Does Luvox cause sweating? (+5 factors)

In this article, we will discuss the sweating caused by Luvox and the factors that increase the risk of Luvox-induced sweating. We will also discuss the management tips for Luvox-induced sweating.

Does Luvox cause sweating?

Yes, Luvox does cause sweating. It is listed as a common side effect of Luvox (fluvoxamine). However, it’s important to note that not everyone experiences this side effect, and its intensity and severity can vary among individuals.

Luvox (fluvoxamine) is a selective serotonin reuptake inhibitor antidepressant medication. It primarily works by increasing the levels of serotonin in the brain and to a lesser extent it also affects levels of dopamine. The increased levels of serotonin are responsible for the elevation of mood and the management of mental disorders including depression, anxiety, obsessive-compulsive disorder, and their associated symptoms (1).

What is the mechanism of Luvox-induced sweating?

The mechanism of Luvox-induced sweating involves the interference of fluvoxamine with serotonin reuptake. By inhibiting the reuptake of serotonin in the synaptic cleft, Luvox increases the extracellular levels of serotonin (4).

Serotonin plays an important role in thermoregulation through the modulation of extracellular serotonin levels. Luvox increases serotonin levels in the brain, influencing thermoregulatory processes and contributing to sweating as a side effect (4).

Increased levels of serotonin stimulate various serotonin receptors, particularly those involved in thermoregulation, leading to an imbalance in the autonomic nervous system. This imbalance may result in increased sweating as the body attempts to regulate its temperature (4).

What does research suggest?

According to research, sweating is a prevalent side effect associated with (Luvox) fluvoxamine (1).  A research study suggested that 9.2% of individuals reported experiencing excessive night sweating as a side effect of Luvox. This statistical evidence underscores the significance of recognizing and addressing the occurrence of sweating in individuals taking Luvox (2).

Research shows that Luvox may cause mild to moderate side effects, including sweating. However, these effects are usually manageable without changing the dose or stopping the medication. Understanding these details helps both individuals and healthcare providers work together for a better mental health treatment experience (3).

What factors can increase the risk of Luvox-induced sweating?

Certain factors may contribute to an increased risk of Luvox-induced sweating. Understanding these factors is crucial for individuals using this medication. These risk factors include:

Higher doses of Luvox may elevate the risk of side effects, including sweating. It is essential for individuals to be aware of their prescribed dosage and discuss any concerns with their healthcare provider.

Individual sensitivity: Responses to medications can vary among individuals. Factors such as metabolism and overall health may influence how the body reacts to Luvox, impacting the likelihood of experiencing sweating as a side effect.

 Underlying health condition: Certain health conditions may predispose individuals to increased sweating. Those with existing health concerns should communicate these to their healthcare provider for a comprehensive evaluation.

 Environmental factors, such as residing in hot and humid climates, can also contribute to sweating while taking Luvox. Individuals in such environments may need to manage their surroundings to alleviate discomfort.

Concurrent medications: Combining Luvox with other medications, particularly antidepressants, may potentially increase the risk of excessive sweating. Discussing all prescribed medications with a healthcare provider is crucial for minimizing risks.

What other medications can cause sweating?

Apart from Luvox, other medications may cause sweating as a potential side effect, such as (5):

  • other SSRIs (citaloram, escitaloram)
  • tricyclic antidepressants  (desipramine, amitriptyline)
  • opioids (fentanyl, morphine)
  • NSAIDs (ketorolac, naproxen)
  • antimicrobials (ciprofloxacin, ceftriaxone) 
  • antihypertensive (enalaprill, nefedipine) 

How to manage Luvox-induced sweating?

Managing Luvox-induced sweating involves a combination of lifestyle adjustments, medical interventions, and communication with your healthcare provider. Here are some general tips:

  • Consult your healthcare provider to discuss the possibility of adjusting the dosage, changing medications, or exploring alternative treatment options.


  • Identify and minimize exposure to triggers that can worsen sweating, such as hot and humid environments.


  •  Consider using over-the-counter or prescription-strength antiperspirants to help control sweating under the guidance of your healthcare provider.


  •  Practice stress-management techniques, such as deep breathing, meditation, or yoga, as stress can exacerbate sweating.

 In cases where the side effect of sweating persists with Luvox, your healthcare provider may recommend an alternative antidepressant medication. It is crucial, to emphasize that discontinuation of Luvox should never be done abruptly. Instead, carefully taper the dose of Luvox under the guidance of your healthcare provider to avoid potential distressing withdrawal symptoms.


In conclusion, based on my knowledge and research, sweating is a common side effect associated with the use of fluvoxamine. However, individual responses to medications may vary and some individuals may not experience sweating with fluvoxamine.

In the clinical setting, I have seen some patients reporting night sweats and sweating in general, after starting treatment with fluvoxamine and other SSRIs in general. It is advised to report excessive and persistent sweating caused by fluvoxamine to your healthcare provider so they may guide you based on your individual needs. 

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LiverTox: Clinical and Research Information on Drug-Induced Liver Injury [Internet]. Bethesda (MD): National Institute of Diabetes and Digestive and Kidney Diseases; 2012-. Fluvoxamine. [Updated 2021 May 11]. Available from:


Mold JW, Holtzclaw BJ. Selective Serotonin Reuptake Inhibitors and Night Sweats in a Primary Care Population. Drugs Real World Outcomes. 2015 Mar;2(1):29-33. doi: 10.1007/s40801-015-0007-8. PMID: 27747615; PMCID: PMC4883206.


Westenberg HG, Sandner C. Tolerability and safety of fluvoxamine and other antidepressants. Int J Clin Pract. 2006 Apr;60(4):482-91. doi: 10.1111/j.1368-5031.2006.00865.x. PMID: 16620364; PMCID: PMC1448696.


Maswood N, Cosmi S, Alfinito PD, Leventhal L, Deecher DC. The role of the selective serotonin reuptake inhibitor fluoxetine in temperature regulation in ovariectomized rat models. Neuroendocrinology. 2006;84(5):330-8. doi: 10.1159/000098322. Epub 2006 Dec 28. PMID: 17192701.


Cheshire WP, Fealey RD. Drug-induced hyperhidrosis and hypohidrosis: incidence, prevention and management. Drug Saf. 2008;31(2):109-26. doi: 10.2165/00002018-200831020-00002. PMID: 18217788.

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