Does Pristiq treat PTSD? (3+ findings)

In this article, we will discuss whether or not Pristiq treats PTSD (post-traumatic stress disorder), research studies on the effectiveness of Pristiq in treating PTSD, potential side effects of Pristiq, and the approved therapies for treating PTSD.

Does Pristiq treat PTSD?

Yes, Pristiq can help in treating PTSD (post-traumatic stress disorder). Although Pristiq is not FDA-approved for treating PTSD, some healthcare providers may prescribe Pristiq as an off-label medication for treating PTSD based on their professional opinion.

Pristiq is the brand name of the antidepressant medication desvenlafaxine. It belongs to the class of drugs known as SNRIs (Serotonin and Norepinephrine Reuptake Inhibitors). Pristiq functions by increasing serotonin and norepinephrine levels in the brain. (1)

Pristiq was shown effective in treating PTSD by modulating certain brain chemicals that are involved in the symptoms of PTSD such as anxiety, depression, and flashbacks symptoms. (2)

It’s crucial to remember that Pristiq is not a cure for PTSD and your healthcare provider might recommend using Pristiq in conjunction with other medications in order to get long-term relief.

What does research suggest?

Research studies have shown that SNRIs, such as venlafaxine and desvenlafaxine (Pristiq), have been effective in reducing the frequency and intensity of PTSD symptoms.

These symptoms include flashbacks, nightmares, and avoidance behaviors. The response rate to SNRIs was 78%, with a remission rate of 40% in patients with PTSD.

It is important to note that SNRIs are not FDA-approved for treating PTSD, but they can sometimes be used as off-label medications to alleviate symptoms in certain individuals. (3)

However, more research is needed to fully understand Pristiq’s viability as a treatment option for PTSD.

What are the potential side effects of Pristiq?

There are several side effects of Pristiq, some of which include: (4)

Common side effects

• Constipation.
• Drowsiness.
• Headaches and dizziness.
• Night sweats.
• Xerostomia (dry mouth).
• Insomnia (inability to sleep).
• Nausea.
• Loss of appetite.

Serious side effects

• SOB (Shortness of Breath) and tachycardia (fast heart rate).
• Bleeding from any part of your body such as blood in the cough, blood in the urine or feces, bleeding gums, or changes in the menstrual cycle.
• Blurred vision or any vision changes.
• Frequent muscle spasms.
• Seizures.
• Long-lasting confusion.
• Excessive euphoria or happiness and restlessness (inability to sit or stand still).

Seek medical attention immediately if you experience any of these adverse effects.

What are the dosage recommendations for using Pristiq to treat PTSD?

The recommended starting dose of Pristiq for treating PTSD is 50 mg per day, which is also the therapeutic dose. Pristiq can be taken at any time of the day and can be taken with or without food. However, it is important to take Pristiq at the same time every day to get the best results.

In case of need, the dose can be increased up to 400 mg per day, although it’s not recommended as higher doses have not shown to be more effective than the initial 50 mg dose. (5)

It’s important to keep in mind that people’s responses to medication may differ, so it’s crucial to follow your healthcare provider’s instructions to find the right dose for you.

Important tips to ensure the safe use of Pristiq for PTSD

There are several important tips to ensure the safe use of Pristiq for PTSD such as: (5)

• Pristiq can cause side effects such as nausea, headaches, sweating, and dizziness, especially at the beginning of treatment, if these side effects persist for longer than 4 weeks, consult your healthcare provider about reducing your dose or switching to an alternative with fewer adverse events.

• It’s crucial to inform your healthcare about any medications that you take to reduce the possible drug interactions and adverse effects.

• Inform your healthcare provider if you have an underlying medical condition such as liver, kidney, or heart disease. Your healthcare provider might adjust your dose based on your condition to avoid the accumulation of Pristiq in your body.

• Pristiq may increase the risk of suicidal thoughts, especially in younger adults. It’s crucial to seek medical attention immediately if you experience suicidal thoughts while taking Pristiq.

• It’s important to note that Pristiq is not approved for use in children and adolescents under the age of eighteen years.

• It is important to take your dose exactly as prescribed by your healthcare provider. Do not reduce or discontinue your dose suddenly without consulting your healthcare provider to avoid the withdrawal symptoms.

What are the approved therapies for treating PTSD?

There are certain approved therapies for managing and treating PTSD. Examples include: (6)

Psychotherapy

It is also known as talk therapy. Psychotherapy helps in reducing the symptoms of PTSD in many individuals. there are several types of psychotherapy, some of which include:

• CBT (Cognitive Behavioral Therapy) focuses on identifying and challenging negative thought patterns and beliefs related to the traumatic event.
• EMDR (Eye Movement Desensitization and Reprocessing) uses eye movements or other rhythmic stimulation to help you reprocess the traumatic memories.
• Exposure therapy can help you face your fears and triggers in a safe and controlled environment.

Medications

There are certain medications that can be used for treating PTSD such as:

• SSRIs like Paxil (paroxetine) and Zoloft (sertraline). These antidepressants are approved by the FDA for managing PTSD symptoms.
• Anxiolytics can also be used for treating PTSD symptoms. However, they can only be used for the short term due to the potential adverse effects of their use.
• Prazosin. It is a medication used for treating hypertension and was found effective in treating PTSD in certain individuals.

Based on my knowledge and research, Pristiq can help in treating PTSD. In my opinion, every person differs in their response to medications.

If you want to use Pristiq for treating PTSD, consult your healthcare provider. They will properly assess your condition and weigh the benefits and risks of using Pristiq in treating your PTSD. 

I recommend that you follow your healthcare provider’s guidelines, use the recommended dose for treating your PTSD, and follow the tips and precautions to ensure the safe use of Pristiq for treating PTSD.

References