Does Luvox cause confusion? (+3 factors)

In this article, we will discuss whether or not Luvox causes confusion, How Luvox can cause confusion, research studies on Luvox’s impact on cognition and confusion, factors that contribute to confusion while taking Luvox, and what to do if Luvox causes persistent confusion.

Does Luvox cause confusion?

Yes, Luvox can cause confusion. Confusion is a potential and serious side effect of Luvox. Luvox is the brand name of the medication fluvoxamine, an antidepressant that belongs to the class of drugs known as the SSRIs (Selective Serotonin Reuptake Inhibitors). It is used mainly in treating OCD (Obsessive Compulsive Disorder) and SAD (Social Anxiety Disorder). (1)

Feeling disoriented, having trouble thinking, or having trouble remembering things are all signs of confusion. It is important to remember that this adverse effect is rare and usually disappears when the body becomes adjusted to the medication.

However, you should get in touch with your healthcare provider right away if confusion or disorientation symptoms don’t fade away or get worse. In addition, seek medical attention immediately if you experience any additional symptoms such as hallucinations, agitation, or suicidal thoughts while taking Luvox.

How can Luvox cause confusion?

Luvox’s mechanism of action in increasing serotonin levels in the brain can cause confusion. Luvox works by inhibiting the reuptake of serotonin in the brain, which in turn raises the amount of serotonin that is available to the brain’s neurons.

Serotonin is a natural neurotransmitter that controls mood, hunger, and sleep. Confusion and disorientation can result from variations in serotonin levels as they impact the brain’s ability to process information. For some individuals, this may be a more long-term adverse effect, while for others, it may just last momentarily while the body adjusts to the new serotonin levels. (2)

Higher doses of Luvox are associated with a higher risk of confusion, which may also be more prevalent in the elderly or patients with a history of cognitive problems.

What does research suggest?

Research has shown that SSRIs can have a number of cholinergic adverse effects, including confusion, disorientation, memory loss, and difficulty concentrating.

Comparing fluvoxamine (Luvox) against other SSRIs such as paroxetine, sertraline, fluoxetine, citalopram, and venlafaxine, it was found that fluvoxamine caused the least amount of cholinergic side effects including confusion, and difficulty concentrating. Citalopram as well as other SSRIs can also cause CNS-related side effects such as dissociation. (3)

However, a different study found that fluvoxamine could reverse CNS atrophy and improve cognitive function and performance.

The current analysis investigates fluvoxamine’s mechanism in influencing cognitive performance and the potential benefits of fluvoxamine for improving cognitive outcomes in depressed patients. (4)

What factors can cause confusion while taking Luvox?

There are several factors that can induce confusion while taking Luvox such as: (5)

Medication dose: Excessive Luvox dosages can induce confusion and other cognitive side effects.

Age: The elderly population is more prone to experience confusion than the younger population while taking Luvox.

Concomitant medications: Certain medications such as hallucinogens, antihistamines, sedatives, and opioids can cause sedation as a side effect of their usage. It’s crucial to inform your physician about the medications that you take while using Luvox.

Underlying medical conditions: Diseases such as liver, kidney, diabetes, and heart diseases may have an impact on the body’s ability to metabolize Luvox, which could induce confusion.

Pre-existing cognitive or brain diseases: You may be more prone to become confused while taking Luvox if you already have cognitive or brain diseases, such as dementia, Alzheimer’s disease, schizophrenia, stroke, brain cancer, and meningitis.

Lifestyle factors: Alcohol and dehydration can induce confusion while taking Luvox.

What should you do if your confusion persists while taking Luvox?

If your confusion and disorientation symptoms persist while taking Luvox, seek medical attention immediately. Your healthcare provider will properly assess your situation and determine whether Luvox is the cause of confusion or whether there are other contributing factors.

If Luvox is the cause of your confusion and disorientation symptoms. They might reduce your medication dose or switch you to alternatives with fewer cognitive adverse effects such as:

Agomelatine: Sold under the brand name Valdoxan, an atypical antidepressant that was shown effective in treating depression and doesn’t cause confusion as a side effect of its use. (6)

Mirtazapine: An atypical antidepressant that is sold under the brand name Remeron, was shown effective in treating depression and has been proven to enhance cognitive functions in certain individuals. (7)

Based on my knowledge and research, Confusion is one of the potential side effects of Luvox. In my opinion, this side effect fades away after a few weeks of using the medication.

However, if confusion persists for longer than four weeks, consult your healthcare provider about reducing your medication dose or switching to an alternative with fewer cognitive adverse effects.

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Robillard R, Carpenter JS, Feilds KL, Hermens DF, White D, Naismith SL, et al. Parallel Changes in Mood and Melatonin Rhythm Following an Adjunctive Multimodal Chronobiological Intervention With Agomelatine in People With Depression: A Proof of Concept Open Label Study. Frontiers in Psychiatry [Internet]. 2018 Dec 11;9:624. Available from:


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