How soon does Effexor start to work? 

How soon does Effexor start to work? 

Effexor starts to work in about 4-6 weeks, but you may feel less depressed in 2-3 weeks. The time taken by Effexor to start working may vary from person to person and depend on the overall severity of your mental health condition. 

If we talk about mild depression, you will definitely feel better in a few weeks, as compared to a person battling major depressive disorder (MDD) who needs weeks and weeks of treatment for noticeable antidepressant effects. 

Effexor and other depressants are not fast-acting meds which can provide you with instant relief. Taking antidepressants is a long-term commitment. 

Effexor gradually increases the number of excitatory neurotransmitters in your brain – serotonin and norepinephrine – a change to which your body takes time to adjust. 

You may feel unwell during the first 2 weeks and experience side effects like nausea, dizziness, tiredness, drowsiness, or insomnia – but these side effects go away once your body fully accepts the medication. This could get nerve-racking for some people, but it does get better with time.

What if Effexor does not work well? 

Effexor may not work well in some individuals, although it is generally a well-tolerated antidepressant – but don’t worry! There are plenty of other antidepressants to replace Effexor if it doesn’t provide adequate relief for your symptoms. 

Determining the best antidepressant is a trial and error process, and it could take multiple attempts to find ‘The one‘. So don’t worry if Effexor doesn’t work well for you. 

Your doctor will switch you to another antidepressant in the best possible way to avoid withdrawal symptoms and manage your depression properly. Make sure you don’t make such changes without your doctor’s approval. 

Final words

To sum up, Effexor can take a few weeks to start working. Although it is generally a well-tolerated antidepressant, it may not work well for every other individual. Some people may discontinue taking Effexor even before it kicks in because of the early side effects. 

This is not uncommon for doctors to switch antidepressants because of unbearable side effects. If for some reason, Effexor fails to help your mental health condition, there are plenty of antidepressants that can replace it. 

Just make sure you discuss your side effects and overall progress with your doctor. It is not wise to judge an antidepressant before giving it enough time to work. If it doesn’t make you feel better even after weeks and weeks of your treatment, your doctor will safely switch you to another one.

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National Library of Medicine (US). Venlafaxine. Bethesda (MD): U.S. National Library of Medicine; 2021 Mar 15 [updated 2021 Mar 15; cited 2022 Feb 21]. Available from:

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