Does Wellbutrin make Vyvanse less effective? (3+ facts)

In this article, we will discuss the effect of Wellbutrin on the efficacy of Vyvanse. What are the side effects of combining Wellbutrin and Vyvanse? We will also talk about the ways you can minimise the side effects.

Does Wellbutrin make Vyvanse less effective?

Yes, Wellbutrin can make Vyvanse less effective; by raising the levels of Vyvanse it can lead to side effects and decrease its effectiveness.

Wellbutrin (Bupropion) is an antidepressant used to treat depression. Vyvanse (Lisdexamfetamine) treats attention-deficit/hyperactivity (ADHD) in children above six years of age and adults. 

In clinical practice, a combination of antidepressants and CNS stimulants are used to treat depression in individuals with ADHD. (1)

What are the potential drug interactions between Wellbutrin and Vyvanse?

Taking Wellbutrin and Vyvanse together can increase the risk of side effects caused by individual drugs, which can be harmful. 


Bupropion is associated with an increased risk of seizures. The appearance of seizures is strongly associated with Bupropion dose. Taking drugs like Vyvanse along with Bupropion can increase the risk of seizures. (5)

You are at a higher risk of experiencing seizures if you have a seizure disorder history, are an elderly patient, or are undergoing alcohol withdrawal syndrome. Your physician may alter your medication and offer alternatives to prevent potential side effects.

Cardiovascular events:

An increase in the level of Vyvanse can affect cardiovascular functioning, and you may experience palpitation, increased heart rate and increased blood pressure. In some cases, chronic Vyvanse use causes cardiomyopathy.

You may also have a risk of getting oedema, abnormal ECG, shortness of breath and chest pain. If you experience any of these side effects, approach your healthcare provider. 

Vision disturbance: 

Amphetamines like Vyvanse and Bupropion cause vision disturbance. It is an infrequent side effect. However, side effects of drugs can vary from person to person. 

The visual disturbance caused by these medications subsides within a few days. Make sure you consult your healthcare physician if you have any visual changes.

What are the factors to consider while using Wellbutrin with Vyvanse? 

By combining Wellbutrin and Vyvanse, you can safely manage your symptoms. Since Wellbutrin and Vyvanse increase dopamine levels in the brain, this combination can be used to treat ADHD. However, it’s important to keep in mind that there are specific measures to follow.

  • Cardiovascular disease: If you have hypertension or tachycardia, it is better to avoid this combination as it can increase the risk due to its synergistic effect.
  • Seizure disorder: This combination will increase the risk of seizures in patients with a history of seizure disorder

How can you minimise the side effects of Wellbutrin and Vyvanse? 

Minimising the side effects caused by co-administration of Wellbutrin and Vyvanse involves working with your healthcare provider to make proper adjustments to your treatment and lifestyle.

  • Know about your medication: If you are taking Wellbutrin and Vyvanse, it’s important to be aware of potential side effects.
  • Foods to avoid: Alcohol increases the risk of side effects like seizures, hallucinations, delusions, anxiety and behavioural changes when taken with Bupropion, and an increased risk of cardiovascular side effects with Vyvanse   
  • Regular monitoring: Attend follow-up appointments and monitor for unwanted symptoms regularly.
  • Food and Hydration: If Bupropion and Vyvanse cause nausea or vomiting, they should be taken with food.
  • Caffeine: Avoid caffeine-containing products since they exacerbate side effects like jitteriness and increase heart rate.
  • Right dose at the right time: Take your medication as prescribed by your physician. Do not stop taking your medication without informing your physician since it may cause withdrawal symptoms and worsen your condition. 


This article discusses the potential interaction and side effects of Wellbutrin when used alongside Vyvanse. If you experience any side effects that may pose a risk to your health, consult your healthcare provider for appropriate intervention.

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Turgay A, Ansari R. Major Depression with ADHD: In Children and Adolescents. Psychiatry (Edgmont). 2006 Apr;3(4):20-32. PMID: 21103168; PMCID: PMC2990565. Available from:


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Fava M, Rush AJ, Thase ME, Clayton A, Stahl SM, Pradko JF, Johnston JA. 15 years of clinical experience with bupropion HCl: from bupropion to bupropion SR to bupropion XL. Primary care companion to the Journal of clinical psychiatry. 2005;7(3):106. Available from:


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