Does Luvox cause hyponatremia? (+3 factors)

In this article, we will discuss whether or not Luvox causes hyponatremia, research studies on Luvox’s association with hyponatremia, managing hyponatremia while taking Luvox, and precautions to prevent hyponatremia caused by Luvox.

Does Luvox cause hyponatremia?

Yes, Luvox can cause hyponatremia. Nevertheless, Luvox causes hyponatremia as a result of a syndrome known as SIADH (Syndrome of Inappropriate Anti-Diuretic Hormone). Discontinuing Luvox can effectively reverse this effect. (1)

Luvox is the brand name of the medication fluvoxamine, it belongs to the class of drugs known as SSRIs (Selective Serotonin Reuptake Inhibitors). Luvox is indicated for the treatment of OCD (Obsessive Compulsive Disorder) and SAD (Social Anxiety Disorder). (2)

Hyponatremia is a condition that is characterized by low sodium levels (below 135 mEq/L). Sodium is an electrolyte that aids in controlling the volume of water within and surrounding your cells. (3)

How does Luvox cause hyponatremia?

Hyponatremia is believed to be caused by suppression and inhibition of norepinephrine reuptake and may possibly be connected to Luvox’s impact on the body’s water balance. (4)

Blood sodium levels may drop as a result of Luvox’s tendency to make the body retain water. Hyponatremia may be exacerbated in certain instances by Luvox’s potential to impair renal function. 

It has been reported that in the initial weeks to months following Luvox commencement, SSRI-induced hyponatremia might occur. (4)

What does research suggest?

According to research, three documented cases of patients receiving fluvoxamine reported having hyponatremia. In these cases, the most likely mechanism was SIADH (improper secretion of antidiuretic hormone). The hyponatremia was severe (103-112 mmol/L).

The study came to the conclusion that fluvoxamine can cause hyponatremia, particularly in the elderly. Several reports have indicated that when SSRIs were taken, patients aged 70 years and older were at risk of developing hyponatremia.

It is crucial to monitor electrolyte and water levels while using SSRIs for depression treatment. (5)

What are the possible consequences of hyponatremia?

If left untreated, hyponatremia can have a variety of negative consequences such as: (6)

  • Impaired mental function.
  • Cerebral edema.
  • Abnormal gait.
  • Fractures and osteoporosis.
  • Hyponatremia is associated with a higher risk of admission to the CCU (Critical Care unit).

Extreme Hyponatremia is linked to significant clinical and economic ramifications as well as a higher chance of death. Therefore, it is crucial to seek medical attention immediately if you experience hyponatremia while using Luvox.

What factors can contribute to hyponatremia while taking Luvox?

There are several factors that can contribute to hyponatremia while taking Luvox such as: (7)

Medication dose: High Luvox doses can induce hyponatremia.

Underlying medical conditions: Certain medical conditions such as diarrhea, vomiting, liver, heart, and kidney diseases can induce hyponatremia while taking Luvox.

Concomitant medications: Medications such as diuretics and NSAIDs (Non-Steroidal Anti-Inflammatory Drugs) can increase hyponatremia while taking Luvox.

Lifestyle factors: Excessive drinking of alcohol can exacerbate hyponatremia while using Luvox.

How to manage hyponatremia while taking Luvox?

The following techniques can be used to manage hyponatremia while taking Luvox: (8)

  • Consume electrolyte-containing liquids such as coconut water to help keep salt and sodium levels stable.
  • Steer clear of drinking too much water as this can aggravate hyponatremia by diluting the blood even more.
  • Consume high-sodium food like pickles, salted almonds, salted cheese, and olives.
  • Regularly check your sodium levels, and notify your physician right away if you experience any hyponatremia symptoms such as confusion, and headaches.
  • Your healthcare provider could suggest other therapies, including IV (Intravenous) fluids to raise your sodium levels and other medications to treat the symptoms of hyponatremia such as analgesics for headaches and anti-nausea medications.

If hyponatremia persists, consult your healthcare provider about reducing your medication dose or switching to an alternative with fewer hyponatremia symptoms such as: (9)

  • Mianserin. It is an atypical antidepressant that was proven to not cause hyponatremia as a side effect of its use.
  • Cymbalta (duloxetine).
  • Effexor (venlafaxine). 
  • Remeron (mirtazapine).

These medications were shown to be effective in treating depression and have been shown to be the least antidepressants linked to hyponatremia when compared to citalopram (Celexa) and other SSRI antidepressants.

Precautions to avoid Luvox-induced hyponatremia

There are some precautions you can take to help reduce Luvox-induced hyponatremia such as: (10)

  • Regularly monitor your blood sodium levels, particularly in the elderly or if you have an underlying medical condition that could exacerbate hyponatremia such as heart, liver, or kidney diseases.
  • Steer clear of excessive perspiration and heat-related exercise.
  • Inform your healthcare provider about any medications you are taking, as there are certain medications that can exacerbate hyponatremia such as diuretics, analgesics, and hypertensive medications.
  • Don’t overdrink water or fluids, sip on fluids gradually as drinking a lot of water can induce hyponatremia in some individuals.
  • Luvox shouldn’t be abruptly discontinued, if you want to discontinue your medication for any reason, consult your healthcare provider to avoid withdrawal symptoms.


Based on my knowledge and research, Luvox can cause hyponatremia. In my opinion, this side effect will fade away after the first few weeks of taking Luvox. However, if hyponatremia persists while taking Luvox, consult your healthcare provider about reducing your dose or switching to an alternative with fewer adverse events.





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Chiu CY, Sarwal A, Azhar Munir R, Widjaja M, Khalid A, Khanna R. Syndrome of Inappropriate Antidiuretic Hormone (SIADH) Induced by Long-Term Use of Citalopram and Short-Term Use of Naproxen. American Journal of Case Reports. 2020 Aug 14;21. Available from:,take%20%5B2%2C3%5D.


Inaguma D, Kitagawa W, Hayashi H, Kanoh T, Kurata K, Kumon S. [Three cases of severe hyponatremia under taking selective serotonin reuptake inhibitor (SSRI)]. Nihon Jinzo Gakkai Shi [Internet]. 2000 Oct 1 [cited 2023 Nov 14];42(8):644–8. Available from: 


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Leth-Møller KB, Hansen AH, Torstensson M, Andersen SE, Ødum L, Gislasson G, et al. Antidepressants and the risk of hyponatremia: a Danish register-based population study. BMJ Open [Internet]. 2016 May 18;6(5). Available from:


Mayo Clinic. Hyponatremia – Symptoms and causes [Internet]. Mayo Clinic. 2022. Available from: 

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