Does trazodone contain melatonin? (7+ precautions)

In this article, we will discuss whether trazodone contains melatonin. Furthermore, we will talk about the potential link between trazodone and melatonin, dosage recommendations, associated risks with combination treatment, and how to ensure safe and effective use of trazodone and melatonin. 

Does trazodone contain melatonin?

No, trazodone does not contain melatonin. Trazodone may induce sleep in patients using it as an antidepressant and melatonin, which is a hormone that regulates the sleep patterns in the human body. Melatonin is present naturally in the human body and also available as a supplement.

Some patients may think that trazodone might have melatonin in it, but this is not the case. Trazodone is an antidepressant that is FDA-approved to treat depression. Trazodone belongs to a class of drugs known as serotonin modulators. Trazodone inhibits serotonin reuptake in the synaptic regions of the brain (1). 

Melatonin, on the other hand, is a naturally occurring hormone present in the human body for regulating the sleep-wake cycle and it is more active at night compared to daytime. Melatonin supplements may also help people to resolve sleep issues (2). 

Is there any link between trazodone and melatonin?

According to a research study, patients with Parkinson’s disease who had sleep disorders were examined after giving trazodone and melatonin for 4 weeks. The results of this clinical study suggested that trazodone and melatonin supplements, both help induce sleep (3). 

In another research study, hospitalised patients were examined for their sleep issues during their stay at the hospital. Their doctors gave trazodone and melatonin to them and their sleep problems got better. Trazodone and melatonin both have almost similar efficacy in improving sleep quality (4). 

What are the dosages of trazodone and melatonin?

Trazodone dosage for insomnia ranges from 50mg to 100mg either as divided doses taken twice a day, or extended-release tablets taken once a day at nighttime. Trazodone 100mg has been found as most effective for treating insomnia (1). 

On the other hand, melatonin supplements can be taken in the dose of 0.1mg to 10mg depending on the person’s specific needs. Melatonin supplements are available in different dosage forms such as tablets both immediate-release or extended-release, oral solutions, suppositories, and patches. Melatonin can be used for 6 months in adults and 3 months in children (5,6).  

What are the risks of trazodone and melatonin combination?

The risks associated with the combination of trazodone and melatonin are increased sedation, drowsiness, difficulty concentrating, and daytime sleepiness. Do not take any drug combination without consulting your healthcare provider. 

Your healthcare provider will make you aware of the safe use of trazodone and melatonin combination. If you are taking this combination treatment, you should avoid driving and doing tasks that require concentration (6). 

How to ensure the safe use of trazodone and melatonin?

To ensure the safe use of trazodone and melatonin, you should follow the below guidelines:

  • Do not take trazodone or melatonin supplements if you are allergic to it. 
  • Please inform your healthcare provider if you are taking any other medicines or supplements. 
  • Please make sure your doctor is aware of your family or other medical health problems. 
  • Both trazodone and melatonin may make you sleepy, therefore avoid driving or any other tasks that might get affected due to sedation. 
  • You should avoid consuming alcohol as it may worsen the side effects of trazodone. 
  • Always take trazodone or melatonin supplements as prescribed by your healthcare provider. 
  • Do not change the time or dose of trazodone or melatonin on your own. 
  • If you want to discontinue trazodone, gradual tapering off is recommended, as sudden discontinuation may result in withdrawal effects (6). 

From my perspective, trazodone does not contain melatonin. Trazodone is an antidepressant that is FDA-approved to treat major depressive disorder and can also be used to treat insomnia. However, melatonin on the other hand is a hormone present in the human body that regulates body’s sleep patterns.  

Melatonin is also available in supplements and can be helpful to induce sleep. If you are using a combination of trazodone and melatonin after being prescribed by your doctor, you must be aware of its increased sedative effects. Always consult your healthcare provider before taking drugs in combination. 

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Pévet P. Melatonin. Dialogues Clin Neurosci. 2002 Mar;4(1):57-72. doi: 10.31887/DCNS.2002.4.1/ppevet. PMID: 22034091; PMCID: PMC3181670. Available from:


Hadi F, Agah E, Tavanbakhsh S, Mirsepassi Z, Mousavi SV, Talachi N, Tafakhori A, Aghamollaii V. Safety and efficacy of melatonin, clonazepam, and trazodone in patients with Parkinson’s disease and sleep disorders: a randomized, double-blind trial. Neurol Sci. 2022 Oct;43(10):6141-6148. doi: 10.1007/s10072-022-06188-4. Epub 2022 Jun 6. PMID: 35660990. Available from:


Letsinger E, Sickley R, Saum L. Melatonin Versus Trazodone for the Treatment of New Onset Insomnia in Hospitalized Adult Patients. Hosp Pharm. 2023 Apr;58(2):165-170. doi: 10.1177/00185787221123213. Epub 2022 Sep 8. PMID: 36890954; PMCID: PMC9986572. Available from:


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Trazodone-MedlinePlus [Internet]. Bethesda (MD): National Library of Medicine (US); [Last Revised – 01/15/2022]. Available from: 

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