Does Luvox-induced nausea go away? (+3 tips)

In this article, we are going to discuss whether or not Luvox-induced nausea fades away, how Luvox induces nausea, research results linking Luvox to nausea, what to do if Luvox-induced nausea persists, and tips for coping with Luvox-induced nausea.

Does Luvox-induced nausea go away?

Yes, Luvox-induced nausea does go away with time for most individuals. Nausea is one of the most common side effects of Luvox. Luvox is the brand name of the medication fluvoxamine, an antidepressant belonging to the class of drugs known as the SSRIs (Selective Serotonin Reuptake Inhibitors). (1)

The nausea side effect appears a few days after starting Luvox and goes away a few weeks later. Studies have shown that 29% of patients taking fluvoxamine (Luvox) experienced nausea as a side effect. (2)

Consult your healthcare provider if the nausea worsens or lasts longer than expected. They might be able to change your medication or suggest other helpful alternatives.

How does Luvox induce nausea?

The mechanism of action of Luvox in affecting the serotonin levels in the brain and body is hypothesized to be the cause of nausea. Elevations in serotonin levels can alter the digestive tract, resulting in nausea and other GI (Gastrointestinal) problems. (3)

Furthermore, Lucox occasionally results in appetite changes which can exacerbate nausea. While taking Luvox, certain patients may experience other GI problems such as diarrhea, constipation, or stomach pain.

It’s crucial to remember that not everyone who takes Luvox experiences nausea; in fact, this is frequently a transient side effect that gets better with time.

What does research suggest?

A study was carried out to assess the features of fluvoxamine-induced nausea (Luvox). This study examined the relationship between fluvoxamine and nausea from a number of angles. 

The percentage of patients who had nausea from fluvoxamine was 29%. Regarding sex, age, the starting and maximum fluvoxamine doses, and fluvoxamine’s plasma concentrations, as well as the clinical reaction to fluvoxamine, no statistically significant differences were seen between the patients with and without nausea.

The incidence of nausea in patients who received fluvoxamine at a dose lower than 50mg per day experienced less nausea than patients who received a dose higher than 50mg per day.

The study came to the conclusion that fluvoxamine-induced nausea is linked to the activation of serotonergic neurons. (4)

What factors can induce nausea when taking Luvox?

There are several factors that can induce nausea while taking Luvox such as: (5), (6)

Medication dose and timing: High Luvox doses can induce nausea while taking the medication. Additionally, taking Luvox on an empty stomach may induce vomiting in certain individuals.

Genetics: Individuals with variations in the MAO-A gene (Mono-Amine-Oxidase A) may be more susceptible to nausea while taking Luvox.

Underlying medical conditions: Individuals with certain medical conditions such as gastrointestinal diseases like peptic ulcers, liver failure, bulimia nervosa, and appendicitis are more prone to experience nausea while taking Luvox.

Concurrent medications: Certain medications and therapies such as chemotherapy, opioids, and NSAIDs (Non-Steroidal Anti-Inflammatory Drugs) can induce nausea while taking Luvox. It’s crucial to inform your healthcare provider about any medications that you take to avoid possible drug interactions and side effects.

Lifestyle factors: Alcohol, tobacco, and lack of exercise can induce nausea while taking Luvox.

What should you do if Luvox-induced nausea persists?

If Luvox-induced nausea persists, consult your healthcare provider about reducing your medication dose or switching to an alternative with fewer gastrointestinal adverse effects such as:

Mirtazapine: An atypical antidepressant that was shown effective in treating depression with fewer gastrointestinal side effects. (7)

Other SSRIs: Citalopram, fluoxetine, duloxetine, or bupropion can be used instead of Luvox and may have fewer gastrointestinal side effects. (7)

What are some coping strategies for Luvox-induced nausea?

There are several coping strategies that can manage and reduce Luvox-induced nausea, some of which include: (8), (9)

  • Take Luvox with food, this can help reduce nausea.
  • Stay hydrated by drinking lots of water throughout the day, this can help avoid constipation and can relieve nauseous feelings.
  • Steer clear of alcohol, alcohol can exacerbate nausea while taking Luvox.
  • Inform your healthcare provider about any medications you are taking. Certain medications such as chemotherapy, opioids, and iron supplements can exacerbate nausea.
  • Consult your physician about boosting your Luvox dosage gradually. It is possible to reduce the chance of Luvox’s adverse effects and let your body adjust to the drug by starting Luvox with a low dose and then gradually increasing it.
  • Your healthcare provider might be able to recommend anti-nauseous medications such as meclizine or bismuth subsalicylate to help reduce Luvox-induced nausea. 


Based on my knowledge and research, Luvox-induced nausea goes away with time after a few weeks of starting the medication. However, if nausea persists for longer than 4 weeks, consult your healthcare provider about reducing your dose or switching to an alternative with fewer adverse effects.







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Yoshida K, Naito S, Takahashi H, Sato K, Ito K, Kamata M, et al. Monoamine Oxidase A Gene Polymorphism, 5-HT2A Receptor Gene Polymorphism and Incidence of Nausea Induced by Fluvoxamine. Neuropsychobiology. 2003;48(1):10–3. Available from:


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