Does Venlafaxine cause joint and muscle pain? 

Does Venlafaxine cause joint and muscle pain? 

Venlafaxine does not generally cause joint and muscle pain, and they are not frequently reported. However, people are different and they respond differently to medications. 

Some may feel body pain during the early course of their treatment, especially people who are new to Venlafaxine or antidepressants in general. However, Venlafaxine does not necessarily affect your muscles or bones. 

In some cases, muscle pain paired with other side effects like confusion, weakness, and constant headaches could be a sign of sodium deficiency – a condition known as Hyponatremia. Venlafaxine can cause sodium deficiency, but it is also a rare side effect. 

What does research suggest?

There is limited research on the harmful effects of Venlafaxine on muscles and bones. However, some cases of body pain are reported. Researchers have indicated that Venlafaxine can actually help with pain, and it has shown muscle-relaxing properties in some people (1). 

However, it can also trigger body pain, especially in people who are new to this medication or antidepressants in general. 

Overall, clinical findings don’t indicate serious muscle or bone damage caused by Venlafaxine and some people who have experienced this may have some other factors contributing to this side effect.

What to do if Venlafaxine causes joint and muscle pain? 

It’s best to reach out to your healthcare provider if you’re experiencing muscle and joint pain. Your doctor may ask for sodium screening to ensure that you’re not deficient. 

If you’re a new user, your side effects will most probably subside on their own within a few weeks as your body adjusts to the medication. However, you can try OTC painkillers like Acetaminophen to help with your pain. 

You can also apply a warm compress and stretch your muscles to help them breathe and release the excess tension in them. Most people adjust to these meds within 2-4 weeks, but some may take longer. 

Just keep monitoring your side effects to know for sure how Venlafaxine makes you feel and discuss them with your doctor. 

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Grothe DR, Scheckner B, Albano D. Treatment of pain syndromes with venlafaxine. Pharmacotherapy. 2004 May;24(5):621-9. doi: 10.1592/phco.24.6.621.34748. PMID: 15162896. Available from:

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