Does Pristiq slow down metabolism? (+3 factors)

In this article, we will discuss whether or not Pristiq slows down metabolism, clinical studies and research findings on Pristiq’s impact on metabolic rate, factors influencing metabolic rates while taking Pristiq, and what you should do if Pristiq slows down your metabolism.

Does Pristiq slow down metabolism?

Pristiq may or may not slow down metabolism. Although Pristiq has been linked to some weight fluctuations, it is unclear how much it impacts metabolism. 

Pristiq is the brand name of the antidepressant medication desvenlafaxine which belongs to the class of drugs known as SNRIs (Serotonin and Norepinephrine Reuptake Inhibitors). Pristiq functions by increasing the concentrations of these natural neurotransmitters in the brain. (1)

The exact mechanism of action of Pristiq in affecting metabolic rate is not fully understood. However, Pristiq may have an effect on metabolic rate because norepinephrine is known to be involved in energy expenditure and metabolism. 

Furthermore, Pristiq may have an impact on the hypothalamus, a part of the brain that controls satiety, hunger, and appetite. (2)

What does research suggest?

Mixed research data exists regarding Pristiq’s effect on metabolism.

A research study was carried out to assess the metabolic rate of desvenlafaxine (Pristiq). Participants in the study were adult outpatients with a diagnosis of MDD (Major Depressive Disorder).

The group was treated with desvenlafaxine for 8 weeks (short-term), and those who responded to 12 weeks of open-label treatment were randomly assigned to receive either desvenlafaxine or a placebo for 6 months (long-term).

The mean weight reductions linked to desvenlafaxine were statistically significant despite being minor in both the short- and long-term investigations.

The study found that neither short-term nor long-term desvenlafaxine medication was linked to a clinically significant change in weight. (3)

On the other hand, additional research revealed that Pristiq may cause weight gain in certain individuals. However, when compared to the placebo, this weight gain is negligible and not statistically significant. (4)

What factors may slow down your metabolism while taking Pristiq?

There are several factors that can slow down your metabolism while taking Pristiq such as: (5), (6)

Medication dose: High Pristiq doses can affect metabolic rate while taking Prisriq. This can lead to decreasing the metabolism of Pristiq and prolonging its stay in your system.

Age: The elderly population is more prone to experience slowed metabolism when taking Pristiq than the younger population.

Underlying medical conditions: Certain medical conditions such as diabetes, hypothyroidism, and liver diseases can slow down metabolism while taking Pristiq.

Concomitant medications: Certain medications such as corticosteroids, beta-receptor antagonists, and HIV medications can slow down metabolism and cause weight gain while taking Pristiq.

Lifestyle factors: Physical inactivity, poor diet, and decreased sleep quality can slow down metabolism while taking Pristiq.

Genetics: Individuals with a genetic variant in the CYP2D6 enzyme may metabolize pristiq and other medications more slowly.

What should you do if Pristiq slows down your metabolism?

If Pristiq slows down your metabolism, consult your healthcare provider about reducing your medication dose. Your healthcare provider might gradually reduce your Pristiq dose over a period of weeks or months.

According to your condition, your healthcare provider might reduce your dose by 10-20% per week. You should take the reduced dose for at least one week before reducing the dose again.

Your healthcare provider will properly assess your situation and determine whether the slowed metabolism is caused by Pristiq or by other underlying medical conditions like hypothyroidism or concurrent medications. They will then take the best course of action accordingly.

If Pristiq is the cause of your slowed metabolism and persistently causes undesirable side effects such as weight gain. Your healthcare provider might switch you to an alternative with fewer adverse effects.

What are Pristiq alternatives if it slows down your metabolism?

There is a certain antidepressant alternative to Pristiq that can boost your metabolism which is:

Wellbutrin: It is the brand name of the medication bupropion that belongs to the class of drugs known as NDRI (Norepinephrine and Dopamine Reuptake Inhibitors).

Wellbutrin was proven to be the least antidepressant to cause weight gain as compared to other antidepressants such as Paxil, Cymbalta, and Effexor. (7)

Tips for boosting your metabolism

There are several tips that can help boost your metabolism. Examples include: (8)

• Green tea: Drinking green tea can boost your metabolism as it contains a compound called catechin which was found to help increase your metabolism.
• Get enough sleep: Lack of sleep can slow down your metabolism. It is recommended to sleep for 7-8 hours per night.
• Nutritious diet: It is also recommended to monitor your diet by eating a balanced diet that consists of vegetables, fruits, protein-rich foods, and whole grains in order to support a healthy metabolism.
• Exercise: Exercising regularly can help boost your metabolism and burn your calories.
• Hydration: Drinking plenty of water (8-10 glasses per day) can help your body burn calories more efficiently.

Based on my knowledge and research, Pristiq may or may not slow down your metabolism. If you experience weight gain or other metabolic problems while taking Pristiq, consult your healthcare provider about reducing your medication dose or switching to an alternative with fewer adverse effects.

References