Can Trintellix help fibromyalgia? (+5 treatment options)

 In this article, we will explore the potential role of Trintellix in managing fibromyalgia. We will discuss research studies suggesting its impact on the symptoms associated with fibromyalgia and explore alternative options if Trintellix proves ineffective in some individuals. 

Can Trintellix help fibromyalgia?

Trintellix may help with fibromyalgia. It has shown some efficacy in managing fibromyalgia, although it is not FDA-approved for this specific use and is not considered a first-line treatment for fibromyalgia.

Trintellix is primarily an antidepressant medication used in the management of depression and anxiety, and its application in fibromyalgia is relatively uncommon. Nevertheless, certain research studies suggest its potential for alleviating the pain associated with fibromyalgia in some patients (1).

Commonly associated side effects of Trintellix include nausea, vomiting, dry mouth, insomnia, and dizziness (1).

What does research suggest?

The use of Trintellix in fibromyalgia is not firmly established according to current research, and further studies are needed to ensure its safety and efficacy in the management of fibromyalgia (3).

In a research study, Trintellix was combined with ropinirole to assess the potential of these drugs in the management of fibromyalgia. The results indicated effectiveness in reducing symptoms associated with fibromyalgia, including the alleviation of pain (2).

However, it’s important to note that additional research is required to fully understand the benefits and risks of Trintellix in the treatment of fibromyalgia.

What to do if Trintellix fails to manage fibromyalgia?

Trintellix is not commonly employed in the management of fibromyalgia. However, if your healthcare provider prescribes this medication for managing fibromyalgia in the presence of depression or any other mental disorders, you should take it as prescribed.

It’s important to note that the treatment with Trintellix may take a few weeks to start improving your symptoms, so patience is advised during this period. If you feel that your symptoms are not improving even after 2 to 3 weeks of treatment, consult your healthcare provider.

They will assess your condition and determine the cause of treatment failure. Your healthcare provider may adjust the dosage to achieve a therapeutic response, considering the balance between effectiveness and potential side effects.

In some cases, alternative medications may be recommended for the management of pain associated with fibromyalgia, depending on individual responses and side effect profiles. The decision to discontinue Trintellix should only be made under the guidance of your healthcare provider to minimize unwanted side effects

Which medications can be used to treat fibromyalgia?

There is no specific medication that can cure fibromyalgia. However, there are medications commonly prescribed to help manage symptoms associated with fibromyalgia such as:

Class Medications
Antidepressants Duloxetine, Milnacipran
Anticonvulsants Pregabalin
Muscle Relaxants Cyclobenzaprine
NSAIDs Ibuprofen, Naproxen
Benzodiazepines Clonazepam

It’s important to note that treatment plans may vary based on individual symptoms, and the effectiveness of medications can differ from person to person.

What are the management tips for fibromyalgia?

In addition to medication, your healthcare provider may recommend various non-pharmacological management strategies to enhance the overall management of fibromyalgia. These strategies may contribute to improved well-being and may include the following:

Dietary modifications: Adopting a healthy diet is considered a crucial aspect of managing fibromyalgia. Incorporating nutrient-rich foods and lean proteins can support overall health.

Sleep and stress management: Practices such as mindfulness meditation and an improved and consistent sleep schedule are essential for individuals with fibromyalgia, as the condition often disrupts sleep quality. Alongside any prescribed medications, practicing good sleep hygiene habits is crucial.

Physical activities: Regular physical exercise plays an important role in fibromyalgia management. Engaging in low-impact exercises, such as walking or cycling, can contribute to pain relief and improved overall function. Your healthcare provider may recommend a personalized exercise plan tailored to your individual needs and capabilities.

 In my opinion, the use of Trintellix in managing fibromyalgia is not common in clinical settings, as there are other medications that are more effective in symptomatically managing fibromyalgia. However, your healthcare provider may prescribe you this medication based on your individual conditions.

But you should never take this medication on your own for managing fibromyalgia or any other condition, as it may lead to unwanted and serious consequences

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Koesters M, Ostuzzi G, Guaiana G, Breilmann J, Barbui C. Vortioxetine for depression in adults. Cochrane Database Syst Rev. 2017 Jul 5;7(7):CD011520. doi: 10.1002/14651858.CD011520.pub2. PMID: 28677828; PMCID: PMC6483322.


Sałat K, Furgała-Wojas A. Serotonergic Neurotransmission System Modulator, Vortioxetine, and Dopaminergic D2/D3 Receptor Agonist, Ropinirole, Attenuate Fibromyalgia-Like Symptoms in Mice. Molecules. 2021 Apr 20;26(8):2398. doi: 10.3390/molecules26082398. PMID: 33924258; PMCID: PMC8074757.


Adamo D, Calabria E, Coppola N, Pecoraro G, Mignogna MD. Vortioxetine as a new frontier in the treatment of chronic neuropathic pain: a review and update. Ther Adv Psychopharmacol. 2021 Sep 3;11:20451253211034320. doi: 10.1177/20451253211034320. PMID: 34497709; PMCID: PMC8419528. a

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