Does Paxil make you sweat? (5+ tips)

This article will discuss Paxil’s impact on sweating and explore the possible causes of Paxil-induced sweating. Additionally, the article will review relevant research findings, factors that influence Paxil-induced sweating, and potential management strategies for this side effect.

Does Paxil make you sweat?

Yes, Paxil (paroxetine) can cause sweating as a side effect. The exact mechanism by which Paxil may cause sweating is not fully understood. However, it is believed to be related to its effect on serotonin levels.

Paxil increases the availability of serotonin in the brain. This may affect the hypothalamus, which is responsible for regulating body temperature, and lead to excessive sweating or hyperhidrosis.

Not everyone who takes Paxil will experience sweating as a side effect, and the severity and frequency of sweating can vary among individuals. If you are experiencing bothersome sweating while taking Paxil, you should consult with your doctor for further evaluation and potential management options.

What does research suggest?

One study explored a case in which a patient experienced excessive sweating primarily on her head and back of the neck after taking paroxetine for at least 7 months. Symptoms gradually improved and resolved 5 weeks after discontinuation of paroxetine, suggesting a probable causal relationship [1].

In another study, researchers investigated the association between night sweats and commonly prescribed medications. They found that SSRIs, including paroxetine, were associated with night sweats. Additionally, thyroid hormone supplements and angiotensin receptor blockers can increase the risk of experiencing Seroxat-induced night sweats [2].

On the other hand, a case study involving a man with excessive sweating was conducted. He was diagnosed with palmar-plantar hyperhidrosis and was prescribed paroxetine, which led to a marked reduction in sweating and socio-occupational improvement [3].

The beneficial effect of paroxetine in reducing sweating in this case was believed to be due to its anticholinergic action or its antianxiety effects through central mechanisms. Overall, this suggests that paroxetine may decrease excessive sweating in certain conditions like palmar-plantar hyperhidrosis [3].

Lastly, research states that paroxetine can also be used in the treatment of hot flashes and night sweats associated with menopause. This suggests a potential benefit of paroxetine in reducing sweating in certain conditions [4].

In conclusion, the research suggests that paroxetine and other SSRIs can increase sweating and cause night sweats. However, paroxetine may also have a beneficial effect in reducing sweating in some conditions. Further investigation is needed to fully understand the effects of paroxetine on sweating.

What influences Paxil-induced sweating?

Several factors may increase the likelihood of increased sweating while taking Paxil. Surely, high temperatures, intense exercise, and humidity can increase the likelihood of sweating. In such situations, Paxil may enhance the body’s response to these factors, resulting in more pronounced sweating.

Furthermore, other factors that can increase sweating while taking Paxil include:

Drug interactions

Paxil can interact with other medications leading to an increased risk of sweating. Examples of these medications include other antidepressants like tricyclic antidepressants and selective serotonin reuptake inhibitors (such as sertraline and fluoxetine), and certain migraine medications such as triptans (e.g., sumatriptan) [2,5].

It’s important to inform your healthcare provider about all the medications, including over-the-counter drugs and supplements, to assess potential interactions.

Dose and duration

Sweating as a side effect may be influenced by the dosage and treatment duration of Paxil. Administering high doses of Paxil, or jumping to high doses without applying dose escalation, can increase the likelihood of experiencing sweating.

The duration of Paxil treatment can also affect the occurrence of sweating, even though such side effects are usually more prominent during the initial weeks as the body adjusts to the medication. With time, the sweating side effect may decrease.

Individual sensitivity

Every individual has a unique response to Paxil, and some people may be more sensitive to its effects, including sweating as a side effect. Individual sensitivity can vary, and it’s important to discuss any concerns with your doctor.

Moreover, the body’s metabolism plays a role in the occurrence of side effects like increased sweating. Genetic variations, enzyme deficiencies, liver function, and medical conditions can influence metabolism, potentially causing drug concentration changes and increased sweating.

Underlying Medical Conditions

Certain underlying medical conditions that can cause sweating include overactive thyroid, menopause, certain infections (e.g., tuberculosis), or uncontrolled diabetes. If any disease that is associated with increased sweating is present, it can contribute to excessive sweating when taking Paxil [6, 7]

How to manage Paxil-induced sweating?

The first step in managing increased sweating is to consider adjusting the dosage of Paxil. Surely, you must consult with your doctor before changing anything in your dosing regimen, they will evaluate your case and determine if a dose adjustment is necessary.

As for the recommended dosing regimen for Paxil, the initial dose is 20 mg per day. If you need to take a high dose, the dosage must be increased gradually, up to a maximum of 50 mg per day [8].

Other tips that can help manage Paxil-induced sweating include:

  • Wear loose-fitting clothing made of breathable fabrics.
  • Avoid triggers that may induce sweating, such as spicy foods or hot beverages.
  • Maintain a cool environment by using fans or air conditioning.
  • Apply over-the-counter antiperspirants containing aluminum chloride to areas prone to excessive sweating, as they can temporarily block sweat ducts and reduce sweat production. If these OTC options don’t work, your doctor may prescribe prescription-strength antiperspirants containing aluminum chloride hexahydrate.
  • Botox injections may be used in severe cases of localized excessive sweating (hyperhidrosis). They temporarily block nerve signals responsible for sweat production in specific areas like underarms or palms.
  • Anticholinergic drugs (e.g., glycopyrrolate) may be prescribed In rare cases where other management strategies are ineffective [9].

According to my knowledge, Paxil can indeed cause sweating as a side effect, likely due to its impact on serotonin levels. While not everyone will experience this side effect, it can vary in severity and frequency among individuals.

Based on my research, I concluded that some studies suggest a possible link between Paxil and increased sweating, particularly night sweats. However, I also found that Paxil may have a beneficial effect in reducing sweating in certain conditions like palmar-plantar hyperhidrosis.

Factors such as drug interactions, dosage and duration, individual sensitivity, body metabolism, and external factors can influence Paxil-induced sweating.

In my perspective, this side effect can be managed by adjusting the dosage, wearing breathable clothing, using antiperspirants, and exploring alternative treatments like Botox injections or anticholinergic drugs.

I additionally believe that It is important to consult with a healthcare provider for personalized advice and guidance.

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Mold JW, Holtzclaw BJ. Selective Serotonin Reuptake Inhibitors and Night Sweats in a Primary Care Population. Drugs Real World Outcomes. 2015 Mar;2(1):29-33. doi: 10.1007/s40801-015-0007-8. PMID: 27747615; PMCID: PMC4883206.,patients%20seen%20in%20primary%20care.


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Kim WO, Kil HK, Yoon KB, Yoon DM. Topical glycopyrrolate for patients with facial hyperhidrosis. Br J Dermatol. 2008 May;158(5):1094-7. doi: 10.1111/j.1365-2133.2008.08476.x. Epub 2008 Feb 22. PMID: 18294315.,secondary%20gustatory%20hyperhidrosis%20following%20sympathectomy.

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