Does Luvox-induced drowsiness go away? (+5 factors)

In this article, we will discuss the drowsiness associated with the use of Luvox and the factors that may influence the duration of Luvox-induced drowsiness. We will also explore the management tips for Luvox-induced drowsiness if it does not get better with time.

Does Luvox-induced drowsiness go away?

Yes, Luvox-induced drowsiness goes away with time. Drowsiness is the most common side effect of Luvox that occurs in the initial course of treatment, however, it may subside on its own in the absence of any external risk factor that could prolong the duration of Luvox-induced drowsiness.

Luvox (fluvoxamine) is an antidepressant medication that works by increasing the levels of serotonin in the brain. This helps in the management of symptoms associated with various mental disorders such as depression and anxiety. Some studies also suggest that Luvox may also affect the levels of dopamine in the brain (1).

Drowsiness with Luvox occurs initially because your body requires time to adapt to the medication’s effects. It is important not to discontinue Luvox due to the occurrence of drowsiness or any other side effects in the first few days of treatment (2).

What is the mechanism of Luvox-induced drowsiness? 

The Luvox-induced drowsiness may occur due to the increased levels of serotonin in the brain potentially influencing sleep-wake cycles and contributing to drowsiness. Additionally, Levox has sedative properties which may contribute to drowsiness, especially when the medication is first initiated or the dosage is increased (4).

However, individuals react differently to medications including Levox, and what causes drowsiness in one person may not have the same effect in another. 

What factors can influence the duration of Luvox-induced drowsiness?

Generally, Luvox-induced drowsiness improves as the patient adjusts to the medication. However, patient’s responses to Luvox or any medication can vary among individuals. Several factors may influence the duration of Luvox-induced drowsiness, including:

  • high dosage
  • age and genetics
  • use of alcohol
  • concurrent use of drowsiness-causing medications
  • underlying health conditions

A high dose of Luvox causes severe drowsiness that may persist for a longer period of time. Healthcare professionals usually start Luvox at a minimum effective dosage to avoid unwanted side effects including drowsiness. 

The duration of drowsiness associated with Luvox also increases by concomitant use of medications that also cause drowsiness, such as sedatives and benzodiazepines. Excessive consumption of alcohol also increases the risk of persistent drowsiness while taking Luvox. 

 Moreover, individuals with pre-existing sleep disorders such as sleep apnea, narcolepsy, and periodic limb movement disorder may have a higher likelihood of experiencing drowsiness. 

Strategies to minimize and manage Luvox-induced drowsiness

Luvox-induced drowsiness is usually temporary and it subsides on its own. However, in the presence of risk factors, the duration of drowsiness caused by Luvox increases leading to persistent drowsiness that is effectively managed by following these tips:

Consult your healthcare provider

If you are experiencing persistent drowsiness with Luvox, it is important to discuss it with your healthcare provider. They can provide guidance on whether the side effects are likely to subside over time or if you need adjustments to the treatment plan.

Dosage adjustment

Your healthcare provider may adjust the dosage of Luvox or provide you with an alternative medication that is less likely to cause drowsiness, based on your individual needs. However, you should never discontinue Luvox without consulting your doctor, it may lead to withdrawal effects.

Pharmacological treatment

Your healthcare provider can also prescribe you an additional medication with Luvox, that is specifically designed to counteract drowsiness such as psychostimulants (3).

Change the timing of taking Luvox

Taking Luvox at night may be more suitable for some individuals. This allows the drowsiness to coincide with bedtime, potentially minimizing its impact on daily activities.


In conclusion, drowsiness caused by Luvox subsides over time. In my opinion, you should wait for a few days to allow your body to adjust to the medication, as the drowsiness may subside during this period. If the drowsiness persists or becomes concerning, it is recommended to consult with your healthcare provider for further guidance.

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Dell’Osso B, Allen A, Hollander E. Fluvoxamine: a selective serotonin re-uptake inhibitor for the treatment of obsessive-compulsive disorder. Expert Opin Pharmacother. 2005 Dec;6(15):2727-40. doi: 10.1517/14656566.6.15.2727. PMID: 16316311.


Silvestri, Rosalia & Pace-Schott, Edward & Gersh, Tamara & Stickgold, Robert & Salzman, Carl & Hobson, J.. (2001). Effects of Fluvoxamine and Paroxetine on Sleep Structure in Normal Subjects: A Home-Based Nightcap Evaluation During Drug Administration and Withdrawal. The Journal of clinical psychiatry. 62. 642-52. 10.4088/JCP.v62n0812.


Kelly K, Posternak M, Alpert JE. Toward achieving optimal response: understanding and managing antidepressant side effects. Dialogues Clin Neurosci. 2008;10(4):409-18. doi: 10.31887/DCNS.2008.10.4/kkelly. PMID: 19170398; PMCID: PMC3181894.


Wilson, S & Bell, C & Coupland, N & Nutt, David. (2000). Sleep changes during long-term treatment of depression with fluvoxamine – A home-based study. Psychopharmacology. 149. 360-5. 10.1007/s002139900362.

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