Does Phenergan help with diarrhoea? 

Does Phenergan help with diarrhoea? 

No, Phenergan (Promethazine) does not help with diarrhoea. Phenergen is a member of the phenothiazines pharmacological class. It is mainly prescribed to treat allergy symptoms like itchiness, runny nose, sneezing, and watery eyes. 

Moreover, it can be used in the management of motion sickness and postoperative nausea and vomiting. Phenergan decreases allergy symptoms and prevents nausea and vomiting by inhibiting histamine receptors in the body (1).

It is an entirely different medication than meds primarily used in diarrhoea, and it does not control increased intestinal motility to control diarrhoeal stools. 

However, it can help you with nausea and vomiting associated with diarrhoea – as this medication is used for motion sickness and for vomiting caused by other conditions. As far as other symptoms of diarrhoea are concerned, Phenergan does nothing to control them. 

Make sure you take the right medication for diarrhoea, especially if it’s severe. It’s best to talk to your doctor or pharmacist before using any medication that you don’t know much about. Medications used for motion sickness or acid reflux like Pepcid, Zantac, etc do not help with diarrhoea.

So, make sure you are taking the right medication to help manage your diarrhoea symptoms.

What medications are used to treat diarrhoea? 

There are plenty of medications used, mostly OTC, for the management and treatment of diarrhoea symptoms. The most commonly used antidiarrheal medication is Imodium (Loperamide) which controls intestinal motility and helps reduce bathroom visits (2). 

Other OTC meds, like Pepto-Bismol (Bismuth subsalicylate) can also be used to manage diarrhoeal symptoms. Other important add-ons include Probiotics and electrolyte replenishers. 

However, diarrhoea can also be infectious and it usually requires proper antibiotic treatment to go away. Make sure you reach out to your healthcare provider if your diarrhoea is paired with chills and fever. 

Final words

Phenergan is not the right choice of medication for the management and treatment of symptoms associated with diarrhoea. It is used for allergic symptoms. Since it is a prescription medication, you shouldn’t take it even for allergies without talking to your doctor first. 

There are plenty of OTC meds for allergies as well as diarrhoea and your local pharmacist can guide you and recommend a suitable medication if your diarrhoeal symptoms are mild. 

However, you need to consult your doctor if your diarrhoea is severe and you have a fever as well. Such diarrhoea often requires appropriate antibiotic treatment.


  1. PubChem [Internet]. Bethesda (MD): National Library of Medicine (US), National Center for Biotechnology Information; 2004-. PubChem Compound Summary for CID 4927, Promethazine; [cited 2023 Feb. 15]. Available from:  
  2. National Health Services. Loperamide. [Internet]. [cited 2023 Feb. 15]. Available from: 

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