To the best of my knowledge, Sertraline and Xanax are two different medications with different mechanisms of action and therapeutic uses. Sertraline is an SSRI prescribed for various depressive illnesses, whereas, Xanax is a benzodiazepine used in anxiety disorders.

Both Sertraline and Xanax can be used for anxiety and may also be co-administered for maximum benefits. However, both medications have different mechanisms, therapeutic uses, side effect profiles and withdrawal symptoms. It is advised to consult a healthcare provider to determine the best option for your condition.

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References

1.-

The Food and Drug Administration (FDA). HIGHLIGHTS OF PRESCRIBING INFORMATION. ZOLOFT® (sertraline hydrochloride) tablets, for oral use. Available from: https://www.accessdata.fda.gov/drugsatfda_docs/label/2016/019839s74s86s87_20990s35s44s45lbl.pdf

2.-

The Food and Drug Administration (FDA). HIGHLIGHTS OF PRESCRIBING INFORMATION. XANAX® (alprazolam) tablets, for oral use. Available from: https://www.accessdata.fda.gov/drugsatfda_docs/label/2021/018276s055lbl.pdf

3.-

Singh HK, Saadabadi A. Sertraline. [Updated 2023 Feb 13]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK547689/

4.-

George TT, Tripp J. Alprazolam. [Updated 2023 Apr 24]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK538165/

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