Can you take Trazodone and Melatonin together?
By
Dr Drielli Vital-Fujii (PhD)
Author bio
Dr Drielli Vital-Fujii, PhD, is a Pharmacist with expertise in Drug Design and Development, Enzymes, Molecular Modelling, and Photodynamic Therapy. She writes and reviews content on these topics.
Dr Drielli Vital-Fujii’s Highlights:
- Postdoctoral fellow at the Department of Biochemistry at the University of São Paulo, emphasizing therapy of neglected diseases using light.
- PhD in Pharmaceutical Sciences focusing on drug design and development at the Faculty of Pharmaceutical Sciences of the University of São Paulo.
- Six months as an international researcher at the Center for Discovery and Innovation in Parasitic Diseases (University of California San Diego)
- Master’s degree in Pharmaceutical Sciences focusing on drug design and development at the Faculty of Pharmaceutical Sciences of the University of São Paulo.
- Bachelor of Pharmacy at the University of Mogi das Cruzes – São Paulo / Brazil
Professional Experience:
2012 – 2018 Project manager at University of São Paulo – Pharmacy Department
Dr Drielli Vital-Fujii has worked with computational studies, synthesis, biological evaluation, design, and development of new inhibitor candidates for Chagas Disease and Leishmaniasis.
2017 – 2017 International research fellow at University of California San Diego Skaggs School of Pharmacy and Pharmaceutical Sciences – Center for Discovery and Innovation in Parasitic Diseases.
She used Virtual Screening (VS) and High-Throughput Screening (HTS) Integration in the Discovery of new drugs against neglected tropical diseases (NTDs).
2018 – 2019 Faculdades Oswaldo Cruz
Dr Drielli Vital-Fujii was a professor in the Faculty of Pharmacy, teaching the subjects of Pharmaceutical Chemistry and Drug Development.
2019 – 2021 Researcher in Biochemistry University of São Paulo – Biochemistry Department
She applied Photodynamic Therapy in Leishmaniasis Treatment, mentored undergraduate students in scientific activities, and wrote, executed, translated, and reported scientific projects with funding agencies.
2023-2023 UniPiaget – University Center.
Dr Drielli Vital-Fujii was a Biology, Nutrition, Physiotherapy, and Pharmacy professor.
Education:
2018 -2021 Postdoctoral at the Department of Biochemistry at the University of São Paulo
2013 -2018 PhD of Science: Drugs and Medicines at Department of Pharmacy at University of São Paulo
2012 -2013 M.Sc. of Sciences: Drugs and Medicines at the Department of Pharmacy at the University of São Paulo
2005-2008 Bachelor of Pharmacy at the University of Mogi das Cruzes
The leading publications of Dr Drielli Vital-Fujii are:
Vital-Fujii, D.G, Baptista, M.S. (2021). Progress in the photodynamic therapy treatment of Leishmaniasis. Brazilian Journal of Medical and Biological Research, 54, 1-11.
Gatti, F. M., Gomes, R.A., da Fonseca, A.L., Lima, E.J.C., Vital-Fujii, D.G., Taranto, A.G., Varotti, F.P., Trossini, G.H.G. (2020). Antiplasmodial activity of sulfonylhydrazones: in vitro and in silico approaches. Future medicinal chemistry, 13, 233-250.
Silva, E.J., Bezerra-Souza, A., Passero, L.F., Laurenti, M.D., Ferreira, G.M., Fujii, D.G.V., et al. (2018). Synthesis, leishmanicidal activity, structural descriptors and structure-activity relationship of quinoline derivatives. Future medicinal chemistry, 10, 2069-2085.
Leite, F.H.A., Froes, T.Q., da Silva, S.G., de Souza, E.I.M., Vital-Fuji,i D.G., Trossini, G.H.G., et al. (2017). An integrated approach towards the discovery of novel non-nucleoside Leishmania major pteridine reductase 1 inhibitors. European Journal of Medicinal Chemistry, 132, 322-332.
Vital, D.G., Damasceno, F.S., Rapado, L.N., Silber, A.M., Vilella, F.S., Ferreira, R.S., et al. (2017). Application of bioisosterism in design of the semicarbazone derivatives as cruzain inhibitors: a theoretical and experimental study. Journal of Biomolecular Structure and Dynamics, 35, 1244–1259.
Mello, J. F.R., Gomes, R.A., Vital-Fujii, D.G., Ferreira, G.M., Trossini, G.H.G. (2017). Fragment-based drug discovery as alternative strategy to the drug development for neglected diseases. Chemical Biology & Drug Design, 90, 1067-1078.
Pantaleao, S.Q., Fujii, D.G.V., Maltarollo, V.G., da C. Silva, D., Trossini, G.H.G., Weber, K.C., et al. (2017). The Role of QSAR and Virtual Screening Studies in Type 2 Diabetes Drug Discovery. Medicinal Chemistry, 13, 706-720.
Vital, D., Arribas, M., Trossini, G. (2014). Molecular Modeling and Docking Application to Evaluate Cruzain Inhibitory Activity by Chalcones and Hydrazides. Letters in Drug Design and Discovery, 11, 249-255.
Blau, L., Menegon, R.F., Trossini, G.H.G., Molino, J.V.D., Vital, D.G., Cicarelli, R.M.B., et al. (2013). Design, synthesis and biological evaluation of new aryl thiosemicarbazone as antichagasic candidates. European Journal of Medicinal Chemistry, 67, 142-151.
You can view some of Dr Drielli’s work below and links to her professional profile.
Orcid: https://orcid.org/0000-0001-9270-0466
Research Gate: https://www.researchgate.net/profile/Drielli-Gomes-Vital-Fujii
Scopus: https://www.scopus.com/authid/detail.uri?authorId=55829534000
Google Scholar: https://scholar.google.com/citations?user=F9U50AEAAAAJ&hl=pt-BR
Linkedin: linkedin.com/in/driellivital
Escavador: https://www.escavador.com/sobre/6101380/drielli-gomes-vital
CDIPD: https://cdipd.org/index.php/about-us/visiting-scientists
Can you take Trazodone and Melatonin together?
You can take Trazodone and Melatonin together, but only if recommended by your healthcare provider. Trazodone and Melatonin may cause some additive side effects, especially sedation, as they can cause drowsiness. (1,2)
Trazodone is an antidepressant which is used to treat a variety of mental health-related problems (1). Melatonin, on the other hand, is a hormonal supplement to treat a number of sleep-related issues (2).
Although Trazodone and Melatonin don’t chemically interact with each other, they can affect your mental alertness.
If your doctor thinks Melatonin is a good treatment for your sleep disturbances while you’re being treated with trazodone, he/she will most likely adjust the doses and advise you to take the two meds at separate times.
This way you will avoid the presence of both Trazodone and Melatonin in your body simultaneously. Generally, Melatonin should be cautiously used in patients who are already taking a prescription sleep aid, including antidepressants and benzodiazepines like Lorazepam.
Potentail benefits of taking Trazodone and Melatonin together
When taken together, Trazodone and Melatonin may have potential benefits in aiding sleep and improving sleep quality. Trazodone can help with falling asleep and staying asleep throughout the night (1).
On the other hand, Melatonin as a supplement can further support the body’s natural sleep rhythms, promoting a sense of drowsiness and making it easier to fall asleep (2).
The combination of Trazodone and Melatonin may have a synergistic effect, enhancing their sleep-promoting properties. By working together, they can potentially improve overall sleep duration and reduce instances of nighttime awakenings (1,2).
It’s important to note that combining medications should only be done under the guidance and approval of a healthcare professional.
Potentail risks of taking Trazodone and Melatonin together
While there may be potential benefits to taking Trazodone and Melatonin together, there are also some potential risks that need to be considered. One of the main concerns is the increased risk of drowsiness and sedation (1,2).
Both Trazodone and Melatonin can cause drowsiness on their own, and when taken together, their effects can add up, leading to excessive sleepiness during the day and impairing your ability to perform daily activities. This is especially important if you need to drive or operate heavy machinery (1,2).
Additionally, combining these medications may increase the risk of certain side effects such as dizziness, confusion, and difficulty concentrating.
It’s also essential to be cautious about potential interactions with other medications you may be taking, as Trazodone and Melatonin can interact with certain drugs, potentially leading to adverse effects.
Final words
To sum up, taking Trazodone and Melatonin together can have some potential benefits and risks. It depends on your specific condition whether or not your body needs Melatonin while being treated with a sedative antidepressant.
It’s crucial to consult with a healthcare professional before taking Trazodone and Melatonin together. They can evaluate your specific health situation, consider any other medications you are taking, and determine if the combination is safe and appropriate for you.
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References
1.-
Shin JJ, Saadabadi A. Trazodone. 2022 Jul 10. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 Jan–. PMID: 29262060. https://www.ncbi.nlm.nih.gov/books/NBK470560
2.-
Pévet P. Melatonin. Dialogues Clin Neurosci. 2002 Mar;4(1):57-72. doi: 10.31887/DCNS.2002.4.1/ppevet. PMID: 22034091; PMCID: PMC3181670. https://pubmed.ncbi.nlm.nih.gov/22034091/
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