Does Trintellix help memory loss? (+7 medications)

 In this article, we will discuss the role of Trintellix in improving memory and cognitive function. We will also explore research studies that indicate the use of Trintellix in patients with impaired cognitive function, as well as other medications that may help improve memory if Trintellix proves ineffective.

Does Trintellix help memory loss?

Yes, Trintellix does help with short-term memory loss. While its primary indication is for the treatment of depression, some studies suggest that this medication may have cognitive-enhancing effects (1).

Research indicates that Trintellix may positively impact cognitive function, including aspects of memory and executive function, in some individuals with depression. However, it’s important to note that the effects on memory and cognition can vary from person to person.

If you are experiencing memory issues or cognitive difficulties, it’s crucial to discuss your concerns with a healthcare professional. They can provide a comprehensive evaluation of your symptoms and determine the most appropriate course of action based on your specific situation.

What does research suggest?

According to research, Trintellix is considered an effective medication for managing cognitive function in patients with underlying depression. In a recent study, the use of Trintellix at a dosage of 20mg daily for the management of dementia in patients with underlying depression showed that after 3 months of treatment, more than 50% of the patients reported improved cognitive function (2).

Another study demonstrated that Trintellix improved cognitive function in around 90% of the patients after 6 months of treatment at a dosage of 10 mg daily (3).

What to do if Trintillex fails to improve memory?

If you are prescribed Trintellix to manage your cognitive function and notice that it is not improving even after a few weeks of treatment, it’s advisable to consult with your healthcare provider.

They can assess your symptoms and determine the reasons behind the ineffectiveness of Trintellix. Sometimes, modifying the treatment plan, such as adjusting the dosage, might be beneficial for those who don’t respond well to the initial doses.

However, in some cases, if your memory issues are related to an underlying mental disorder such as Alzheimer’s, your healthcare provider may recommend switching to another medication that is more suitable for your condition, as Trintellix is not a primary choice for memory improvement in such patients.

What other medications can help memory loss?

Several medications are prescribed to help improve memory, depending on the individual’s condition. It’s important to note that the effectiveness of these medications can vary depending on the underlying cause of cognitive issues and individual responses (4).  

Cholinesterase inhibitors



NMDA receptor antagonist  Memantine 






What are the management tips for addressing impaired memory?

Managing memory loss can involve a combination of lifestyle changes, cognitive exercises, and healthcare strategies. Here are management tips to help manage memory loss or cognitive impairment:

  • Include foods rich in omega-3 fatty acids, antioxidants, and vitamins in your diet.
  • Stay socially active to stimulate your mind and reduce feelings of isolation.
  • Ensure you get enough quality sleep each night.
  • Engage in mentally challenging activities like puzzles or chess.
  • Regular reading can stimulate the brain and enhance cognitive function.
  • Play memory-enhancing games to improve cognitive skills.
  • Use memory aids like sticky notes or digital reminders.
  • Utilize digital calendars for reminders and scheduling.

In my experience

In my experience, Trintellix is commonly prescribed in clinical settings when addressing memory impairment in patients with an underlying condition of depression or anxiety. However, the choice of specific medications aimed at improving cognitive function is carefully tailored to the individual patient’s overall condition and the specific cause of their memory impairment.

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Koesters M, Ostuzzi G, Guaiana G, Breilmann J, Barbui C. Vortioxetine for depression in adults. Cochrane Database Syst Rev. 2017 Jul 5;7(7):CD011520. doi: 10.1002/14651858.CD011520.pub2. PMID: 28677828; PMCID: PMC6483322.


Michael Cronquist Christensen, Simon Nitschky Schmidt, Iria Grande, Effectiveness of vortioxetine in patients with major depressive disorder and early-stage dementia: The MEMORY study, Journal of Affective Disorders, Volume 338, 2023, Pages 423-431, ISSN 0165-0327,


Tan SN, Tan C. Vortioxetine improves cognition in mild cognitive impairment. Int Clin Psychopharmacol. 2021 Nov 1;36(6):279-287. doi: 10.1097/YIC.0000000000000376. PMID: 34282748; PMCID: PMC8483775.


Do D, Schnittker J. Utilization of Medications With Cognitive Impairment Side Effects and the Implications for Older Adults’ Cognitive Function. J Aging Health. 2020 Oct;32(9):1165-1177. doi: 10.1177/0898264319895842. Epub 2020 Jan 6. PMID: 31904296; PMCID: PMC8218591.

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