Does Trazodone affect blood sugar levels? 

In this brief article, we will discuss whether Trazodone may affect blood sugar levels and explore what to do if you experience fluctuations in your blood sugar levels during treatment with Trazodone. We will also examine research studies on this subject and will briefly mention the possibility of withdrawal symptoms and side effects associated with Trazodone.

Trazodone should not significantly affect your blood sugar levels. 

Although psychotropic medications are known for the potential to cause metabolic dysregulation, there is no evidence in the literature indicating that Trazodone directly affects blood sugar levels with clinically significant results (1,2,3).

However, remember that each person is unique and responds differently to treatments. Talk to your doctor if you notice fluctuations in your blood sugar levels during treatment with Trazodone.

It is important to know that Trazodone can cause withdrawal symptoms and side effects (1,4).

If you experience any unusual or concerning issues while taking this medication, it is advisable to contact your doctor.

Does Trazodone affect blood sugar levels? 

Trazodone should not significantly affect your blood sugar levels.  

This type of effect is not reported as either a rare adverse reaction of Trazodone.

Studies directly assessing the effect of this medication on blood sugar levels are scarce in the literature, but the few available ones have not shown any significant difference regarding this specific outcome (1,2).

However, it is not possible to predict with certainty how your body will react to taking Trazodone, as each person is unique and responds differently to treatments.

Additionally, it is important to note that Trazodone is associated with other adverse effects, some of which can be serious (1). Seek medical attention if you experience any abnormal symptoms while taking this medication. 

What to do if you suspect that Trazodone is affecting your blood sugar levels? 

If you notice fluctuations in your blood sugar levels during treatment with Trazodone, talk to your healthcare provider. 

They will likely investigate the cause of your issue, and if it is indeed associated with the use of the medication, they may consider adjusting the treatment or replacing Trazodone with another more suitable medication. 

You should not stop using the medication without consulting your doctor first.

What does research studies say about the effects of Trazodone on blood sugar levels?

There is limited evidence  about the effects of Trazodone on blood sugar levels specifically. 

In general, the literature suggests that the use of psychotropic medications can cause hyperglycemia, type 2 diabetes mellitus, and other metabolic disorders, but there is no evidence indicating that Trazodone directly affects blood sugar levels (3). . 

Only one study was found in the literature that evaluated the effects of a few antidepressants, including Trazodone, on blood sugar levels. The aforementioned study concluded that treatment with Trazodone did not significantly affect HbA1c levels – a measure of blood glucose control (2).. 

This indicates that the effects of Trazodone on blood sugar levels are not clinically significant and this antidepressant can be used in people with diabetes. 

However, remember that an individual’s response to the medication can make a difference. 

Do not hesitate to speak with your doctor if you notice fluctuations in your blood sugar levels during treatment with Trazodone. They may consider adjusting the treatment or replacing Trazodone with another more suitable medication. 

Can Trazodone cause withdrawal symptoms?

Withdrawal symptoms are common among individuals who abruptly stop using Trazodone. The symptoms may include (4):

• Dizziness
• Nausea
• Headache
• Confusion
• Anxiety
• Agitation
• Difficulty falling asleep or staying asleep
• Extreme tiredness
• Seizures
• Pain, burning, or tingling in the hands or feet
• Frenzied or abnormally excited mood
• Ringing in the ears
• Sweating

If Trazodone needs to be discontinued, your doctor will suggest an appropriate taper schedule for you to ensure a safe withdrawal. 

Tell your doctor if you experience any of these symptoms when your dose of Trazodone is decreased.

What side effects are associated with Trazodone treatment?

The most common side effects of Trazodone include (1,4):

• Weakness or tiredness
• Dry mouth
• Dizziness or lightheadedness
• Headache
• Acid reflux
• Nausea or vomiting
• Diarrhea or constipation
• Blurred vision
• Nightmares
• Sexual side effects
• Tired, red, or itchy eyes
• Weight gain
• Increased appetite

Trazodone can also result in uncommon but more serious side effects. These may encompass:

• Serotonin syndrome: a potentially life-threatening condition that can occur when there is too much serotonin in the brain. Symptoms include confusion, agitation, fever, sweating, tremors, and muscle rigidity.
• Orthostatic hypotension: a sudden drop in blood pressure when you stand up or move your position.
• Priapism: a prolonged and painful erection that can occur in men.

There are other potential serious side effects associated with Trazodone. If you experience any unusual or concerning issues while taking this medication, it is advisable to contact your doctor. 

Conclusion

In this brief article, we discussed whether Trazodone may affect blood sugar levels and explored what to do if you experience fluctuations in your blood sugar levels during treatment with Trazodone. We also examined research studies on this subject and briefly mentioned the possibility of withdrawal symptoms and side effects associated with Trazodone.

References