Does Trazodone lower blood pressure? (+3 reasons)

In this article, we will discuss whether Trazodone lowers blood pressure. We will also discuss some research studies and what one should do if this side effect occurs.

Does Trazodone lower blood pressure?

Yes, Trazodone can lower the blood pressure. It is one of the listed side effects. However, the incidence is low. Patients taking Trazodone can experience an increased risk of a slow heart rate or blood pressure.

Trazodone is an antidepressant that increases serotonin levels in the brain, leading to a calming effect (1). It is not commonly associated with this side effect and the effects at standard therapeutic doses may be quite insignificant to even notice. 

If you experience a decrease in blood pressure or any other side effect while taking Trazodone, reach out to your healthcare provider. They can assess your specific condition and make adjustments accordingly.

What is the incidence of low blood pressure caused by Trazodone?

The incidence of low blood pressure caused specifically by Trazodone can vary from person to person. While Trazodone may have a mild and temporary effect of lowering blood pressure in some individuals, it is not common for it to cause a significant drop in blood pressure.

Notice the symptoms you feel after your dose intake of Trazodone. If you feel any of the following symptoms then it is Trazodone blood pressure lowering effect. These symptoms include:

  • Blurred or decreased vision
  • Fatigue
  • Dizziness
  • Trouble concentrating
  • Nausea
  • Vomiting
  • Fainting

What does research suggest?

There is limited research on the harmful effects of Trazodone on your blood pressure. Several studies have indicated that Trazodone is not a cardiotoxic antidepressant. It does not worsen the symptoms of a cardiac condition and can be used safely in people with heart disease (2).

One study indicated that eight people took Trazodone 150mg to see how it affected their hearts. Trazodone made the time the left ventricle squeezes longer, but it made the time before the squeeze shorter and changed the ratio between these times (3).

Also, after 90 minutes, it lowered the heart rate and the pressure when the heart contracts and relaxes went down (3).

Researchers have also indicated that people respond differently to medications and they experience different types of side effects. According to some research studies, some people may experience elevated blood pressure during an anxiety attack.

What favours experiencing lower blood pressure due to Trazodone?

Several reasons favour a decrease in blood pressure due to Trazodone. These include:

  • Low fluid intake in the body leads to a decrease in the total volume of blood. This leads to a decrease in blood pressure. Try to be always hydrated.
  • Resting in bed for long periods.
  • Patients with a history of low blood pressure in their family can experience lower blood pressure with Trazodone.
  • During pregnancy, blood pressure can be lowered.
  • Internal bleeding, endocrine disorders, diabetes and liver disease can lead to a decrease in blood pressure while using Trazodone.
  • Patients allergic to Trazodone can suffer severe hypotension as a response to allergic reactions.
  • Cardiovascular problems with Trazodone cause a drop in blood pressure.

What to do if Trazodone lowers your blood pressure?

If Trazodone is affecting your blood pressure, talk to your healthcare provider. Your doctor will determine if it is safe for you to continue using this antidepressant and if there is anything that can prevent your blood pressure from going down.

Your doctor may decrease your dose a little bit to help you adjust better to Trazodone. This antidepressant generally makes you feel unwell. However, most of the side effects are expected to go away once your body adjusts.

If the drug continues to affect your heart rate and blood pressure, your doctor will most likely switch you to another antidepressant. If the antidepressant needs to be stopped, your doctor will suggest the best possible way to do so.

Always remember never to make any changes to your treatment plan on your own as it can horrible symptoms further worsening your condition.

In my view, Trazodone can cause a decrease in blood pressure. This is a rare side effect that appears after long-term therapy periods. In my opinion, seek emergency medical care if you experience any unusual feelings, especially if they persist for some time. Any suicidal thoughts or behavioural changes need emergent medical care.


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